Bay Biosciences provides high quality, clinical grade, frozen aqueous humor samples, with matched cryogenically preserved sera (serum) and plasma biofluid samples from healthy donors for research.
The aqueous humor fluid samples K3-EDTA plasma, sera (serum) and PBMC biofluid specimens are processed from unique healthy donors, peripheral whole-blood using customized collection and processing protocols.
Aqueous Humor Fluid Overview
The Aqueous humor is a thin, watery fluid located in the anterior and posterior chambers of the human eye. The anterior chamber lies between the iris (colored part of the eye) and the inner surface of the cornea (the front of the eye).
The posterior chamber is located behind the iris and in front of the lens. In addition to supporting the shape of this area, aqueous supplies nutrients and nourishment to parts of the eye that lack blood supply. It also removes waste.
Improper drainage of the aqueous humor can cause an increase in intraocular pressure (pressure inside the eye). This increase can result in loss of vision or contribute to the development of glaucoma. Issues with aqueous humor drainage can be treated surgically.
Aqueous humor is the clear liquid inside the front part of the eye. It nourishes the eye and keeps it inflated. The eye constantly produces a small amount of aqueous humor while an equal amount flows out through the trabecular meshwork in the drainage angle.
Imbalances in the creation and drainage of aqueous humor can lead to high intraocular pressure (eye pressure or IOP). High intraocular pressure is a major part of glaucoma and can damage vision.
Function of the Aqueous Humor
Several eye structures that are located in the anterior and posterior chambers of the eye don’t have a blood supply. Instead, they rely on aqueous humor for nourishment.
Aqueous fluid also removes waste from the eye with its constant flow through the anterior and posterior chambers.
While providing nourishment and removing waste, aqueous humor is also responsible for maintaining proper, balanced pressure within the eye. This may seem like a simple task, but it’s incredibly important for eye health.
Imbalances in the creation and drainage of aqueous humor can lead to high intraocular pressure, also called IOP or eye pressure. High eye pressure is a main factor of glaucoma, a potentially sight-threatening condition.
The aqueous humor is what fills up the eye’s anterior and posterior chamber. It is also responsible for the eye’s shape.
Formation of the aqueous humor is correlated with and sensitive to your body’s circadian rhythm. It is a water-like fluid between the cornea and iris.
The aqueous humor’s main job is to:
- Allow the cornea to expand, so it can protect the eye against dust, particles, and bacteria that can cause harm.
- Preserve ocular pressure.
- Transport nutrients, including vitamin C.
The aqueous humor is produced by a part of the eye called the ciliary body, located above the eye’s lens. The aqueous humor must enter and be drained from the eye at an equal rate, exiting the eye from a structure called the trabecular meshwork. This tissue lets fluid drain through it.
Consistent secretion of the aqueous humor is important to your eye’s health.
How to Maintain Healthy Aqueous Humor?
The aqueous humor needs to flow free continuously. Interference with the proper flow can lead to intraocular pressure, which can result in optic nerve damage and vision impairment. Regular eye check-ups can help your doctor detect any issues with the aqueous humor and curate an adequate remedy.
Various lifestyle choices can affect the aqueous humor’s health. The better your health, the more you can reduce the risk of intraocular pressure inside your eye. Some helpful tips:
- Always wear safety glasses if you’re working in a field that could affect the eye. For example, if you’re a carpenter, or work with a lot of dust, grains, or wind, invest in a good pair of safety glasses.
- Exercise regularly to relieve eye pressure naturally.
- Have regular (annual) eye checkups with an optometrist or ophthalmologist.
- Regulate caffeine intake.
- Try meditation and relaxation techniques.
Even if you take excellent care of your eye health, increased intraocular pressure is linked with age, conditions like diabetes, a family history of glaucoma, and certain ethnicities.
Aqueous Humor Flow
The flow of aqueous humor begins in its production by the ciliary body, in the posterior chamber of the eye. From the ciliary body, aqueous humor flows through the pupil and into the anterior chamber.
Aqueous humor then leaves the anterior chamber through a structure called the drainage angle. Once inside the drainage angle, the aqueous fluid leaves the eye through a spongy tissue called the trabecular meshwork.
The trabecular meshwork moves the liquid into a drainage canal, called Schlemm’s canal, where the aqueous humor then drains into the eye’s circulatory system.
Aqueous Humor and Glaucoma
Imbalances in the amount of aqueous produced and aqueous drained can lead to ocular hypertension, or high eye pressure. This can occur because of an overproduction of aqueous humor or an insufficient drainage of it.
As mentioned earlier, aqueous humor leaves the eye through the drainage angle. It’s possible for the drainage angle to be “open” or “closed,” meaning the passageway is narrow. The narrower the drainage angle becomes, the more difficult it is for the aqueous humor to drain.
When the drainage canal narrows to the point where aqueous can’t drain effectively, it results in narrow-angle glaucoma: High eye pressure caused by a closed drainage angle. This type of glaucoma is rare and may occur gradually or suddenly (called acute angle closure).
It’s also possible to experience poor aqueous drainage even when the drainage angle is wide open.
This is known as open angle open glaucoma and is caused by a blockage in the drainage canals, like the trabecular meshwork or Schlemm’s canal, rather than the drainage angle.
Open-angle glaucoma typically develops slowly and is the most common type of glaucoma, representing at least 90% of cases.
Both types of glaucoma, if left untreated, can damage vision and eventually cause blindness
The posterior chamber is located behind the iris and in front of the lens. In addition to supporting the shape of this area, aqueous supplies nutrients and nourishment to parts of the eye that lack blood supply. It also removes waste.
Improper drainage of the aqueous humor can cause an increase in intraocular pressure (pressure inside the eye). This increase can result in loss of vision or contribute to the development of glaucoma. Issues with aqueous humor drainage can be treated surgically.
Bay Biosciences is a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens, and human bio-fluid collections.
Samples available include cancer (tumor) tissue, cancer serum, cancer plasma, cancer, peripheral blood mononuclear cells (PBMC). and human tissue samples from most other therapeutic areas and diseases.
Bay Biosciences maintains and manages its own biorepository, the human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and from normal healthy donors available in all formats and types.
Our biobank procures and stores fully consented, deidentified and institutional review boards (IRB) approved human tissue samples and matched controls.
All our human tissue collections, human specimens and human bio-fluids are provided with detailed, samples associated patient’s clinical data.
This critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers, and genetic information.
Patient’s data is extremely valuable for researchers and is used to help identify new effective treatments (drug discovery & development) in oncology, and other therapeutic areas and diseases.
Bay Biosciences banks wide variety of human tissue samples and biological samples, including cryogenically preserved at – 80°C.
Including fresh frozen tissue samples, tumor tissue samples, formalin-fixed paraffin-embedded (FFPE), tissue slides, with matching human bio-fluids, whole blood and blood-derived products such as serum, plasma and PBMC.
Bay Biosciences is a global leader in collecting and providing human tissue samples according to the specified requirements and customized, tailor-made collection protocols.
Please contact us anytime to discuss your special research projects and customized human tissue sample requirements.
Bay Biosciences provides human tissue samples (human specimens) from diseased and normal healthy donors which includes:
- Peripheral whole-blood
- Amniotic fluid
- Bronchoalveolar lavage fluid (BAL)
- Sputum
- Pleural effusion
- Cerebrospinal fluid (CSF)
- Serum (sera)
- Plasma
- Peripheral blood mononuclear cells (PBMC)
- Saliva
- Buffy coat
- Urine
- Stool samples
- Aqueous humor
- Vitreous humor
- Kidney stones (renal calculi)
- Other bodily fluids from most diseases including cancer.
We can also procure most human bio-specimens, special collections and requests for human samples that are difficult to find. All our human tissue samples are procured through IRB-approved clinical protocols and procedures.
In addition to the standard processing protocols, Bay Biosciences can also provide human plasma, serum, and PBMC bio-fluid samples using custom processing protocols; you buy donor-specific collections in higher volumes and specified sample aliquots from us.
Bay Biosciences also provides human samples from normal healthy donors; volunteers, for controls and clinical research, contact us Now.
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