Bay Biosciences provides high quality, clinical grade, fresh frozen sera (serum), plasma and peripheral blood mononuclear cells (PBMC) biofluid samples from patients diagnosed with Atypical Hemolytic Uremic Syndrome (aHUS).

The sera (serum), plasma and PBMC biofluid specimens are processed from atypical hemolytic uremic syndrome (aHUS) patient’s peripheral whole-blood using customized collection and processing protocols. The atypical hemolytic uremic syndrome (aHUS) matched biofluid samples are collected from unique patients diagnosed with atypical hemolytic uremic syndrome (aHUS) and are provided to a valued pharmaceutical customer for research, diagnostics, discovery and drug development.

Detailed clinical data, patient’s history, symptoms, complete blood count (CBC), serology, MRI findings, histopathology information,elevated biomarker levels, genetic and metabolic information associated with atypical hemolytic uremic syndrome (aHUS) specimens is provided to a valued customer for research, development and drug discovery.

The atypical hemolytic uremic syndrome (aHUS) cancer sera (serum), plasma and peripheral blood mononuclear cells (PBMC) biofluids are processed from patients peripheral whole-blood using customized collection and processing protocols.

Atypical Hemolytic Uremic Syndrome (aHUS) Overview

Atypical hemolytic uremic syndrome (aHUS) is a disease that causes blood clots in small blood vessels in the kidneys and other organs. These clots keep blood from getting to the kidneys, which can lead to serious medical problems, including renal (kidney) failure. There’s no cure for atypical hemolytic uremic syndrome, but effective treatment can help manage the disease.

In addition to the renal (kidney) failure, complications from aHUS may include the following:

  • Hemolytic anemia (red blood cells dying faster than the body can develop them)
  • Thrombocytopenia (low blood platelet count)

Atypical hemolytic syndrome is different from “typical” hemolytic uremic syndrome, which is a more common condition. Typical hemolytic uremic syndrome has various different symptoms and causes. Atypical hemolytic uremic syndrome (aHUS) can develop at any age. In children, it affects both male and female gender patients equally. Later in life, more women than men tend to develop it because pregnancy can be a trigger for the disease. Atypical hemolytic uremic syndrome is rare disease. Experts don’t know exactly how many people have it, but some studies say it affects only few patients out of every million in the United States.

Causes of Atypical Hemolytic Uremic Syndrome (aHUS)

Majority of atypical hemolytic uremic syndrome (aHUS) cases happen because of a change called a mutation in a gene. The mutation itself is not enough to cause the disease. The disease symptoms develop after certain things trigger them, such as:

  • Certain medications
  • Certain chronic diseases, such as systemic sclerosis or malignant hypertension
  • Cancer
  • Infection
  • Organ transplant
  • Pregnancy

More than fifty percent of the patients atypical hemolytic uremic syndrome (aHUS) do not have a gene mutation doctors can find. This type of atypical hemolytic uremic syndrome (aHUS ) is called idiopathic, which means the cause is unknown. Scientists think these cases of atypical hemolytic uremic syndrome (aHUS) are due to gene mutations they haven’t been able to identify.

Signs and Symptoms of Atypical Hemolytic Uremic syndrome (aHUS)

Signs and symptoms of atypical hemolytic uremic syndrome (aHUS) typically come on suddenly after a trigger. These flare-ups can be mild or severe. Mild flare-ups may not affect your kidneys, but severe ones can cause kidney failure.

Following are some of the signs and symptoms you may have in the early stages of atypical hemolytic uremic syndrome (aHUS):

  • Weakness and a lack of energy
  • General feeling of being sick

The disease is “progressive,” which means the symptoms will get worse over time, especially if not diagnosed during the early stage. The main organs affected by atypical hemolytic uremic syndrome (aHUS) are the kidneys. Blocked blood flow can also damage other organs in the body such as the brain, liver, lungs, and heart.

Following is the list of common complications of atypical hemolytic uremic syndrome (aHUS):

  • Facial paralysis
  • Double vision
  • High blood pressure (hypertension)
  • Heart disease or heart attack
  • Headaches
  • Kidney damage or failure
  • Seizures

Diagnosis of of Atypical Hemolytic Uremic syndrome (aHUS)

Diagnosis of atypical hemolytic uremic syndrome (aHUS) can be difficult and tricky specially if a patient don’t have a family history of the disease. A nephrologist (kidney doctor) or hematologist (blood doctor) will be most likely to know about atypical hemolytic uremic syndrome (aHUS).

Tests

Following are the common signs atypical hemolytic uremic syndrome (aHUS) usually shown in the diagnostic tests:

  • Hemolytic anemia
  • Low count of platelets (blood cells that help with clotting)
  • Problems with the kidneys

A complete blood count (CBC) test are performed to measure the platelet and red blood cell levels. Your doctor may check how well your kidneys are working with a routine test called eGFR (estimated glomerular filtration rate). It checks the levels of creatinine, a waste product, in your blood. The test works better if you’re over 18. Because aHUS can look a lot like a condition called thrombotic thrombocytopenic purpura (TTP), your doctor will also test your blood for a specific protein called ADAMTS13. If your levels are low, you have TTP instead of aHUS.

Genetic testing can also help your doctor figure out if you have aHUS. But a genetic test won’t always show aHUS because researchers haven’t identified all the genes involved with the disease. 

Biospecimens

biospecimens

Bay Biosciences is a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens, and human bio-fluid collections.

Moreover, human biospecimens are available including tumor tissue, serum, plasma and PBMC samples from most other therapeutic areas.

Furthermore, Bay Biosciences maintains and manages its own biorepository, the human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and likewise normal healthy donors for controls. Additionally, available in all formats and types.

In fact, our biobank procures and stores fully consented, de-identified and institutional review boards (IRB) approved human tissue samples, human biofluids such as serum samples, plasma samples from various diseases and matched controls.

Also, all our human tissue collections, human biospecimens and human biofluids are provided with detailed, samples associated patient’s clinical data.

In fact, this critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers, and genetic information.

Additionally, researchers find the patient’s data associated with the human biospecimens extremely valuable and use it to help identify new effective treatments (drug discovery & development) in oncology, as well as in other therapeutic areas and diseases.

Bay Biosciences banks wide variety of human tissue samples and human biological samples, including fresh frozen human biospecimens cryogenically preserved at – 80°C.

For example fresh frozen tissue samples, tumor tissue samples, formalin-fixed paraffin-embedded (FFPE), tissue slides, with matching human bio-fluids, whole blood and blood-derived products such as human serum, human plasma and human PBMCs.

Bay Biosciences is a global leader in collecting and providing human tissue samples according to the specified requirements and customized, tailor-made collection protocols.

Please contact us anytime to discuss your special research projects and customized human tissue sample requirements.

Types of Biospecimens

Bay Biosciences provides human tissue samples (human specimens) and human biofluids from diseased and normal healthy donors which includes:

Moreover, we can also procure most human biospecimens and human biofluids, special collections and requests for human samples that are difficult to find. All our human tissue samples and human biofluids are procured through IRB-approved clinical protocols and procedures.

In addition to the standard processing protocols, Bay Biosciences can also provide human biofluids such as  human plasma, human serum, and human PBMCs bio-fluid samples using custom processing protocols; you buy donor-specific collections in higher volumes and specified sample aliquots from us.

Bay Biosciences also provides human biospecimens from normal healthy donors; volunteers, for controls and clinical research, Contact us Now.