Bay Biosciences provides fresh frozen tissue samples, sera (serum), plasma and peripheral blood mononuclear cells (PBMC) biofluid samples from patients diagnosed with drug resistant lung disease.

Moreover, the biofluid samples are processed using customized collection and processing protocols for research, development and drug discovery.

Lung disease among patients who don’t respond to conventional therapies (antibacterial medications) is called Drug-resistant respiratory disease or lung disease. In addition,Respiratory Disease is the term for diseases of the respiratory system.

Specifically, these include diseases of the lung, pleural cavity, bronchial tubes, trachea, upper respiratory tract. Additionally, as well as the nerves and muscles of breathing. Moreover, respiratory diseases range from mild and self-limiting conditions. Such as the common cold, to life-threatening conditions such as bacterial pneumonia or pulmonary embolism.

Furthermore, respiratory infections caused by multi-drug resistant bacteria are often associated with a greater likelihood of inappropriate antimicrobial therapy. Consequently, resulting in poor clinical outcomes.

Since the 1940s, antibiotics have been used to treat people with infectious diseases caused by bacteria. These medications greatly reduce illness and death from conditions such as tuberculosis and pneumonia. However, certain antibiotics have been used so widely and for so long that some bacteria that cause disease have become resistant to them. Consequently, making these treatments less effective.

Viruses cause most upper respiratory tract infections (URTIs), such as the common cold and flu, antibiotics do not work against these viruses. If people overuse antibiotics or use them incorrectly, the bacteria might become resistant. This means that the antibiotic becomes less effective against that type of bacterium, as the bacterium has been able to improve its defenses.

Types of Antibiotics

There are different types of antibiotic, which work in one of two ways:

  • A bactericidal antibiotic, such as penicillin, kills the bacteria. These drugs usually interfere with either the formation of the bacterial cell wall or its cell contents.
  • A bacteriostatic stops bacteria from multiplying.

Side Effects

Antibiotics commonly cause the following side effects:

  • Diarrhea
  • Nausea
  • Vomiting
  • Allergic reactions
  • Rash
  • Upset stomach
  • Prolonged use of certain antibiotics can cause fungal infections of the mouth, digestive tract, and vagina

How it Works?

Antibiotic resistance or antimicrobials resistance occurs when the medication loses its ability to kill bacteria. As a result, the organisms continue to grow and cause infections, even in the presence of the antibiotic. Some bacteria are naturally resistant to certain types of antibiotics, but most become resistant through a natural genetic mutation or by acquiring resistance genes from other bacteria. When bacteria mate, they transfer their resistance traits. Because bacteria can acquire many resistance traits over time, they can become resistant to different types of antibiotics. 

Microbes

Microbes or Superbugs that cause respiratory lung infections are posing an increasingly ominous threat. They have dire clinical outcomes, with mortality rates reaching as high as 80 per cent for some infections. Furthermore, they have begun to spread from hospitals to the community at large.

These infections greatly worsen the impacts of these conditions and are usually treated with a course of antibiotics. However, the bacteria’s protective biofilm shields them from the antibiotic. Consequently, making it less effective, which can lead to persistent, recurring and hard to treat infections.

Non-Typeable Haemophilius Influenza (NTHi)

The bacteria non-typeable Haemophilus influenza (NTHi) is a major cause of lung infections in patients with chronic lung diseases like cystic fibrosis, primary ciliary dyskinesia (PCD) and chronic obstructive pulmonary disease (COPD).

In the past 20 years, a steady but constant increase has occurred in invasive NTHi worldwide, with perinatal infants, young children, and elderly people most at risk. Individuals with underlying comorbidities are most susceptible and infection is associated with high mortality. β-lactamase production is the predominant mechanism of resistance.

However, the emergence and spread of β-lactamase-negative ampicillin-resistant strains in many regions of the world is of substantial concern, potentially necessitating changes to antibiotic treatment guidelines for community-acquired.

These infections greatly worsen the impacts of these conditions and are usually treated with a course of antibiotics. However, the bacteria’s protective biofilm shields them from the antibiotic, making it less effective, which can lead to persistent, recurring and hard to treat infections of the upper and lower respiratory tract and potentially increasing morbidity associated with invasive NTHi.

These infections greatly worsen the impacts of these conditions and are usually treated with a course of antibiotics. However, the bacteria’s protective biofilm shields them from the antibiotic, making it less effective, which can lead to persistent, recurring and hard to treat infections.

Drug-resistant Bacteria

As more antibiotics are rendered ineffective by drug-resistant bacteria, and as bacteria grow resistant to conventional antibiotics, research is being done and alternatives are being investigated, including antibodies, probiotics, bacteriophages, and antimicrobial peptides currently in developing phase and some undergoing clinical trials. Advancements within biotechnology, genetic engineering, and synthetic chemistry have opened up new avenues towards the search for therapies that can substitute for antibiotics.

Biospecimens

biospecimens

Bay Biosciences is a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens, and human bio-fluid collections.

Moreover, human biospecimens are available including tumor tissue, serum, plasma and PBMC samples from most other therapeutic areas.

Furthermore, Bay Biosciences maintains and manages its own biorepository, the human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and likewise normal healthy donors for controls. Additionally, available in all formats and types.

In fact, our biobank procures and stores fully consented, de-identified and institutional review boards (IRB) approved human tissue samples, human biofluids such as serum samples, plasma samples from various diseases and matched controls.

Also, all our human tissue collections, human biospecimens and human biofluids are provided with detailed, samples associated patient’s clinical data.

In fact, this critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers, and genetic information.

Additionally, researchers find the patient’s data associated with the human biospecimens extremely valuable and use it to help identify new effective treatments (drug discovery & development) in oncology, as well as in other therapeutic areas and diseases.

Bay Biosciences banks wide variety of human tissue samples and human biological samples, including fresh frozen human biospecimens cryogenically preserved at – 80°C.

For example fresh frozen tissue samples, tumor tissue samples, formalin-fixed paraffin-embedded (FFPE), tissue slides, with matching human bio-fluids, whole blood and blood-derived products such as human serum, human plasma and human PBMCs.

Bay Biosciences is a global leader in collecting and providing human tissue samples according to the specified requirements and customized, tailor-made collection protocols.

Please contact us anytime to discuss your special research projects and customized human tissue sample requirements.

Types of Biospecimens

Bay Biosciences provides human tissue samples (human specimens) and human biofluids from diseased and normal healthy donors which includes:

Moreover, we can also procure most human biospecimens and human biofluids, special collections and requests for human samples that are difficult to find. All our human tissue samples and human biofluids are procured through IRB-approved clinical protocols and procedures.

In addition to the standard processing protocols, Bay Biosciences can also provide human biofluids such as  human plasma, human serum, and human PBMCs bio-fluid samples using custom processing protocols; you buy donor-specific collections in higher volumes and specified sample aliquots from us.

Bay Biosciences also provides human biospecimens from normal healthy donors; volunteers, for controls and clinical research, Contact us Now.