Bay Biosciences provides high quality, clinical grade bio-samples, cryogenically preserved biopsy tissue samples, FFPE tissue blocks with matched sera (serum), plasma,  peripheral blood mononuclear cells (PBMC) and Cerebrospinal Fluid (CSF) bio-fluid specimens from patients diagnosed with Dementia.

The CSF, PBMC, sera (serum) and plasma biofluid samples are processed from demantia patient’s peripheral whole-blood using customized collection and processing protocols from unique patients diagnosed with dementia and are provided to a valued pharmaceutical customer for genomics, proteomics, biomarker, research, development and drug discovery.

Cerebral Spinal Fluid (CSF) Overview

Cerebrospinal fluid (CSF) samples are used for clinical analysis to look for conditions that affect the brain and spine. There are series of laboratory tests performed on CSF samples to diagnose disease. CSF is the clear fluid that cushions and delivers nutrients to the central nervous system (CNS). The CNS consists of the brain and spinal cord. CSF is produced by the choroid plexus (secretary tissue) in the brain and then reabsorbed into the bloodstream. The fluid is completely replaced every few hours. In addition to delivering nutrients, CSF flows around the brain and spinal column, providing protection and carrying away waste.

CSF specimens are collected by performing a lumbar puncture, which is also known as a spinal tap.

Analysis of the sample involves the measurement of and examination for:

  • Fluid pressure
  • Proteins
  • Glucose
  • Red blood cells (RBC)
  • White blood cells (WBC)
  • Chemicals
  • Bacteria
  • Viruses
  • Other invasive organisms or foreign substances

Clinical analysis can include:

  • Measurement of the physical characteristics and appearance of CSF
  • Chemical tests on substances found in the spinal fluid or comparisons to levels of similar substances found in the blood
  • Cell counts and typing of any cells found in the CSF
  • identification of any microorganisms that could cause infectious diseases

CSF is in direct contact with the brain and spine, therefore CSF analysis is more effective than a blood test for understanding central nervous system (CNS) symptoms. However, it’s more difficult to obtain a spinal fluid sample than a blood sample. Entering the spinal canal with a needle requires expert knowledge of the spine’s anatomy and a clear understanding of any underlying brain or spinal conditions that might increase the risk of complications from the procedure.

Diseases detected by Cerebrospinal Fluid (CSF) specimen analysis

Cerebrospinal fluid (CSF) analysis can accurately distinguish between a wide range of Central Nervous System (CNS) diseases that can otherwise be difficult to diagnose.

Conditions found by CSF analysis include:

Infectious Diseases

Viruses, bacteria, fungi, and parasites can all infect the CNS. Certain infections can be found by Cerebrospinal fluid (CSF) analysis. Some of the common CNS infections include:

  • Meningitis
  • Encephalitis
  • Tuberculosis (TB)
  • Fungal infections
  • West Nile Virus
  • Eastern Equine Encephalitis Virus (EEEV)

Hemorrhaging

Internal bleeding can be detected by cerebrospinal fluid (CSF) analysis. However, isolating the exact cause of bleeding may require additional scans or tests. Common causes include high blood pressure, stroke or an aneurysm (enlargement or bulge of an artery).

Immune Response Disorders

Cerebrospinal fluid (CSF) analysis can detect immune response disorders. The immune system can cause damage to the CNS through inflammation, destruction of the myelin sheath around the nerves, and antibody production.

Common diseases of this type include:

  • Guillain-Barre Syndrome 
  • Sarcoidosis
  • Neurosyphilis 
  • Multiple Sclerosis

Neurological Disorders

Cerebrospinal fluid (CSF) analysis can detect neurological disorders.

  • Alzheimer’s Disease
  • Amyotrophic Lateral Sclerosis (ALS)
  • Ataxia
  • Bell’s Palsy
  • Brain Tumors
  • Cerebral Aneurysm
  • Epilepsy and seizures
  • Guillain-Barre Syndrome
  • Meningitis
  • Parkinson’s Disease
  • Frontotemporal Dementia
  • Huntington’s Disease
  • Myasthenia Gravis
  • Multiple Sclerosis
  • Muscular Dystrophy
  • Neurocutaneous Syndromes
  • Stroke
  • Muscular Dystrophy

Tumors

Cerebrospinal fluid (CSF) analysis can detect primary tumors in the brain or spine. It can also detect metastatic cancers that have spread to the central nervous system (CNS) from other body parts.

Biospecimens

biospecimens

Bay Biosciences is a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens, and human bio-fluid collections.

Moreover, human biospecimens are available including tumor tissue, serum, plasma and PBMC samples from most other therapeutic areas.

Furthermore, Bay Biosciences maintains and manages its own biorepository, the human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and likewise normal healthy donors for controls. Additionally, available in all formats and types.

In fact, our biobank procures and stores fully consented, de-identified and institutional review boards (IRB) approved human tissue samples, human biofluids such as serum samples, plasma samples from various diseases and matched controls.

Also, all our human tissue collections, human biospecimens and human biofluids are provided with detailed, samples associated patient’s clinical data.

In fact, this critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers, and genetic information.

Additionally, researchers find the patient’s data associated with the human biospecimens extremely valuable and use it to help identify new effective treatments (drug discovery & development) in oncology, as well as in other therapeutic areas and diseases.

Bay Biosciences banks wide variety of human tissue samples and human biological samples, including fresh frozen human biospecimens cryogenically preserved at – 80°C.

For example fresh frozen tissue samples, tumor tissue samples, formalin-fixed paraffin-embedded (FFPE), tissue slides, with matching human bio-fluids, whole blood and blood-derived products such as human serum, human plasma and human PBMCs.

Bay Biosciences is a global leader in collecting and providing human tissue samples according to the specified requirements and customized, tailor-made collection protocols.

Please contact us anytime to discuss your special research projects and customized human tissue sample requirements.

Types of Biospecimens

Bay Biosciences provides human tissue samples (human specimens) and human biofluids from diseased and normal healthy donors which includes:

Moreover, we can also procure most human biospecimens and human biofluids, special collections and requests for human samples that are difficult to find. All our human tissue samples and human biofluids are procured through IRB-approved clinical protocols and procedures.

In addition to the standard processing protocols, Bay Biosciences can also provide human biofluids such as  human plasma, human serum, and human PBMCs bio-fluid samples using custom processing protocols; you buy donor-specific collections in higher volumes and specified sample aliquots from us.

Bay Biosciences also provides human biospecimens from normal healthy donors; volunteers, for controls and clinical research, Contact us Now.