Demyelination Polyneuropathy-CIDP Samples

Bay Biosciences provides high-quality, matched fresh frozen sera (serum),  plasma, and peripheral blood mononuclear cells (PBMC) bio-fluids from patients diagnosed with chronic inflammatory demyelinating polyneuropathy (CIDP).

Moreover, the sera (serum), plasma and PBMC bio-fluids are processed from CIDP patient’s peripheral whole-blood using customized collection and processing protocols.

In addition, the matched bio-fluids are collected from unique patients with chronic inflammatory demyelinating polyneuropathy (CIDP) and are provided to a valued pharmaceutical customer for research, development and drug discovery.

Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) Overview

Chronic inflammatory demyelinating polyneuropathy (CIDP) is a rare type of autoimmune neurological disorder that causes nerve swelling or inflammation. This inflammation destroys the protective coating that is wrapped around nerves and fibers. CIDP is also known as Chronic Relapsing Polyneuropathy (CRP) or Chronic Inflammatory Demyelinating Polyradiculoneuropathy because it involves the nerve roots.  In an autoimmune disease, the body attacks its own tissues. In Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) disease the body attacks the myelin sheaths.  Myelin are the fatty coverings on the fibers that insulate and protect the nerves. CIDP leads to symptoms such as tingling sensations in the feet and hands, as well as loss of muscle strength.

Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is a type of acquired immune-mediated inflammatory disorder. It is not contagious, but it’s chronic, which means  that it is a long term disease. Therefore patients are likely to live with symptoms and complications of the disorder for the remainder of their life. CIDP, like the other inflammatory disorders that are similar to it, affects the peripheral nervous system. This includes the nerves outside the brain and spinal cord.

 

CIDP vs Guillain-Barre Syndrome (GBS)

Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is closely related
to Guillain-Barre Syndrome (GBS). Both diseases are nerve problems, and both cause symptoms such as weakness and numbness. But GBS usually comes on days or weeks after a person has an illness, such as a stomach bug. CIDP is not linked to illness. With GBS, once treated, most people recover fairly quickly. CIDP on the other hand tends to be a longer-term problem. In rare cases, people who don’t recover from GBS may develop CIDP.

CIDP vs Multiple Sclerosis (MS) Disease

Just like CIDP, Multiple Sclerosis (MS) destroys the myelin coating around nerves, MS can also be progressive. The disease has a gradual progression that makes symptoms worse over time. Some patients may experience periods of stability followed by periods of relapse.

Unlike CIDP, patients with multiple sclerosis (MS) disease develop plaques on their brain and spinal cord. These plaques prevent their nerves from properly transmitting signals. From their brain through the central nervous system and to the rest of their body. Over time, multiple sclerosis (MS) may even begin attacking the nerves themselves. Symptoms of MS typically show up on one side of the body at a time, not in a symmetrical pattern. The affected area and the severity of symptoms depends greatly on which nerves multiple sclerosis (MS) disease attacks.

Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) Signs and Symptoms

Typical early symptoms of chronic inflammatory demyelinating polyneuropathy (CIDP) are tingling feeling. Sort of electrified vibration or paresthesia or numbness in the extremities. Frequent leg cramps (usually at night time), loss of reflexes in the knees, muscle fasciculations. Moreover, vibration feelings, loss of balance, general muscle cramping and nerve pain. CIDP patients also show symptoms such as loss of sensation (numbness), abnormal sensation (tingling and pain). In addition, loss of reflexes, and weakness (difficulty walking, foot drop). 

Signs and Symptoms of chronic demyelinating polyneuropathy (CIDP) disease include:

  • Slowed Nerve Response- As the myelin is destroyed and lost, the electrical impulses between the brain and nerves will slow or get lost altogether. Initially, the damage is usually minor and  difficult to notice, however over the period of time, the slow response will become quite noticeable.
  • Symmetrical Symptoms- Most patients with CIDP will experience identical symptoms on both sides of their body. Instead of experiencing tingling in just one hand, they are more likely experience tingling in both hands at the same time.
  • Sensory Changes-Tingling, burning, and numbness may develop, CIDP patients may also notice changes to their senses, including loss of taste, decreased sensitivity to touch, and more.
  • Loss of Reflexes-Muscles may not respond as quickly as they once did, and CIDP patients may notice slight muscle weakness.
  • Slow Development of Symptoms Over the Long Term- Symptoms of CIDP may increase slowly over the course of several months or even years. The slow progression may not be detectable at first. Some patients will live with the symptoms for a long period of time before a diagnosis is finally made.

Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) Causes

Chronic inflammatory demyelinating polyneuropathy (CIDP) or polyradiculoneuropathy is considered an autoimmune disorder destroying myelin, the protective covering of the nerves. Researchers are not clear what causes CIDP, but they do know it’s the result of an abnormal immune response which causes inflammation of nerves and nerve roots. The body’s immune system perceives myelin as foreign and attacks it. The swelling can destroy the protective covering around nerves, known as myelin. That can hurt nerve fibers and slow the nerves ability to send signals, which causes the weakness, Pain, Fatigue and numbness. The immune system overreacts to a normal, healthy part of the body. It treats the myelin like invading bacteria or viruses, and destroys it, and for this reason, CIDP is classified as an autoimmune disease.

The body’s immune system, which normally protects itself, perceives myelin as foreign and attacks it. Myelin is an important part of the peripheral nervous system. It wraps around the nerve axon (the long, wire-like part of a nerve cell) much like insulation around an electrical wire. The nerves extend from the spinal cord to the rest of the body, stimulating muscle contraction and transmitting sensory information back to the nervous system from receptors in the skin and joints. This insulation (myelin) allows electrical impulses to efficiently travel along the nerve axon. When myelin is damaged or removed, these electrical impulses are slowed or lost, and messages transmitted from the brain are disrupted and may never make it to their final destination. What causes this process is not yet clear.

Types of Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)

There are several types of immune-mediated neuropathies. Usually CIDP is a symmetrical motor and sensory progressive neuropathy affecting proximal and distal muscles with loss of deep tendon reflexes.

Chronic inflammatory demyelinating polyneuropathy (CIDP) with subtypes:

  • Classical CIDP-Typical CIDP is a symmetrical motor and sensory progressive neuropathy affecting proximal and distal muscles with loss of deep tendon reflexes.
  • Multifocal Motor Neuropathy is a pure motor disorder in which there is asymmetric weakness in the distribution of individual nerves that can be confirmed by diagnostic nerve conduction results.
  • Sensory CIDP-Pure sensory CIDP presents with sensory loss, pain, and poor balance with abnormal gait or walking. There is no weakness but frequently motor nerve conduction studies are abnormal in addition to sensory conduction studies.
  • Multifocal acquired demyelinating sensory and motor neuropathy also known as Lewis-Sumner Syndrome is a sensory-motor disorder in which there is sensory loss and weakness in the distribution of individual nerves. Diagnostic nerve conduction studies confirm the focal nerve involvement.
  • Pure motor CIDP presents with weakness and loss of reflexes without sensory loss.

There are other several other less common CIDP variants.

Biospecimens

Bay Biosciences is, indeed a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens, and human bio-fluid collections.

Specifically, aamples available include cancer (tumor) tissue, cancer serum, cancer plasma, cancer, peripheral blood mononuclear cells (PBMC) and human tissue samples from most other therapeutic areas and diseases.

Moreover, Bay Biosciences maintains and manages its own biorepository, the human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and from normal healthy donors available in all formats and types.

In fact, our biobank procures and stores fully consented, de-identified and institutional review boards (IRB) approved human tissue samples and matched controls.

Additionally, all our human tissue collections, human specimens and human bio-fluids are provided with detailed, samples associated patient’s clinical data.

In particular, critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers, and genetic information.

Moreover, researchers find patient’s data extremely valuable and use it to help identify new effective treatments (drug discovery & development) in oncology, and other therapeutic areas and diseases.

Specifically, Bay Biosciences banks wide variety of human tissue samples and biological samples, including cryogenically preserved at – 80°C.

For example fresh frozen tissue samples, tumor tissue samples, formalin-fixed paraffin-embedded (FFPE), tissue slides, with matching human bio-fluids, whole blood and blood-derived products such as serum, plasma and PBMC.

Furthermore, Bay Biosciences is a global leader in collecting and providing human tissue samples according to the specified requirements and customized, tailor-made collection protocols.

Therefore, please contact us anytime to discuss your special research projects and customized human tissue sample requirements.

Types of Biospecimens

Bay Biosciences provides human tissue samples (human specimens) from diseased and normal healthy donors which includes:

  • Firstly, Peripheral whole-blood
  • Secondly, Amniotic fluid
  • Third, Bronchoalveolar lavage fluid (BAL)
  • Moreover, Sputum
  • Furthermore, Pleural effusion
  • Next, Cerebrospinal fluid (CSF)
  • Also, Serum (sera)
  • Likewise, Plasma
  • In addition, Peripheral blood mononuclear cells (PBMC)
  • For example, Saliva
  • Also, Buffy coat
  • Moreover, Urine
  • Furthermore, stool samples
  • Next, Aqueous humor
  • Likewise, Vitreous humor
  • Lastly, Kidney stones (renal calculi)
  • Finally, Other bodily fluids from most diseases including cancer.

Moreover, we can also procure most human bio-specimens, furthermore; we offer special collections and requests for human samples that are difficult to find. All our human tissue samples are procured through IRB-approved clinical protocols and procedures.

In addition to the standard processing protocols, Bay Biosciences can also provide human plasma, serum, and PBMC bio-fluid samples using custom processing protocols. Additionally you buy donor-specific collections in higher volumes and specified sample aliquots from us.

Furthermore, Bay Biosciences also provides human samples from normal healthy donors; volunteers, for controls and clinical research, contact us Now.

 

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