Bay Biosciences provides high quality, clinical grade, fresh frozen sera (serum), plasma and peripheral blood mononuclear cells (PBMC) biofluid samples from patients diagnosed with Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis.

Moreover, the serum, plasma and PBMCs are processed from ANCA-associated vasculitis patient’s peripheral whole-blood using customized collection and processing protocols. Furthermore, the samples are collected from unique patients diagnosed with ANCA-associated vasculitis and are provided to a valued pharmaceutical customer for research, development and drug development.

In addition, Detailed clinical data, patient’s information associated with ANCA-associated vasculitis specimens is provided to a valued customer for research, development and drug discovery.

ANCA-Associated Vasculitis Overview

The antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV) are three separate conditions which include granulomatosis with polyangiitis, microscopic polyangiitis, eosinophilic granulomatosis with polyangiitis, and renal-limited vasculitis. Serologic classification of AAV into proteinase 3–ANCA disease and myeloperoxidase-ANCA disease correlates with a number of disease characteristics. AAV has a predilection for the kidney, with >75% of patients having renal involvement characterized by rapidly progressive glomerulonephritis. The cause and pathogenesis of AAV are multifactorial and influenced by genetics, environmental factors, and responses of the innate and adaptive immune system.

What is ANCA-Associated Vasculitis?

Anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis describes a group of rare diseases that cause inflammation in small- to medium-sized blood vessels in your body.

Consequently, this inflammation can reduce blood flow, impacting the organs and how they work. Moreover, the exact cause of ANCA-associated vasculitis is currently unknown, but researchers think it is a combination of genetic and environmental factors.

Sub Types

Following are the mots common subtypes of ANCA-Associated vasculitis:

Granulomatosis with Polyangiitis (GPA)

For instance, granulomatosis with polyangiitis (GPA) is a disease resulting from inflammation of the blood vessels. In particular, in GPA, immune cells can cluster to form what is called a granuloma. As a result, the lungs, kidney, sinuses, ears, nose, and throat are often affected.

Microscopic Polyangiitis (MPA)

On the other hand, microscopic polyangiitis (MPA) shares similarities with GPA, but granulomas don’t form. Furthermore, the impact on the kidneys may be more severe, and people with MPA may be more likely to have bleeding in their lungs.

How Does ANCA-Associated Vasculitis Affect the Body?

GPA and MPA can impact many different parts of your body. Furthermore, this diagram can help you understand some of the signs and symptoms of GPA and MPA. For instance, for ~50% of people, even in remission,† vasculitis symptoms are debilitating.

Therefore, it is important to keep track of signs and symptoms and discuss them with your doctor. In addition, keeping a notebook or journal can help you have an organized conversation with your doctors to take control of your treatment.

Moreover, signs and/or symptoms can be persistent. Although relapse is common with GPA and MPA, it often causes significant harm.

Signs and Symptoms of ANCA-Associated Vasculitis 

Diagnosis of ANCA-Associated Vasculitis 

Since GPA and MPA share many signs and symptoms with other diseases, doctors may find diagnosing them tricky. Nevertheless, early diagnosis is extremely important to creating a treatment plan that can help manage these conditions.

In addition, following are some of the tests performed to confirm a potential GPA or MPA diagnosis:

  • Firstly, a physical examination to evaluate organ involvement and rule out other illnesses that may look similar.
  • Moreover, blood tests for anti-neutrophil cytoplasmic antibodies (ANCA), which can support a suspected diagnosis. However, the diagnosis of GPA and MPA can’t be shown by a blood test alone.
  • Additionally, urine tests to determine if your kidneys have been impacted.
  • Furthermore, other tests such as X-rays, computed tomography (CT) scans, biopsies, or magnetic resonance (MR) scans, which can help identify abnormalities in affected areas such as the lungs.

Consequently, depending on how GPA or MPA has impacted your body, you may need to see different types of doctors, such as a rheumatologist or nephrologist, to help manage your symptoms.

Finally, once a diagnosis of GPA or MPA is suspected, a tissue sample of the affected area known as a biopsy may be performed to confirm the presence of vasculitis. However, biopsies can be helpful when trying to understand if an organ is impacted by GPA or MPA.

Biospecimens

biospecimens

Bay Biosciences is a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens, and human bio-fluid collections.

Moreover, human biospecimens are available including tumor tissue, serum, plasma and PBMC samples from most other therapeutic areas.

Furthermore, Bay Biosciences maintains and manages its own biorepository, the human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and likewise normal healthy donors for controls. Additionally, available in all formats and types.

In fact, our biobank procures and stores fully consented, de-identified and institutional review boards (IRB) approved human tissue samples, human biofluids such as serum samples, plasma samples from various diseases and matched controls.

Also, all our human tissue collections, human biospecimens and human biofluids are provided with detailed, samples associated patient’s clinical data.

In fact, this critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers, and genetic information.

Additionally, researchers find the patient’s data associated with the human biospecimens extremely valuable and use it to help identify new effective treatments (drug discovery & development) in oncology, as well as in other therapeutic areas and diseases.

Bay Biosciences banks wide variety of human tissue samples and human biological samples, including fresh frozen human biospecimens cryogenically preserved at – 80°C.

For example fresh frozen tissue samples, tumor tissue samples, formalin-fixed paraffin-embedded (FFPE), tissue slides, with matching human bio-fluids, whole blood and blood-derived products such as human serum, human plasma and human PBMCs.

Bay Biosciences is a global leader in collecting and providing human tissue samples according to the specified requirements and customized, tailor-made collection protocols.

Please contact us anytime to discuss your special research projects and customized human tissue sample requirements.

Types of Biospecimens

Bay Biosciences provides human tissue samples (human specimens) and human biofluids from diseased and normal healthy donors which includes:

Moreover, we can also procure most human biospecimens and human biofluids, special collections and requests for human samples that are difficult to find. All our human tissue samples and human biofluids are procured through IRB-approved clinical protocols and procedures.

In addition to the standard processing protocols, Bay Biosciences can also provide human biofluids such as  human plasma, human serum, and human PBMCs bio-fluid samples using custom processing protocols; you buy donor-specific collections in higher volumes and specified sample aliquots from us.

Bay Biosciences also provides human biospecimens from normal healthy donors; volunteers, for controls and clinical research, Contact us Now.