Bay Biosciences provides high-quality, fresh frozen, peripheral blood mononuclear cells (PBMC’s), with matched fresh frozen sera (serum), plasma, bio-fluids from patients diagnosed with delusional disorder patients.

The sera (serum), plasma and PBMC bio-fluid specimens are processed from delusional disorder patient’s peripheral whole-blood using customized collection and processing protocols.

Delusional Disorder Overview

Delusional disorder is a mental illness. A person with delusional disorder has one or more delusional thoughts for 1 month or longer. Delusional thoughts do not have to be totally unbelievable or outside the realms of possibility, but they are often not based on reality.

What is Delusional Disorder?

Delusional disorder is a mental illness that causes a person to have delusional thoughts for a prolonged period.

A patient with delusional disorder will have delusional thoughts that are not entirely bizarre or unrealistic. They are usually based on something that could possibly happen to the person in real life, such as someone following or deceiving them.

An individual with delusional disorder will not usually exhibit overtly bizarre behavior, and their delusions often do not affect their ability to function.

Delusional disorder is a rare condition, with estimates suggesting that the probability of a person developing it during their lifetime is as low as 0.05–0.1%.

The condition is equally prevalent across genders. It also has a later general onset than schizophrenia, with which it shares some characteristics.

Signs and Symptoms of Delusional Disorder

A patient with delusional disorder will have illusory thoughts that contradict readily available evidence.

Their delusions are usually not overtly bizarre and could be possible. However, there is often plenty of evidence to suggest that these thoughts are not based on reality.

A person’s delusions often center on an inaccurate interpretation of an external reality.

Some of the more common types of delusions are:

• Bizarre: A person may believe in a phenomenon that is impossible and unrelated to normal life.
•  Thought broadcasting: This type refers to the idea that others are perceiving the person’s thoughts.
• Delusional jealousy: An individual may incorrectly think that their partner is being unfaithful.
• Grandiose: A patient may have inflated self-worth and power and believe that they have great talent or knowledge.
• Persecutory: This occurs when the patient believes that others are attacking or conspiring against them or being obstructive to prevent them from attaining long-term goals.
• Romantic: The individual may believe that another person is in love with them.
• Somatic: The individual may believe that their appearance or bodily functions are grossly abnormal.
• Thought insertion: A person may think that an external source or entity is inserting their thoughts into their mind.

According to researchers, persecutory and jealous delusions are more common in males, whereas romantic delusions are more common in females.

Other than the presence of delusions, a person with delusional disorder does not have impaired functionality, and their behavior is not obviously bizarre.

People with delusional disorder tend not to have hallucinations or other psychotic or marked mood symptoms.

Causes of Delusional Disorder

The exact causes of delusional disorder are not well-understood. However, research suggests that various biological factors, including substance use, medical conditions, and neurological conditions, can cause delusions.

It also indicates that hypersensitivity and ego defense mechanisms, such as reaction formation, projection, and denial, may be linked with delusional disorder.

Other studies have suggested that exposure to trauma could be linked to the development of psychotic episodes.

Treatment and Prevention of Delusional Disorder

Treating delusional disorder is generally challenging. Doctors frequently use antipsychotic medications to treat the disorder, as well as psychological therapies such as cognitive behavioral therapy (CBT).

However, there is some doubt over the effectiveness of these treatments. The authors of a 2015 study state that there is insufficient research to make evidence-based recommendations for treatments for delusional disorder.

They also note that until further studies take place, it is reasonable to offer treatments that are effective in treating other psychotic disorders to people with delusional disorder.

Related and Similar Conditions

Several mental illnesses share similarities with delusional disorder. However, they are all different in various ways. These similar conditions include:

Bipolar Disorder

A person with bipolar disorder can experience unusual changes in mood, energy, activity levels, and concentration. This condition can also affect a person’s ability to carry out tasks.

Common symptoms of bipolar disorder include:

• Changes in activity levels
• Periods of intense emotion — both manic and depressive
• Changes in sleep patterns
• Uncharacteristic behaviors, usually without recognizing their harmful or undesirable effects

Some people with bipolar disorder can experience both manic and depressive symptoms at the same time. A person with more severe bipolar disorder can also experience psychotic symptoms, which can include hallucinations or delusions.

Schizophrenia

The hallmark of schizophrenia is a disrupted thought process. This mental disorder also affects perceptions, social interactions, and emotional responsiveness. Schizophrenia can be severe and disabling.

The symptoms of schizophrenia include the following:

• Cognitive impairment 
• Difficulty in social relationships
• Hallucinations, delusions, and thought disorders
• Reduced expression of emotions
• Motor impairment
• Reduced motivation to accomplish goals 
• Unusual ways of thinking

Obsessive-compulsive disorder (OCD)

Obsessive-compulsive disorder (OCD) is a long lasting, chronic disorder. A person with OCD often has recurring thoughts and obsessions, and they may also feel compelled to repeat certain behaviors.

Common obsessions include the following:

• Aggressive thoughts toward other people and themself
• Fear of germs and contamination
• Having items in perfect order or placing them symmetrically
• Unwanted thoughts regarding taboo subjects, such as harm or sex

Common compulsions and repetitive behaviors include:

• Compulsive counting
• Excessive cleaning
• Placing items in a certain order or a precise, particular way
• Repeatedly checking things, such as whether the door is locked
• Excessive hand washing

Although many people may experience some of the above from time to time, a patient with OCD generally cannot control their thoughts or behaviors, even if they recognize them to be excessive.

Depression

Depression is a very common mental illness and a leading cause of disability worldwide. Depression is more than occasionally feeling sad or unhappy. It is a serious mental health issue that requires both understanding and medical care.

Common symptoms of depression include:

• A feeling of hopelessness
• Changes in sleep and appetite
• Guilty thoughts 
• Loss of energy and lack of interest in activities
• Physical aches and pains
• Suicidal thoughts 
• The inability to concentrate

Delusional thoughts can sometimes occur with different mood episodes.

Summary

Delusional disorder is a mental illness that causes a person to have delusional thoughts. Generally, these delusions are not overly bizarre or unrealistic. However, they are based on an inaccurate interpretation of reality.

Delusions can also occur due to other mental health issues, such as schizophrenia. A person should seek medical help right away if they or a loved one is experiencing delusions.

Bay Biosciences is a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens, and human bio-fluid collections.

Samples available include cancer (tumor) tissue, cancer serum, cancer plasma, cancer, peripheral blood mononuclear cells (PBMC). and human tissue samples from most other therapeutic areas and diseases.

Bay Biosciences maintains and manages its own biorepository, the human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and from normal healthy donors available in all formats and types.

Our biobank procures and stores fully consented, deidentified and institutional review boards (IRB) approved human tissue samples and matched controls.

All our human tissue collections, human specimens and human bio-fluids are provided with detailed, samples associated patient’s clinical data.

This critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers, and genetic information.

Patient’s data is extremely valuable for researchers and is used to help identify new effective treatments (drug discovery & development) in oncology, and other therapeutic areas and diseases.

Bay Biosciences banks wide variety of human tissue samples and biological samples, including cryogenically preserved at – 80°C.

Including fresh frozen tissue samples, tumor tissue samples, formalin-fixed paraffin-embedded (FFPE), tissue slides, with matching human bio-fluids, whole blood and blood-derived products such as serum, plasma and PBMC.

Bay Biosciences is a global leader in collecting and providing human tissue samples according to the specified requirements and customized, tailor-made collection protocols.

Please contact us anytime to discuss your special research projects and customized human tissue sample requirements.

Types of Biospecimens

Bay Biosciences provides human tissue samples (human specimens) from diseased and normal healthy donors which includes:

• Peripheral whole-blood
• Amniotic fluid
• Bronchoalveolar lavage fluid (BAL)
• Sputum
• Pleural effusion
• Cerebrospinal fluid (CSF)
• Serum (sera)
• Plasma
• Peripheral blood mononuclear cells (PBMC)
• Saliva
• Buffy coat
• Urine
• Stool samples
• Aqueous humor
• Vitreous humor
• Kidney stones (renal calculi)
• Other bodily fluids from most diseases including cancer.

We can also procure most human bio-specimens, special collections and requests for human samples that are difficult to find. All our human tissue samples are procured through IRB-approved clinical protocols and procedures.

In addition to the standard processing protocols, Bay Biosciences can also provide human plasma, serum, and PBMC bio-fluid samples using custom processing protocols; you buy donor-specific collections in higher volumes and specified sample aliquots from us.

Bay Biosciences also provides human samples from normal healthy donors; volunteers, for controls and clinical research, contact us Now.

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