Bay Biosciences provides high quality, clinical grade bio-samples, cryogenically preserved tumor tissue, FFPE blocks, sera (serum), plasma and peripheral blood mononuclear cells (PBMC) biofluid specimens from patients diagnosed with Angiosarcoma.
The sera (serum), plasma and peripheral blood mononuclear cells (PBMC) biofluid samples are processed from patient’s peripheral whole-blood using customized collection and processing protocols. The Angiosarcoma bio-specimens are collected from unique patients diagnosed with Angiosarcoma and are provided to a valued pharmaceutical customer for translational research, genomics, proteomics and biomarker research, drug discovery and development.
Angiosarcoma Overview
Angiosarcoma (AS) is a rare type of cancer that forms in the lining of the blood vessels and lymph vessels. Lymph vessels, which are part of the human immune system that collects bacteria, viruses and waste products from the body and dispose of them.
Angiosarcoma is a cancer of the endothelial cells that line the walls of blood vessels or lymphatic vessels. It primarily affects older adults, Angiosarcoma can occur anywhere in the body, but it most often occurs in the skin on the head and neck. Most tumors of visceral blood and lymphatic vessels walls are cancerous (malignant). Because these cancers are carried by the blood flow or lymphatic flow, they can more easily metastasize to distant sites, particularly the liver and lungs. It may occur at any site but most commonly involves skin, soft tissue, breast, and liver. An angiosarcoma (AS) is an uncommon malignant neoplasm characterized by rapidly proliferating, extensively infiltrating anaplastic cells derived from blood vessels and lining irregular blood-filled spaces. Specialists apply the term angiosarcoma to a wide range of malignant endothelial vascular neoplasms that affect a variety of sites. Angiosarcomas are aggressive and tend to recur locally, spread widely, and have a high rate of lymph node and systemic metastases, therefore the rate of tumor-related death in Angiosarcoma (AS) is high.
Angiosarcoma (AS) Symptoms
Angiosarcoma signs and symptoms may vary based on where the cancer occurs.
Angiosarcoma that affects the skin
Most often, angiosarcoma occurs in the skin on the head and neck, particularly the scalp. Signs and symptoms of this form of angiosarcoma include:
- A raised, purplish area of skin that looks like a bruise
- A bruise-like lesion that grows larger over time
- A lesion that may bleed when scratched or bumped
- Swelling in the surrounding skin
Angiosarcoma that affects organs
When angiosarcoma affects organs, such as the liver or the heart, it often causes pain. Other symptoms depend on the location of the angiosarcoma. Angiosarcomas show signs of hemorrhage and necrosis. Pathologically, tumor cells show increased nuclear to cytoplasm ratio, nuclear hyperchromasia, nuclear pleomorphism and high mitotic activity (tumor cell proliferation).
Angiosarcoma (AS) Causes
It’s not clear what causes most angiosarcomas, though doctors have identified factors that may increase the risk of the disease. Researchers know that something happens that causes a cell in the lining of a blood vessel or lymph vessel to develop an error (mutation) in its genetic code. The mutation tells the cell to grow quickly, making more abnormal cells. The abnormal cells continue living when other cells would die. The result is a buildup of abnormal cells that grows from the affected blood vessel or lymphatic vessels. With time, cells may break off and spread (metastasize) to other areas of the body.
Angiosarcoma (AS) Risk Factors
Factors that may increase the risk of Angiosarcoma include:
- Radiation therapy: Treatment with radiation for cancer or other conditions may increase the risk of angiosarcoma. A rare complication of radiation therapy, angiosarcoma typically occurs five to 10 years after treatment.
- Swelling caused by lymph vessel damage (lymphedema): Lymphedema is swelling caused by a backup of lymph fluid that occurs when the lymphatic system is blocked or damaged. Lymphedema is a risk whenever lymph nodes are removed during surgery, a technique that’s often used to treat cancer. Lymphedema can also occur in response to infection or other conditions.
- Chemicals: Liver angiosarcoma has been linked to exposure to several chemicals, including vinyl chloride and arsenic.
Detailed clinical data, MRI/CT/PET scan, elevated biomarker levels, genetic and metabolic information, tumor tissue biopsy, ultrasound, pathology annotations associated with the Angiosarcoma patient’s specimens is provided to a valued customer for drug discover, development and research. The Angiosarcoma sera (serum), plasma and PBMC biofluid samples are processed from patients peripheral whole-blood using customized collection and processing protocols provided by the researcher.
Bay Biosciences is a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens and human bio-fluid collections from cancer (tumor) tissue, cancer sera (serum), cancer plasma, cancer PBMC and human tissue samples from most other therapeutic areas and diseases.
Bay Biosciences maintains and manages it’s own bio-repository, human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and from normal healthy donors available in all formats and types. Our biobank procures and stores fully consented, deidentified and institutional review boards (IRB) approved human tissue samples and matched controls.
All our human human tissue collections, human specimens and human bio-fluids are provided with detailed samples associated patient’s clinical data. This critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers and genetic information. Patient’s data is extremely valuable for researchers and is used to help identify new effective treatments (drug discovery & development) in oncology, other therapeutic areas and diseases. This clinical information is critical to demonstrate their impact, monitor the safety of medicines, testing & diagnostics, and generate new knowledge about the causes of disease and illness.
Bay Biosciences banks wide variety of human tissue samples and biological samples including cryogenically preserved -80°C, fresh, fresh frozen tissue samples, tumor tissue samples, FFPE’s, tissue slides, with matching human bio-fluids, whole blood and blood derived products such as serum, plasma and PBMC’s.
Bay Biosciences is a global leader in collecting and providing human tissue samples according to the researchers specified requirements and customized, tailor made collection protocols. Please contact us anytime to discuss your special research projects and customized human tissue sample requirements.
Bay Biosciences provides human tissue samples (human specimens) from diseased and normal healthy donors; including peripheral whole-blood, amniotic fluid, bronchoalveolar lavage fluid (BAL), sputum, pleural effusion, cerebrospinal fluid (CSF), serum (sera), plasma, peripheral blood mononuclear cells (PBMC’s), saliva, Buffy coat, urine, stool samples, aqueous humor, vitreous humor, kidney stones, renal calculi, nephrolithiasis, urolithiasis and other bodily fluids from most diseases including cancer. We can also procure most human bio-specimens and can do special collections and requests of human samples that are difficult to find. All our human tissue samples are procured through IRB approved clinical protocols and procedures.
In addition to the standard processing protocols Bay Biosciences can also provide human plasma, serum, PBMC bio-fluid samples using custom processing protocols, you can buy donor specific sample collections in higher volumes and specified sample aliquoting from us. Bay Biosciences also provides human samples from normal healthy donors, volunteers, for controls and clinical research, contact us Now.
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