BayBiosciences.com provides Osteoid Osteoma bone tumor tissue samples FFPE blocks with matching serum, plasma and peripheral blood mononuclear cells (PBMC) biofluid specimens from unique pediatric patients.

Osteoid Osteoma Overview

An osteoid osteoma is a benign (noncancerous) bone tumor that usually develops in the long bones of the body, such as the femur (thighbone) and tibia (shinbone). In fact, this tumor is most frequently found in the legs; however, it may occur also at other bones in nearly any part of the body.

The center of an osteoid osteoma is the nidus. Specifically, it consists of growing tumor cells, blood vessels, and cells that eventually form bone. Additionally, a bony shell surrounds the nidus.

Although osteoid osteomas can cause pain and discomfort, they do not spread throughout the body. Moreover, osteoid osteomas can affect people of all ages; nevertheless, they occur more frequently in children and young adults, while it is very rare in older adults over the age of 50.

To elaborate, an osteoid osteoma is a benign (non-cancerous), small tumor that usually grows in the long bones of a person’s lower extremities. Notably, the thighbone is the most common location, although it can occur in the bones of the hand, and it sometimes occurs in the lower part of the spine.

Typically, it usually emerges sometime during the teenage years or early adulthood. Interestingly, the condition seems to occur more often in boys than girls.

  • Firstly, the tumor may cause pain, but it doesn’t spread.
  • Secondly, in young children, it may deform the bone or stimulate the bone to grow larger or longer.
  • Thirdly, it usually appears in teenagers and young adults.
  • Moreover, it’s cause is unknown.
  • Furthermore, the most common treatment uses radio frequencies to heat and kill cancerous cells.
  • Lastly, treatments are usually successful, though the tumors can come back.

Signs and Symptoms of Osteoid Osteoma

Signs and symptoms of Osteoid Osteoma may vary from patient to patient, the most common symptoms include:

  • Dull or sharp pain that worsens at night
  • Joint pain and stiffness
  • Pain that is usually relieved by aspirin, ibuprofen or other anti-inflammatory drugs
  • Limping
  • Fever
  • Enlargement or deformity of a finger
  • Curvature of the spine (scoliosis)
  • Painful scoliosis and muscle spasticity, when the tumor is located in the spine
  • Growth disturbance, when the tumor is involved with a bone’s growth plate
  • Muscle wasting
  • Bowing deformity
  • Nerve symptoms like sciatica when the tumor is located in the spine
  • There may be a lot of inflammation around the tumor and the soft tissue around the tumor may be painful or swollen. Sometimes even a lump may be felt.

Causes of Osteoid Osteoma

An osteoid osteoma occurs when certain cells divide uncontrollably, forming a small mass of bone and other tissue. This growing tumor replaces healthy bone tissue with abnormal, hard bone tissue. No one knows exactly why this occurs. Researchers are still working to understand what causes osteoid osteomas to form.

They seem to start with inflammation in the bone. When that occurs, blood vessels in the area start to expand and grow. Bone-producing cells called osteoblasts soon start to multiply. They lay down the building blocks for bone. Cells that break down bone, called osteoclasts, also become part of the osteoma. The growing  tumor puts pressure on the surrounding bone. This hardens and forms a shell around the tumor.

Diagnosis of Osteoid Osteoma

Most patients with osteoid osteomas have pain for months or even years before the disease is diagnosed. In children, people may assume that the child’s pain is from growing pains. Unlike growing pains, physical activity has no effect on the pain of osteoid osteomas.

To find the cause of the pain, the doctor will ask about the nature and severity of the pain. He or she may also ask:

  • Whether certain things make the pain better or worse
  • How long the pain has been present
  • Whether you have ever been injured in that area of the body

X-rays can help you doctor diagnose the osteoid osteoma. On an X-ray, the bony shell appears white and the nidus will appear dark. Sometimes other imaging tests can help make sure that something else, such as an infection or cancer, is not causing the pain. These studies may include:

  • Blood tests
  • CT scans
  • MRI scans
  • Bone scans
  • Biopsy

Treatment of Osteoid Osteoma

Osteoid osteomas may shrink on their own. But that usually takes years. Some patients get paoin relief from nonsteroidal anti-inflammatory drugs (NSAIDs). Some NSAIDs, such as aspirin, ibuprofen, and naproxen, are available without a prescription. Others are only available by prescription. NSAIDs may speed up the shrinkage of osteoid osteomas. But they can cause problems such as stomach irritation, ulcers, bleeding, high blood pressure, rash, and ankle swelling. They can sometimes also cause kidney or heart problems.

Because osteoid osteomas can be quite painful and take a long time to go away, healthcare providers often treat them more aggressively. Treatment options include:

  • Surgery
  • CT-guided drill resection
  • Radiofrequency ablation

Biospecimens

biospecimens

Bay Biosciences is a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens, and human bio-fluid collections.

Human biospecimens are available including cancer (tumor) tissue, cancer serum, cancer plasma, cancer peripheral blood mononuclear cells (PBMC). and human tissue samples from most other therapeutic areas and diseases.

Bay Biosciences maintains and manages its own biorepository, the human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and from normal healthy donors for controls, available in all formats and types.

In fact, our biobank procures and stores fully consented, de-identified and institutional review boards (IRB) approved human tissue samples, human biofluids such as serum samples, plasma samples from various diseases and matched controls.

Also, all our human tissue collections, human biospecimens and human biofluids are provided with detailed, samples associated patient’s clinical data.

In fact, this critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers, and genetic information.

Additionally, researchers find the patient’s data associated with the human biospecimens extremely valuable and use it to help identify new effective treatments (drug discovery & development) in oncology, as well as in other therapeutic areas and diseases.

Bay Biosciences banks wide variety of human tissue samples and human biological samples, including fresh frozen human biospecimens cryogenically preserved at – 80°C.

For example fresh frozen tissue samples, tumor tissue samples, formalin-fixed paraffin-embedded (FFPE), tissue slides, with matching human bio-fluids, whole blood and blood-derived products such as human serum, human plasma and human PBMCs.

Bay Biosciences is a global leader in collecting and providing human tissue samples according to the specified requirements and customized, tailor-made collection protocols.

Please contact us anytime to discuss your special research projects and customized human tissue sample requirements.

Types of Biospecimens

Bay Biosciences provides human tissue samples (human specimens) and human biofluids from diseased and normal healthy donors which includes:

Moreover, we can also procure most human biospecimens and human biofluids, special collections and requests for human samples that are difficult to find. All our human tissue samples and human biofluids are procured through IRB-approved clinical protocols and procedures.

In addition to the standard processing protocols, Bay Biosciences can also provide human biofluids such as  human plasma, human serum, and human PBMCs bio-fluid samples using custom processing protocols; you buy donor-specific collections in higher volumes and specified sample aliquots from us.

Bay Biosciences also provides human biospecimens from normal healthy donors; volunteers, for controls and clinical research, Contact us Now.