Researchers find human serum (sera) samples to be a highly effective tool in medical research and clinical studies. Moreover, over the years, they have proven suitable for in-vitro and biochemical diagnostic applications.

Additionally, researchers also consider them an excellent choice for standards, controls, and calibrators. Furthermore, Bay Biosciences takes pride in offering consistent high-quality human blood serum for research **that ultimately** helps researchers produce innovations and breakthroughs.

What Is Blood Serum?

The component of blood that is not a blood cell or a clotting factor is, in fact, the serum. Moreover, all the endogenous and exogenous liquids that circulate in the blood are carried by it. Furthermore, essential substances that include fatty acids and fat-soluble hormones are also transported by it. For instance, an example is thyroid hormones, which are acted upon by most of the cells that are in the human body.

In addition, all of the blood proteins, such as albumin and other serum proteins that are not used for clotting by the body, are included in serum. Additionally, it also contains antibodies, hormones, antigens, electrolytes, and substances that are passed through the bloodstream.

How Is Blood Serum Used?

Scientists and pharmaceutical companies around the world use serum in a range of diagnostic and research applications.

Furthermore, access to high-quality human serum specimens drives innovations in genetics, drug discovery and creation, biomarker research, molecular diagnostics, and more.

In particular, researchers consider off-the-clot serum an ideal medium for metabolic research because it’s available in the original transfer packs. Additionally, they can use specialized serums such as human AB serum, which lacks antibodies against the antigens in type A and B blood. **Consequently**, researchers use this serum in tissue engineering and cell therapy applications.

Researchers use human complement serum, which contains activated serum proteins, in biocompatibility experiments. Furthermore, they can access a wide range of customized samples to fit specific projects and research needs.

How Human Serum Samples Are Collected?

The collection of human serum depends on the purpose of the serum. Specifically, when someone donates blood, healthcare professionals can separate the blood into different parts for a range of therapeutic and research purposes.

For instance, researchers can use white blood cells to aid the immune system. In addition, medical personnel can administer blood plasma, which contains powerful clotting factors, to patients suffering from problems such as liver failure or blood clotting disorders. Ultimately, the remaining substance after removing these other components is human serum.

Approved collection centers in our global network of partner hospitals collect human serum samples for research. Furthermore, our network of partner hospitalss on three continents assures a consistent supply of high-quality research materials. Additionally, patients or participants provide consent for all sample collections.

Researchers have choices between two processes:

True Human Serum

Also described as “off the clot,” this process begins by collecting whole blood. First, we allow the blood to clot naturally at room temperature, without using an anticoagulant. Next, a centrifuge separates the serum and removes it.

Subsequently, we then freeze the serum until needed. Moreover, we keep it in aseptic conditions at each stage of production to reduce the risk of bacterial contamination. Finally, each donor of true human serum yields about 20 mL of material.

Plasma-Derived Human Serum

Researchers can also derive human serum from fresh or frozen plasma treated with an anticoagulant. The process involves dialysis to remove the anticoagulant from the plasma. They then restore the protein levels to normal. This type of recovered human serum serves as a useful matrix for positive controls. They can also strip it of other components for testing, such as insulin or thyroid hormones.

Bay Biosciences collects human serum for research and ships it frozen. We add no preservatives unless the customer specifically desires and requests them.

As a leading biobank, maintains an independent quality control department that oversees every aspect of Quality Assurance and compliance.

Our high-quality clinical grade samples come from unique individual donors. (We also provide pool samples upon request if those fit your specific research needs.)

In addition to providing normal healthy donor blood serum, we also offer disease state serum and plasma for research.

We provide samples with complete clinical histories. If desired, we can also include targeted therapy information or materials from specific cohorts, such as first-time mothers.

Safety and Ethics

Bay Biosciences uses only characterized, consented, and documented human specimens. Customers can rest assured that we handle all samples and clinical data in a way that complies with the highest regulatory and ethical standards.

As an industry leader, we are passionate about staying appraised of and complying with every applicable law and regulation. Our in-house legal team and an external IRB oversee all domestic collections.

For the safety of everyone who will work with our human serum samples, every sample lot is tested and found negative for:

  • HIV
  • Hep C
  • Hep B
  • Syphilis

Have questions about human serum samples? contact us we can discuss the specific research needs of your study sponsor to identify the human serum product that works best.