Bay Biosciences provides 20 million peripheral blood mononuclear cells (PBMC’s) with matched serum (sera) and plasma samples derived from whole blood from 50 unique patients diagnosed with Chronic Lymphocytic Leukemia (CLL). Meeting donor exclusion criteria of samples negative of viral infections, i.e. CLL samples collected are tested negative for HIV, HBV, HCV, HEV, HPV and HCMV infections.
Detailed clinical data and pathology annotations including patient’s data associated with the serum (sera), plasma and PBMC biofluid specimens is provided to a valued pharmaceutical customer for drug development & discovery research.
Chronic Lymphocytic Leukemia (CLL) Overview
Chronic lymphocytic leukemia (CLL) is the most common leukemia in adults. It’s a type of cancer that starts in cells that become certain white blood cells (called lymphocytes) in the bone marrow. Bone marrow is a soft, spongy substance within bones that produces blood cells. The cancer (leukemia) cells start in the bone marrow but then go into the blood. In CLL disease, the leukemia cells often build up slowly. Many patients don’t have any symptoms for few years, but over time, the cells grow and spread to other parts of the body, including the lymph nodes, liver, and spleen.
CLL is the result of various genetic mutations in the DNA of cells that produce blood. The exact cause of these mutations is unknown. These DNA changes occur over the course of a life span, rather than like other genetic changes that are passed down before birth. According to the National Cancer Institute, there will be an estimated over 21,000 new cases of CLL in the United States, causing an estimated over 4,000 deaths.
Some people have a higher risk for developing CLL. The disease is more common in men than women, and it is more likely to affect those over the age of 60. In fact, nearly 80 percent of those newly diagnosed patients with CLL are over 60 years old. Caucasians are also more likely to develop this type of cancer.
In Chronic lymphocytic leukemia (CLL) patients the abnormal cells crowd other types of cells in the bone marrow. This crowding prevents the production of the healthy blood cells, including:
- Red blood cells that carry oxygen
- Other types of white blood cells, such as neutrophils or granulocytes that fight infection.
- Platelets, which are needed for blood to clot
This means that people with CLL may have anemia from low levels of red blood cells and more infections because they do not have enough white blood cells. They may also bruise or bleed more easily because of a low level of platelets. Most often, CLL is diagnosed when too many abnormal lymphocytes are found in the blood, also known as lymphocytosis. However, the same disease can occur when the abnormal lymphocytes are mostly in the lymph nodes but not in the blood. This is called small lymphocytic lymphoma, but it behaves very similarly to CLL.
Types of Chronic Lymphocytic Leukemia (CLL)
There are two general types of CLL based on whether the disease affects B cells or T cells. It is important to find out whether the disease is caused by the overgrowth of T cells or B cells.
- B-cell CLL. More than 95% of people with CLL have the B-cell type. And, about 1% of people with B-cell leukemia have a type called B-cell prolymphocytic leukemia (PLL).
- T-cell prolymphocytic leukemia. The T-cell type of CLL is now called T-cell prolymphocytic leukemia. About 1% of people with CLL have the T-cell type.
There are several subtypes of CLL that differ at the genetic level. This means that the disease may act differently based on the genetic subtype. For example, one person with the B-cell type may have the disease act differently than another person with the B-cell type.
Signs and Symptoms of Chronic Lymphocytic Leukemia (CLL)
Most often, people with CLL have no symptoms. Or, the cause of a symptom may be a different medical condition that is not leukemia. Patients with CLL may experience the following symptoms or signs:
- Swelling of lymph nodes or glands in the neck, under the arms, or in the groin. This is a common symptom that people with CLL usually notice first. The enlarged lymph nodes are not usually painful.
- Discomfort, pain or fullness in the upper left part of the abdomen, caused when the spleen increases in size
- Symptoms often called “B symptoms” that include fever, chills, night sweats, and weight loss
- Recurrent infections
- Night Sweats
- Abnormal bleeding
- Shortness of breath
- Fatigue
- Feeling full despite not eating much
- Malaise, or generally not feeling well
Bay Biosciences is a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens and human bio-fluid collections from cancer (tumor) tissue, cancer serum, cancer plasma cancer PBMC and human tissue samples from most other therapeutic areas and diseases.
Bay Biosciences maintains and manages it’s own bio-repository, human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and from normal healthy donors available in all formats and types. Our biobank procures and stores fully consented, deidentified and institutional review boards (IRB) approved human tissue samples and matched controls.
All our human human tissue collections, human specimens and human bio-fluids are provided with detailed samples associated patient’s clinical data. This critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers and genetic information. Patient’s data is extremely valuable for researchers and is used to help identify new effective treatments (drug discovery & development) in oncology, other therapeutic areas and diseases. This clinical information is critical to demonstrate their impact, monitor the safety of medicines, testing & diagnostics, and generate new knowledge about the causes of disease and illness.
Bay Biosciences banks wide variety of human tissue samples and biological samples including cryogenically preserved -80°C, fresh, fresh frozen tissue samples, tumor tissue samples, FFPE’s, tissue slides, with matching human bio-fluids, whole blood and blood derived products such as serum, plasma and PBMC’s.
Bay Biosciences is a global leader in collecting and providing human tissue samples according to the researchers specified requirements and customized, tailor made collection protocols. Please contact us anytime to discuss your special research projects and customized human tissue sample requirements.
Bay Biosciences provides human tissue samples (human specimens) from diseased and normal healthy donors; including peripheral whole-blood, amniotic fluid, bronchoalveolar lavage fluid (BAL), sputum, pleural effusion, cerebrospinal fluid (CSF), serum (sera), plasma, peripheral blood mononuclear cells (PBMC’s), saliva, Buffy coat, urine, stool samples, aqueous humor, vitreous humor, kidney stones, renal calculi, nephrolithiasis, urolithiasis and other bodily fluids from most diseases including cancer. We can also procure most human bio-specimens and can do special collections and requests of human samples that are difficult to find. All our human tissue samples are procured through IRB approved clinical protocols and procedures.
In addition to the standard processing protocols Bay Biosciences can also provide human plasma, serum, PBMC bio-fluid samples using custom processing protocols, you can buy donor specific sample collections in higher volumes and specified sample aliquoting from us. Bay Biosciences also provides human samples from normal healthy donors, volunteers, for controls and clinical research, contact us Now.
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