Bay Biosciences provides high-quality, frozen sera (serum), EDTA plasma and matched peripheral blood mononuclear cells (PBMC’s), bio-fluids from central nervous system (CNS) patients for research.
The PBMCs, sera (serum) and plasma bio-fluid specimens are processed from central nervous system (CNS) patients peripheral whole-blood using customized collection and processing protocols.
Central Nervous System (CNS) Overview
The central nervous system (CNS) consists of the brain and spinal cord. CNS controls thought, movement, and emotion, as well as breathing, heart rate, hormones, and body temperature.
CNS is referred to as “central” because it combines information from the entire body and coordinates activity across the whole organism.
Facts on the Central Nervous System (CNS)
Following are some key points about the CNS.
- CNS consists of the brain and spinal cord.
- Brain is the most complex organ in the body and uses 20% of the total oxygen we breathe.
- The rain consists of an estimated 100 billion neurons connected to thousands more.
- Brain can be divided into four main lobes: temporal, parietal, occipital, and frontal.
What is Central Nervous System (CNS)
The CNS consists of the brain and spinal cord.
The brain is protected by the skull (the cranial cavity) and the spinal cord travels from the back of the brain, down the center of the spine, stopping in the lumbar region of the lower back.
Spinal cord and the brain are housed within a protective triple-layered membrane called the meninges.
Central nervous system (CNS) has been thoroughly studied by anatomists and physiologists, but it still holds many secrets; it controls our thoughts, movements, emotions, and desires. It also controls our breathing, heart rate, the release of some hormones, body temperature, and much more.
The retina, optic nerve, olfactory nerves, and olfactory epithelium are sometimes considered to be part of the CNS alongside the brain and spinal cord. This is because they connect directly with brain tissue without intermediate nerve fibers.
Brain
The brain is the most complex organ in the human body; the cerebral cortex (the outermost part of the brain and the largest part by volume) contains an estimated 15–33 billion neurons, each of which is connected to thousands of other neurons.
In total, around 100 billion neurons and 1,000 billion glial (support) cells make up the human brain. Our brain uses around 20% of our body’s total energy.
The brain is the central control module of the body and coordinates activity. From physical motion to the secretion of hormones, the creation of memories, and the sensation of emotion.
To carry out these functions, some sections of the brain have dedicated roles. However, many higher functions, reasoning, problem-solving, creativity, involve different areas working together in networks.
Lobes
The brain is split into four lobes:
Temporal Lobe: This is important for processing sensory input and assigning it emotional meaning.
It is also involved in laying down long-term memories. Some aspects of language perception are also housed here.
Occipital Lobe: This is the visual processing region of the brain, housing the visual cortex.
Parietal Lobe: The parietal lobe integrates sensory information including touch, spatial awareness, and navigation.
Touch stimulation from the skin is ultimately sent to the parietal lobe. It also plays a part in language processing.
Frontal Lobe: positioned at the front of the brain, the frontal lobe contains the majority of dopamine-sensitive neurons and is involved in attention, reward, short-term memory, motivation, and planning.
Brain Regions
Next, we will look at some specific brain regions in a little more detail:
Basal ganglia: involved in the control of voluntary motor movements, procedural learning, and decisions about which motor activities to carry out. Diseases that affect this area include Parkison’s disease and Huntington’s disease.
Cerebellum: mostly involved in precise motor control, but also in language and attention. If the cerebellum is damaged, the primary symptom is disrupted motor control, known as ataxia.
Broca’s area: this small area on the left side of the brain (sometimes on the right in left-handed individuals) is important in language processing. When damaged, an individual finds it difficult to speak but can still understand speech. Stuttering is sometimes associated with an underactive Broca’s area.
Corpus callosum: a broad band of nerve fibers that join the left and right hemispheres. It is the largest white matter structure in the brain and allows the two hemispheres to communicate. Dyslexic children have smaller corpus callosums; left-handed people, ambidextrous people, and musicians typically have larger ones.
Medulla oblongata: extending below the skull, it is involved in involuntary functions, such as vomiting, breathing, sneezing, and maintaining the correct blood pressure.
Hypothalamus: sitting just above the brain stem and roughly the size of an almond, the hypothalamus secretes a number of neurohormones and influences body temperature control, thirst, and hunger.
Thalamus: positioned in the center of the brain, the thalamus receives sensory and motor input and relays it to the rest of the cerebral cortex. It is involved in the regulation of consciousness, sleep, awareness, and alertness.
Amygdala: two almond-shaped nuclei deep within the temporal lobe. They are involved in decision-making, memory, and emotional responses; particularly negative emotions.
Spinal Cord
The spinal cord, running almost the full length of the back, carries information between the brain and body, but also carries out other tasks.
From the brainstem, where the spinal cord meets the brain, 31 spinal nerves enter the cord.
Along its length, it connects with the nerves of the peripheral nervous system (PNS) that run in from the skin, muscles, and joints.
Motor commands from the brain travel from the spine to the muscles and sensory information travels from the sensory tissues — such as the skin, toward the spinal cord and finally up to the brain.
Circuits
The spinal cord contains circuits that control certain reflexive responses, such as the involuntary movement your arm might make if your finger was to touch a flame.
The circuits within the spine can also generate more complex movements such as walking. Even without input from the brain, the spinal nerves can coordinate all of the muscles necessary to walk.
For instance, if the brain of a cat is separated from its spine so that its brain has no contact with its body, it will start spontaneously walking when placed on a treadmill. The brain is only required to stop and start the process, or make changes if, for instance, an object appears in your path.
White and Gray Matter
The CNS can be roughly divided into white and gray matter. As a very general rule, the brain consists of an outer cortex of gray matter and an inner area housing tracts of white matter.
Both types of tissue contain glial cells, which protect and support neurons. White matter mostly consists of axons (nerve projections) and oligodendrocytes, a type of glial cell, whereas gray matter consists predominantly of neurons.
Central Glial Cells
Also called neuroglia, glial cells are often called support cells for neurons. In the brain, they outnumber nerve cells 10 to 1.
Without glial cells, developing nerves often lose their way and struggle to form functioning synapses.
Glial cells are found in both the CNS and PNS but each system has different types. The following are brief descriptions of the CNS glial cell types:
Astrocytes: these cells have numerous projections and anchor neurons to their blood supply. They also regulate the local environment by removing excess ions and recycling neurotransmitters.
Oligodendrocytes: responsible for creating the myelin sheath this thin layer coats nerve cells, allowing them to send signals quickly and efficiently.
Ependymal cells: lining the spinal cord and the brain’s ventricles (fluid-filled spaces), these create and secrete cerebrospinal fluid (CSF) and keep it circulating using their whip-like cilia.
Radial glia: act as scaffolding for new nerve cells during the creation of the embryo’s nervous system.
Cranial Nerves
The cranial nerves are 12 pairs of nerves that arise directly from the brain and pass through holes in the skull rather than traveling along the spinal cord. These nerves collect and send information between the brain and parts of the body – mostly the neck and head.
Of these 12 pairs, the olfactory and optic nerves arise from the forebrain and are considered part of the central nervous system:
Olfactory nerves (cranial nerve I): transmit information about odors from the upper section of the nasal cavity to the olfactory bulbs on the base of the brain.
Optic nerves (cranial nerve II): carry visual information from the retina to the primary visual nuclei of the brain. Each optic nerve consists of around 1.7 million nerve fibers.
Diseases of Central Nervous System (CNS)
Below are the major causes of disorders that affect the CNS:
Trauma: depending on the site of the injury, symptoms can vary widely from paralysis to mood disorders.
Infections: some micro-organisms and viruses can invade the CNS; these include fungi, such as cryptococcal meningitis; protozoa, including malaria; bacteria, as is the case with Hansen’s disease (leprosy), or viruses.
Degeneration: in some cases, the spinal cord or brain can degenerate. One example is Parkinson’s disease which involves the gradual degeneration of dopamine-producing cells in the basal ganglia.
Structural defects: the most common examples are birth defects; including anencephaly, where parts of the skull, brain, and scalp are missing at birth.
Tumors: both cancerous and noncancerous tumors can impact parts of the central nervous system. Both types can cause damage and yield an array of symptoms depending on where they develop.
Autoimmune disorders: in some cases, an individual’s immune system can mount an attack on healthy cells. For instance, acute disseminated encephalomyelitis is characterized by an immune response against the brain and spinal cord, attacking myelin (the nerves’ insulation) and, therefore, destroying white matter.
Stroke: a stroke is an interruption of blood supply to the brain; the resulting lack of oxygen causes tissue to die in the affected area.
Difference Between the CNS and Peripheral Nervous System
The term peripheral nervous system (PNS) refers to any part of the nervous system that lies outside of the brain and spinal cord. The CNS is separate from the peripheral nervous system, although the two systems are interconnected.
There are a number of differences between the CNS and PNS; one difference is the size of the cells.
The nerve axons of the CNS, the slender projections of nerve cells that carry impulses, are much shorter. PNS nerve axons can be up to 1 meter long (for instance, the nerve that activates the big toe) whereas, within the CNS, they are rarely longer than a few millimeters.
Major Difference
Another major difference between the CNS and PNS involves regeneration (regrowth of cells). Much of the PNS has the ability to regenerate; if a nerve in your finger is severed, it can regrow. The CNS, however, does not have this ability.
The components of the central nervous system are further split into a myriad of parts. Below, we will describe some of these sections in a little more detail.
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Samples available include cancer (tumor) tissue, cancer serum, cancer plasma, cancer, peripheral blood mononuclear cells (PBMC). and human tissue samples from most other therapeutic areas and diseases.
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Including fresh frozen tissue samples, tumor tissue samples, formalin-fixed paraffin-embedded (FFPE), tissue slides, with matching human bio-fluids, whole blood and blood-derived products such as serum, plasma and PBMC.
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Types of Biospecimens
Bay Biosciences provides human tissue samples (human specimens) from diseased and normal healthy donors which includes:
- Peripheral whole-blood
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- Other bodily fluids from most diseases including cancer.
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