Bay Biosciences provides high quality, clinical grade fresh frozen Biliary Tract Cancer (BTC) Adenocarcinoma tumor tissue specimens, with matched cryogenically preserved sera (serum), plasma and peripheral blood mononuclear cells (PBMC) biofluid samples.  

Moreover, The serum and plasma samples are processed from unique patients whole blood following customized protocols, from unique biliary tract cancer patients to a valued pharmaceutical customer for research, diagnostics, development and drug discovery.

Biliary Tract Cancer

Biliary tract cancer, also known as cholangiocarcinoma, is a rare adenocarcinoma that occurs in a bile duct; consequently, it often causes jaundice, pruritus, and weight loss. Additionally, the lesion may be papillary or flat and ulcerated. Furthermore, biliary tract cancers (BTCs) are rare and have a poor prognosis; thus, the tumor is often un-resectable at diagnosis.

The bile ducts, on the other hand, are a series of thin tubes that go from the liver to the small intestine. Their major job is to move a fluid called bile from the liver and gallbladder into the small intestine, where it, in turn, helps digest the fats in food.

Most bile duct cancers, or cholangiocarcinomas, are adenocarcinomas, which are cancers that start in glandular cells. Specifically, bile duct adenocarcinomas start in the mucous gland cells that line the inside of the ducts.

Types of Bile Duct Cancers

Cancer can start in any part of the bile duct system; consequently, depending on where the cancers are, they are grouped mainly into the following three types:

• 1. Intrahepatic bile duct cancers
• 2. Perihilar, also known as hilar bile duct cancers
• 3. Distal bile duct cancers

Intrahepatic Bile Duct Cancers

These cancers start in the smaller bile duct branches inside the liver. However, sometimes they’re confused with cancers that start in the liver cells, which are called hepatocellular carcinomas; indeed, these are often treated the same way.

Perihilar or Hilar Bile Duct Cancers

In addition, perihilar cancers start at the hilum, where the left and right hepatic ducts have joined and are just leaving the liver. Consequently, these are also called Klatskin tumors. Furthermore, perihilar cancers are grouped with distal bile duct cancers as extrahepatic bile duct cancers.

Distal Bile Duct Cancers

Distal bile duct cancers develop in the lower portion of the bile duct, near the small intestine. Like perihilar tumors, they are classified as extrahepatic bile duct cancers because they originate outside the liver.

To support translational research, Bay Biosciences provides comprehensive clinical information with its biliary tract cancer samples. Available data may include genetic profiling results for biomarkers such as KRAS, EGFR, IDH, FGFR, and BAP1, along with liver function test (LFT) results, including alkaline phosphatase, AST, ALT, and GGT, when available.

Researchers can also request biopsy reports, pathology annotations, and relevant patient clinical histories to enhance drug discovery, biomarker identification, and therapeutic development. In addition, matched serum and plasma samples can be processed according to customized collection and handling protocols that meet specific research requirements.

Bay Biosciences is committed to supplying high-quality, customizable human biospecimens and clinically annotated sample collections to support pharmaceutical, biotechnology, and academic research programs.

• 日本のお客様は、ベイバイオサイエンスジャパンBay Biosciences Japanまたはhttp://baybiosciences-jp.com/contact/までご連絡ください。