Bay Biosciences provides high quality, clinical grade cryopreserved (-80°C) human Bronchoalveolar Lavage Fluid (BAL) cell pellets from untreated mild Asthma patients. The BAL fluid samples were processed into cell pellets using customized processing protocols provided by the researcher. The BAL fluid was centrifuged to yield the cell pellets, which were later suspended in freezing media (media + 10-20% FBS +10% DMSO) and the Bronchoalveolar lavage cell pellets were cryogenically preserved at, – 80 °C.
Asthma is a chronic long-term inflammatory respiratory disease of the airways of the lungs. It makes breathing difficult and can make some physical activities challenging or even impossible. It causes the airways to get inflamed and narrow, making it difficult to breathe. Severe asthma or bronchial asthma can cause trouble talking or being active.
Normally when we breath the air goes through our nose our mouth and down into our throat and into the airways, eventually making it to the lungs. There are many small air passages in the lungs that help deliver oxygen from the air into the bloodstream. Asthma symptoms occur when the lining of the airways swell and the muscles around them tighten. Mucus then fills the airways, further reducing the amount of air that can pass through. These conditions can then bring on an asthma “attack,” the coughing and tightness in the chest that’s typical of asthma.
Asthma Symptoms
There are three major signs of asthma:
- Airway blockage: When you breathe as usual, the bands of muscle around your airways are relaxed, and air moves freely. But when you have asthma, the muscles tighten. It’s harder for the air to pass through.
- Inflammation: Asthma causes red, swollen bronchial tubes in the lungs. This inflammation can damage the lungs.
- Airway irritability: Patients with asthma have sensitive airways that tend to overreact and narrow when they come into contact with even slight triggers.
These problems may further cause the following symptoms:
- Wheezing
- Severe cough, especially at night and during exercise
- Tightness, pain, pressure in the chest
- Shortness of breath
- Dizziness
- Difficulty talking
- Trouble sleeping because of breathing problems
- Anxiousness or panic
- Fatigue
Bronchoalveolar Lavage (BAL) Fluid
Bronchoalveolar lavage (BAL) Fluid is also known as bronchoalveolar wash. Bronchoalveolar Lavage or BAL is a minimally invasive is a procedure that involves installation of sterile normal saline into a subsegment of the lung, followed by suction and collection of the installed fluid for analysis. Bronchoalveolar Lavage procedure is used for the diagnostics of the diseases of the lower respiratory system. BAL sampling is used primarily to detect cytological abnormalities such as cancer, or to identify infectious pathogens. In this procedure a bronchoscope is passed through the mouth or nose into an appropriate airway in the lungs and a measured amount of sterile saline fluid is introduced and the affected area is washed with the fluid and then the same fluid is collected back with a suction device and suction tubing for examination.
Majority of pathological diseases occur within the lungs at the alveolar level. Bronchoalveolar lavage (BAL) allows for the collection of the alveolar milieu and further analysis of its composition. Bronchoalveolar lavage (BAL) is used for diagnosis of opportunistic and atypical respiratory infections in immunocompromised patients, unexplained radiographic pulmonary infiltrates or hypoxemia. Bronchoalveolar lavage (BAL) reveals specific information in disorders such as pulmonary alveolar proteinosis, Langerhans-cell histiocytosis, alveolar hemorrhage, malignant infiltration, hypersensitivity pneumonitis, pneumoconiosis, other infiltrative processes, sarcoidosis, asthma, chronic obstructive pulmonary disease (COPD), and exposure to dusts and chemicals, mesothelioma, the presence of malignant cells and Asbestos exposure.
Bronchoalveolar lavage (BAL) is used for analyzing the lung parenchyma. Cytology, Gram staining, and culturing can be performed on the fluids collected. Biomarkers can be analyzed from BAL fluids, which can assist the researchers and doctors in establishing diagnosis, in refining differential diagnosis, and in the clinical management of the patient and for further research and development.
As a research tool, Bronchoalveolar lavage (BAL) is used to characterize the effectiveness of intravenous drug delivery to the lungs and to improve understanding of lung biology in the distal lung. It is able to collect inflammatory cells and mediators for analysis. Bronchoalveolar lavage (BAL) is invaluable to the understanding of disease states such as sarcoidosis and pulmonary fibrosis.
Detailed clinical data, biomarker information, Spirometry, Peak flow, ENO, CT annotations and patients history associated with the mild asthma Bronchoalveolar lavage (BAL) cell pellet bio-specimens is provided to a valued customer for drug discovery, development and research.
Bay Biosciences is a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens and human bio-fluid collections from cancer (tumor) tissue, cancer sera (serum), cancer plasma, cancer PBMC and human tissue samples from most other therapeutic areas and diseases.
Bay Biosciences maintains and manages it’s own bio-repository, human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and from normal healthy donors available in all formats and types. Our biobank procures and stores fully consented, deidentified and institutional review boards (IRB) approved human tissue samples and matched controls.
All our human human tissue collections, human specimens and human bio-fluids are provided with detailed samples associated patient’s clinical data. This critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers and genetic information. Patient’s data is extremely valuable for researchers and is used to help identify new effective treatments (drug discovery & development) in oncology, other therapeutic areas and diseases. This clinical information is critical to demonstrate their impact, monitor the safety of medicines, testing & diagnostics, and generate new knowledge about the causes of disease and illness.
Bay Biosciences banks wide variety of human tissue samples and biological samples including cryogenically preserved -80°C, fresh, fresh frozen tissue samples, tumor tissue samples, FFPE’s, tissue slides, with matching human bio-fluids, whole blood and blood derived products such as serum, plasma and PBMC’s.
Bay Biosciences is a global leader in collecting and providing human tissue samples according to the researchers specified requirements and customized, tailor made collection protocols. Please contact us anytime to discuss your special research projects and customized human tissue sample requirements.
Bay Biosciences provides human tissue samples (human specimens) from diseased and normal healthy donors; including peripheral whole-blood, amniotic fluid, bronchoalveolar lavage fluid (BAL), sputum, pleural effusion, cerebrospinal fluid (CSF), serum (sera), plasma, peripheral blood mononuclear cells (PBMC’s), saliva, Buffy coat, urine, stool samples, aqueous humor, vitreous humor, kidney stones, renal calculi, nephrolithiasis, urolithiasis and other bodily fluids from most diseases including cancer. We can also procure most human bio-specimens and can do special collections and requests of human samples that are difficult to find. All our human tissue samples are procured through IRB approved clinical protocols and procedures.
In addition to the standard processing protocols Bay Biosciences can also provide human plasma, serum, PBMC bio-fluid samples using custom processing protocols, you can buy donor specific sample collections in higher volumes and specified sample aliquoting from us. Bay Biosciences also provides human samples from normal healthy donors, volunteers, for controls and clinical research, contact us Now.
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