Bay Biosciences high quality clinical grade fresh frozen serum, plasma, peripheral blood mononuclear cells (PBMC) biofluid samples derived from patients whole blood, from patients diagnosed with Dementia.

Moreover, detailed clinical data and pathology annotations associated with the dementia patients biofluid samples is provided to a valued pharmaceutical customer for drug discovery and research.

Dementia Overview

Dementia is an overall term for diseases and conditions that decline memory, language, problem-solving, and other thinking skills; consequently, it affects a person’s ability to perform everyday activities.

For instance, memory loss is an example. Specifically, Alzheimer’s is the most common cause of dementia.

Furthermore, dementia is not a single disease; rather, it’s an overall term, similar to heart disease, that covers a wide range of specific medical conditions, including Alzheimer’s disease.

Additionally, abnormal brain changes cause disorders grouped under the general term “dementia.” These changes, in turn, trigger a decline in thinking skills, also known as cognitive abilities, which is severe enough to impair daily life and independent function.

Moreover, they also affect behavior, feelings, and relationships. According to the WHO, around 50 million people have dementia; furthermore, nearly 10 million new cases emerge every year worldwide.

Dementia Signs and Symptoms

Dementia symptoms vary depending on the cause; consequently, different types of dementia can affect people differently. Moreover, everyone will experience symptoms in their own way.

Early common signs and symptoms of dementia include, for instance:

  • Problems with short-term memory, particularly remembering recent events.
  • Additionally, there is difficulty communicating or finding words.
  • Furthermore, mood changes, along with rapid mood swings, are often observed.
  • Increasing confusion and disorientation may also occur.
  • In addition, individuals may face difficulty reasoning or problem-solving.
  • Similarly, there can be difficulty with coordination and motor functions.
  • Moreover, problems with visual and spatial abilities can arise.
  • As a result, reduced concentration is frequently noted.
  • Likewise, personality or behavior changes can manifest.
  • Moreover, apathy and withdrawal or depression may develop.
  • Consequently, there may be a loss of ability to perform everyday tasks.
  • Additionally, individuals may find themselves being confused about time and place.
  • Finally, delirium, where one is unsure of their whereabouts, may also occur.

Causes of Dementia

Dementia isn’t a disease, instead, it’s a neurocognitive disorder or a group of symptoms caused by other conditions.

Dementia occurs when the parts of the brain used for learning, memory, decision making, and language are damaged or diseased.

Following are some of the conditions causing Dementia:

Types of Dementia

Dementia can be split into the following two groups based on which part of the brain is affected. Some types of dementia can affect both parts of the brain.

  • Cortical dementias happen because of problems in the cerebral cortex, the outer layer of the brain. They play a critical role in memory and language. Patients with these types of dementia usually have severe memory loss and can’t remember words or understand language. Alzheimer’s disease
     and Creutzfeldt-Jakob disease are two forms of cortical dementia.
  • Subcortical dementias happen because of problems in the parts of the brain beneath the cortex. Patients with subcortical dementias tend to show changes in their speed of thinking and ability to start activities. Usually, people with subcortical dementia don’t have forgetfulness and language problems. Parkinson’s disease, Huntington’s disease, and HIV can cause these types of dementia.

Stages of Dementia

Usually dementia goes through the following stages, depending on the area of the brain that’s affected:

Stage-1 No impairment: Patients with dementia at this stage will show no symptoms, but tests may reveal a problem.

Stage-2 Very mild decline: Slight changes in normal behavior may be noticed, but the dementia patient will still be independent.

Stage-3 Mild decline: At this point more changes are noticed in the dementia patients thinking and reasoning. They may have trouble making plans, and they may repeat themselves a lot. They may also have a hard time remembering recent events.

Stage-4 Moderate decline: Dementia patients will have more problems with making plans and remembering recent events. They may have a hard time with traveling and handling money by themselves.

Stage-5 Moderately severe decline: Dementia patients may not remember their phone number or their grandchildren’s names. They may be confused about the time of day or day of the week. At this point, they’ll need assistance with some basic day-to-day functions, such as picking out clothes to wear.

Stage- 6 Severe decline: At this stage dementia patients will  begin to forget the name of their spouse. They’ll need help going to the restroom and eating. You may also see changes in their personality and emotions.

Stage-7 Very severe decline: Dementia patients at this stage can no longer speak their thoughts. They can’t walk and will spend most of their time in bed.

Biospecimens

biospecimens

Bay Biosciences is a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens, and human bio-fluid collections.

Human biospecimens are available including cancer (tumor) tissue, cancer serum, cancer plasma, cancer peripheral blood mononuclear cells (PBMC). and human tissue samples from most other therapeutic areas and diseases.

Bay Biosciences maintains and manages its own biorepository, the human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and from normal healthy donors for controls, available in all formats and types.

In fact, our biobank procures and stores fully consented, de-identified and institutional review boards (IRB) approved human tissue samples, human biofluids such as serum samples, plasma samples from various diseases and matched controls.

Also, all our human tissue collections, human biospecimens and human biofluids are provided with detailed, samples associated patient’s clinical data.

In fact, this critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers, and genetic information.

Additionally, researchers find the patient’s data associated with the human biospecimens extremely valuable and use it to help identify new effective treatments (drug discovery & development) in oncology, as well as in other therapeutic areas and diseases.

Bay Biosciences banks wide variety of human tissue samples and human biological samples, including fresh frozen human biospecimens cryogenically preserved at – 80°C.

For example fresh frozen tissue samples, tumor tissue samples, formalin-fixed paraffin-embedded (FFPE), tissue slides, with matching human bio-fluids, whole blood and blood-derived products such as human serum, human plasma and human PBMCs.

Bay Biosciences is a global leader in collecting and providing human tissue samples according to the specified requirements and customized, tailor-made collection protocols.

Please contact us anytime to discuss your special research projects and customized human tissue sample requirements.

Types of Biospecimens

Bay Biosciences provides human tissue samples (human specimens) and human biofluids from diseased and normal healthy donors which includes:

Moreover, we can also procure most human biospecimens and human biofluids, special collections and requests for human samples that are difficult to find. All our human tissue samples and human biofluids are procured through IRB-approved clinical protocols and procedures.

In addition to the standard processing protocols, Bay Biosciences can also provide human biofluids such as  human plasma, human serum, and human PBMCs bio-fluid samples using custom processing protocols; you buy donor-specific collections in higher volumes and specified sample aliquots from us.

Bay Biosciences also provides human biospecimens from normal healthy donors; volunteers, for controls and clinical research, Contact us Now.