Aqueous Humor Samples for Research

Bay Biosciences provides fresh frozen human aqueous humor samples with detailed clinical annotations to a pharmaceutical customer for research. 

Aqueous Humor Overview

The aqueous humor is a clear, water-like fluid similar to  plasma, containing low protein concentrations. moreover, located inside the front part of the eye. It nourishes the eye and keeps it inflated.

Additionally, the eye constantly produces a small amount of aqueous humor. Specifically, it is secreted from the ciliary body (a structure supporting the lens) while an equal amount flows out through the trabecular meshwork in the drainage angle.

Aqueous Humor Anatomy

Regarding eye anatomy, aqueous humor is found in the anterior and posterior chambers of the eye.

Additionally, the anterior chamber is located between the cornea (the front layer of the eye) and the iris (the colored part of the eye). Meanwhile, the posterior chamber lies between the iris and the front of the lens.

Furthermore, aqueous humor consists almost entirely of water — 99.9% to be exact. The remaining 0.01% is made up of nutrients such as sugars, proteins and vitamins.

Location of the Aqueous Humor

Your eye has an anterior chamber, which is the area between your lens and cornea. Your eye also has a posterior chamber, which is the area between your lens and iris, which is the colored part of your eye.

In the posterior chamber, the ciliary body makes aqueous humor. Subsequently, that fluid moves through your pupil to the front of your eye and then drains out of your eye into your bloodstream. Finally, it leaves your eye through the scleral venous sinus.

Aqueous Humor Function

Several eye structures that are located in the anterior and posterior chambers of the eye don’t have a blood supply. Instead, they rely on aqueous humor for nourishment.

Furthermore, aqueous fluid also removes waste from the eye with its constant flow through the anterior and posterior chambers.

In addition, while providing nourishment and removing waste, aqueous humor is also responsible for maintaining proper, balanced pressure within the eye. This may seem like a simple task, but it’s incredibly important for eye health.

Moreover, imbalances in the creation and drainage of aqueous humor can lead to high intraocular pressure, also called IOP or eye pressure. Consequently, high eye pressure is a main factor of glaucoma, a potentially sight-threatening condition.

Aqueous Humor Function

Aqueous Humor Flow

The flow of aqueous humor begins in its production by the ciliary body, in the posterior chamber of the eye. From the ciliary body, aqueous humor flows through the pupil and into the anterior chamber.

Aqueous humor then leaves the anterior chamber through a structure called the drainage angle. Once inside the drainage angle, the aqueous fluid leaves the eye through a spongy tissue called the trabecular meshwork.

The trabecular meshwork moves the liquid into a drainage canal, called Schlemm’s canal, where the aqueous humor then drains into the eye’s circulatory system.

Conditions and Disorder

It’s important to have regular eye exams because ultimately, finding any kind of condition early is best for treatments and outcomes.

Following are several eye conditions that affect or relate to aqueous and vitreous humors, including:

  • Glaucoma: Firstly, glaucoma refers to damage of the optic nerve, which an increased aqueous fluid build-up and high pressure in your eye causes. Consequently, glaucoma is the second-leading cause of blindness in the world.

  • Posterior vitreous detachment: Next, as people get older, their vitreous humor gets thinner and eventually loosens from their retinas. When this happens, for instance, you may experience flashes and floaters, which may be due to a posterior vitreous detachment. Furthermore, some people may develop a retinal tear or detachment, therefore everyone who experiences new flashes and floaters should have their eyes examined.
  • Uveitis: Uveitis refers to a group of diseases that cause red eye, eye pain and inflammation. Moreover, it can affect your retina, uvea and sclera. Specifically, the uvea is the part of the eye that contains the ciliary body. In addition, the ciliary body is involved in making the aqueous humor.
  • Age-related macular degeneration (AMD): Consequently, the changes in the vitreous humor as people get older can be a factor in AMD. This condition, in fact, is the leading cause of vision loss in people older than 50. Furthermore, iIt affects their macula, the part of the retina that handles central vision.
  • Macular hole: Additionally, holes in the macula happen because of trauma or because of another medical condition. Typically, it usually only happens in one eye. One treatment, for instance, is a vitrectomy, which removes the vitreous humor and replaces it with another substance, like a gas.

Biospecimens

Bay Biosciences is a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens, and human bio-fluid collections.

Samples available include cancer (tumor) tissue, cancer serum, cancer plasma, cancer, peripheral blood mononuclear cells (PBMC). and human tissue samples from most other therapeutic areas and diseases.

Bay Biosciences maintains and manages its own biorepository, the human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and from normal healthy donors available in all formats and types.

In fact, our biobank procures and stores fully consented, de-identified and institutional review boards (IRB) approved human tissue samples and matched controls.

Also, all our human tissue collections, human specimens and human bio-fluids are provided with detailed, samples associated patient’s clinical data.

So this critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers, and genetic information.

Additionally, patient’s data is extremely valuable for researchers and is used to help identify new effective treatments (drug discovery & development) in oncology, and other therapeutic areas and diseases.

Bay Biosciences banks wide variety of human tissue samples and biological samples, including cryogenically preserved at – 80°C.

For example fresh frozen tissue samples, tumor tissue samples, formalin-fixed paraffin-embedded (FFPE), tissue slides, with matching human bio-fluids, whole blood and blood-derived products such as serum, plasma and PBMC.

Bay Biosciences is a global leader in collecting and providing human tissue samples according to the specified requirements and customized, tailor-made collection protocols.

Please contact us anytime to discuss your special research projects and customized human tissue sample requirements.

Types of Biospecimens

Bay Biosciences provides human tissue samples (human specimens) from diseased and normal healthy donors which includes:

Moreover, we can also procure most human bio-specimens, special collections and requests for human samples that are difficult to find. All our human tissue samples are procured through IRB-approved clinical protocols and procedures.

In addition to the standard processing protocols, Bay Biosciences can also provide human plasma, serum, and PBMC bio-fluid samples using custom processing protocols; you buy donor-specific collections in higher volumes and specified sample aliquots from us.

Bay Biosciences also provides human samples from normal healthy donors; volunteers, for controls and clinical research, contact us Now.

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