Bay Biosciences provides high quality, clinical grade, liver biopsy tissue samples, FFPE tissue blocks with matched cryogenically preserved sera (serum), plasma, peripheral blood mononuclear cells (PBMC) biofluid samples from patients diagnosed with Gilbert’s Syndrome.

The sera (serum), plasma and PBMC biofluid specimens are processed from Gilbert’s syndrome patient’s peripheral whole-blood using customized collection and processing protocols.

Biopsy tissue and matched bio-fluid samples are collected from unique patients diagnosed with Gilbert’s syndrome and are provided to a valued pharmaceutical customer for research, development and drug discovery.

The Gilbert’s syndrome, sera (serum), plasma and peripheral blood mononuclear cells (PBMC) biofluids are processed from patients peripheral whole-blood using customized collection and processing protocols.

Gilbert’s Syndrome Overview

Gilbert’s syndrome is an inherited (genetic) liver disorder that affects the body’s ability to process bilirubin. In Gilbert’s syndrome, higher than normal levels of bilirubin build up in the blood.

Bilirubin is yellow liquid waste that occurs naturally as the body breaks down old red blood cells. Bilirubin is found in bile, a digestive liquid produced by the liver that helps the body absorb fat. Your liver is part of the digestive system. It filters toxins from blood, digests fats and stores glucose (a blood sugar) as glycogen to use for energy.

Patients with Gilbert’s syndrome don’t produce enough liver enzymes to keep bilirubin at a normal level. As a result, excess bilirubin builds up in the body. Excess bilirubin is known as hyperbilirubinemia.

According to the NORD Gilbert syndrome is diagnosed more often in males than females and it affects approximately 3 to 7 percent of people in the United States.

Gilbert’s syndrome is genetically inherited condition, which means it’s passed down from parent to child through a change, or mutation, in a gene. Patients with Gilbert’s syndrome inherit a mutated UGT1A1 gene from their parents.

Signs and Symptoms of Gilbert’s Syndrome

Gilbert’s syndrome doesn’t always cause noticeable symptoms. Approximately 1 in 3 people with Gilbert’s syndrome don’t have symptoms. They learn that they have the disease after getting blood tests to check for a different problem.

About thirty percent Gilbert’s syndrome patients may never develop any signs and symptoms. Some of the Gilbert’s syndrome patients may never even know that they have the disease. Most of the times it is diagnosed in early adulthood.

Gilbert’s syndrome can cause the following signs and symptoms:

The signs and symptoms get more exacerbate in patients with Gilbert’s syndrome due to some of the following conditions, that can further increase the bilirubin levels, such as:

  • Being sick
  • Drinking alcohol (Alcohol can raise bilirubin levels in patients with Gilbert’s syndrome)
  • Exposure to cold
  • Having emotional or physical stress
  • Having an infection
  • Fasting and not eating for a long period 
  • Lack of sleep
  • Having periods
  • Not having enough water
  • Over exertion
  • Recovering from surgery
  • Skipping meals
  • Stress
  • Vigorous exercise

Causes of Gilbert’s Syndrome

As mentioned above Gilbert’s syndrome is a genetic condition that’s passed down from the parents parents.

It is caused by a mutation in the UGT1A1 gene. This mutation results in the body producing less bilirubin-UGT, an enzyme that breaks down bilirubin. Without proper amounts of bilirubin-UGT enzyme, the body can’t process bilirubin properly.

Diagnosis of Gilbert’s Syndrome

Usually doctors would test jaundice patients for Gilbert’s syndrome who don’t have other symptoms of a liver problem. Sometimes even if the patient don’t have jaundice the doctors may notice higher levels of bilirubin during a routine liver function blood test.

Doctors may also perform tests such as a liver biopsy, CT scan, ultrasound, or other blood tests to rule out any other medical conditions that could be causing or adding to the abnormal bilirubin levels. Gilbert’s syndrome can develop alongside other liver and blood diseases.

Usually if the liver function blood tests show increased levels of bilirubin, and there is no other evidence of liver disease, the patient is likely be diagnosed with Gilbert’s syndrome. In some cases, genetic test to check for the gene mutation responsible for the Gilberts syndrome is also performed. Certain medications such as rifampin and niacin can cause a rise in bilirubin in Gilbert’s syndrome.

Treatment of Gilbert’s Syndrome

Usually Gilbert’s syndrome don’t require treatment. However, if the patient start to have significant symptoms, including fatigue or nausea, your doctor might prescribe daily phenobarbital (Luminal) to help reduce the total amount of bilirubin in your body.

Following are some of the lifestyle changes Gilbert’s syndrome patients can make, which can help prevent the symptoms:

  • Avoid exertion and long periods of intense exercise: Keep strenuous workouts short (under 10 minutes). Instead get at least 30 minutes of light to moderate exercise everyday.
  • Drink a lot of water: Staying hydrated is very important. This is especially important during exercise, hot weather, and illness.
  • Eat a balanced diet. Eat regularly, don’t skip any meals, and don’t follow any diet plans that recommend fasting or eating only small amounts of calories.
  • Getting plenty of sleep: Try to sleep at least eight hours everyday consistently. 
  • Learning how the medications interact with Gilbert’s syndrome: Some medications, including used to treat cancer, may work differently if someone has Gilbert’s syndrome.
  • Limit alcohol intake: Patients who you have any liver condition, it’s best to avoid alcohol consumption or have very limited amount.
  • Practice relaxation techniques to cope with stress: Listening to music, meditation, practicing yoga, or other activities that help you relax.

 

Biospecimens

biospecimens

Bay Biosciences is a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens, and human bio-fluid collections.

Moreover, human biospecimens are available including tumor tissue, serum, plasma and PBMC Samples from most other therapeutic areas.

Furthermore, Bay Biosciences maintains and manages its own biorepository, the human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and likewise normal healthy donors for controls. Additionally, available in all formats and types.

In fact, our biobank procures and stores fully consented, de-identified and institutional review boards (IRB) approved human tissue samples, human biofluids such as serum samples, plasma samples from various diseases and matched controls.

Also, all our human tissue collections, human biospecimens and human biofluids are provided with detailed, samples associated patient’s clinical data.

In fact, this critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers, and genetic information.

Additionally, researchers find the patient’s data associated with the human biospecimens extremely valuable and use it to help identify new effective treatments (drug discovery & development) in oncology, as well as in other therapeutic areas and diseases.

Bay Biosciences banks wide variety of human tissue samples and human biological samples, including fresh frozen human biospecimens cryogenically preserved at – 80°C.

For example fresh frozen tissue samples, tumor tissue samples, formalin-fixed paraffin-embedded (FFPE), tissue slides, with matching human bio-fluids, whole blood and blood-derived products such as human serum, human plasma and human PBMCs.

Bay Biosciences is a global leader in collecting and providing human tissue samples according to the specified requirements and customized, tailor-made collection protocols.

Please contact us anytime to discuss your special research projects and customized human tissue sample requirements.

Types of Biospecimens

Bay Biosciences provides human tissue samples (human specimens) and human bio-fluids from diseased and normal healthy donors which includes:

  • Firstly, peripheral whole-blood
  • Secondly, amniotic fluid
  • Thirdly, bronchoalveolar lavage fluid (BAL)
  • Next, sputum
  • Also, pleural effusion
  • Moreover, cerebrospinal fluid (CSF)
  • Likewise, serum (sera)
  • In addition, plasma
  • Moreover, peripheral blood mononuclear cells (PBMC) 
  • Furthermore, saliva
  • Next, buffy coat
  • Accordingly, urine
  • For example, Stool samples
  • Also, aqueous humor
  • And, vitreous humor
  • Lastly, kidney stones (renal calculi)
  • Finally, other bodily fluids from most diseases including cancer.

Moreover, we can also procure most human biospecimens and human biofluids, special collections and requests for human samples that are difficult to find. All our human tissue samples and human biofluids are procured through IRB-approved clinical protocols and procedures.

In addition to the standard processing protocols, Bay Biosciences can also provide human biofluids such as  human plasma, human serum, and human PBMCs bio-fluid samples using custom processing protocols. you buy donor-specific collections in higher volumes and specified sample aliquots from us in multiple format and sets.

Bay Biosciences also provides human biospecimens from normal healthy donors; volunteers, for controls and clinical research, Contact us Now.