Bay Biosciences provides high quality, clinical grade fully characterized fresh frozen tissue samples, sera (serum), plasma and peripheral blood mononuclear cells (PBMC) biofluid samples from patients diagnosed with Drug Resistant Lung Disease, using customized collection and processing protocols for research, development and drug discovery.
Lung disease caused by bacteria among patients who don’t respond to conventional therapies (antibacterial medications) is called Drug-resistant (Antibiotic Resistance) respiratory disease or lung disease. Respiratory Disease is the term for diseases of the respiratory system. These include diseases of the lung, pleural cavity, bronchial tubes, trachea, upper respiratory tract and of the nerves and muscles of breathing. Respiratory diseases range from mild and self-limiting such as the common cold to life-threatening such as bacterial pneumonia or pulmonary embolism. Respiratory infections caused by multi-drug resistant bacteria are associated with a greater likelihood of inappropriate antimicrobial therapy and poor clinical outcome.
Since the 1940s, antibiotics have been used to treat people with infectious diseases caused by bacteria. These medications greatly reduce illness and death from conditions such as tuberculosis and pneumonia. However, certain antibiotics have been used so widely and for so long that some bacteria that cause disease have become resistant to them, making these treatments less effective.
Viruses cause most upper respiratory tract infections (URTIs), such as the common cold and flu, antibiotics do not work against these viruses. If people overuse antibiotics or use them incorrectly, the bacteria might become resistant. This means that the antibiotic becomes less effective against that type of bacterium, as the bacterium has been able to improve its defenses.
There are different types of antibiotic, which work in one of two ways:
- A bactericidal antibiotic, such as penicillin, kills the bacteria. These drugs usually interfere with either the formation of the bacterial cell wall or its cell contents.
- A bacteriostatic stops bacteria from multiplying.
Antibiotics commonly cause the following side effects:
- Diarrhea
- Nausea
- Vomiting
- Allergic reactions
- Rash
- Upset stomach
- Prolonged use of certain antibiotics can cause fungal infections of the mouth, digestive tract, and vagina
Antibiotic resistance or Antimicrobials resistance occurs when the medication loses its ability to kill bacteria. As a result, the organisms continue to grow and cause infection, even in the presence of the antibiotic. Some bacteria are naturally resistant to certain types of antibiotics, but most become resistant through a natural genetic mutation or by acquiring resistance genes from other bacteria. When bacteria mate, they transfer their resistance traits. Because bacteria can acquire many resistance traits over time, they can become resistant to different types of antibiotics.
Microbes or Superbugs that cause respiratory lung infections are posing an increasingly ominous threat. They have dire clinical outcomes, with mortality rates reaching as high as 80 per cent for some infections. Furthermore, they have begun to spread from hospitals to the community at large.
These infections greatly worsen the impacts of these conditions and are usually treated with a course of antibiotics. However, the bacteria’s protective biofilm shields them from the antibiotic, making it less effective, which can lead to persistent, recurring and hard to treat infections.
The bacteria non-typeable Haemophilus influenza (NTHi) is a major cause of lung infections in patients with chronic lung diseases like cystic fibrosis, primary ciliary dyskinesia (PCD) and chronic obstructive pulmonary disease (COPD).
In the past 20 years, a steady but constant increase has occurred in invasive NTHi worldwide, with perinatal infants, young children, and elderly people most at risk. Individuals with underlying comorbidities are most susceptible and infection is associated with high mortality. β-lactamase production is the predominant mechanism of resistance. However, the emergence and spread of β-lactamase-negative ampicillin-resistant strains in many regions of the world is of substantial concern, potentially necessitating changes to antibiotic treatment guidelines for community-acquired These infections greatly worsen the impacts of these conditions and are usually treated with a course of antibiotics. However, the bacteria’s protective biofilm shields them from the antibiotic, making it less effective, which can lead to persistent, recurring and hard to treat infections of the upper and lower respiratory tract and potentially increasing morbidity associated with invasive NTHi. These infections greatly worsen the impacts of these conditions and are usually treated with a course of antibiotics. However, the bacteria’s protective biofilm shields them from the antibiotic, making it less effective, which can lead to persistent, recurring and hard to treat infections.
As more antibiotics are rendered ineffective by drug-resistant bacteria, and as bacteria grow resistant to conventional antibiotics, research is being done and alternatives are being investigated, including antibodies, probiotics, bacteriophages, and antimicrobial peptides currently in developing phase and some undergoing clinical trials. Advancements within biotechnology, genetic engineering, and synthetic chemistry have opened up new avenues towards the search for therapies that can substitute for antibiotics.
Bay Biosciences is a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens and human bio-fluid collections from cancer (tumor) tissue, cancer sera (serum), cancer plasma, cancer PBMC and human tissue samples from most other therapeutic areas and diseases.
Bay Biosciences maintains and manages it’s own bio-repository, human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and from normal healthy donors available in all formats and types. Our biobank procures and stores fully consented, deidentified and institutional review boards (IRB) approved human tissue samples and matched controls.
All our human human tissue collections, human specimens and human bio-fluids are provided with detailed samples associated patient’s clinical data. This critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers and genetic information. Patient’s data is extremely valuable for researchers and is used to help identify new effective treatments (drug discovery & development) in oncology, other therapeutic areas and diseases. This clinical information is critical to demonstrate their impact, monitor the safety of medicines, testing & diagnostics, and generate new knowledge about the causes of disease and illness.
Bay Biosciences banks wide variety of human tissue samples and biological samples including cryogenically preserved -80°C, fresh, fresh frozen tissue samples, tumor tissue samples, FFPE’s, tissue slides, with matching human bio-fluids, whole blood and blood derived products such as serum, plasma and PBMC’s.
Bay Biosciences is a global leader in collecting and providing human tissue samples according to the researchers specified requirements and customized, tailor made collection protocols. Please contact us anytime to discuss your special research projects and customized human tissue sample requirements.
Bay Biosciences provides human tissue samples (human specimens) from diseased and normal healthy donors; including peripheral whole-blood, amniotic fluid, bronchoalveolar lavage fluid (BAL), sputum, pleural effusion, cerebrospinal fluid (CSF), serum (sera), plasma, peripheral blood mononuclear cells (PBMC’s), saliva, Buffy coat, urine, stool samples, aqueous humor, vitreous humor, kidney stones, renal calculi, nephrolithiasis, urolithiasis and other bodily fluids from most diseases including cancer. We can also procure most human bio-specimens and can do special collections and requests of human samples that are difficult to find. All our human tissue samples are procured through IRB approved clinical protocols and procedures.
In addition to the standard processing protocols Bay Biosciences can also provide human plasma, serum, PBMC bio-fluid samples using custom processing protocols, you can buy donor specific sample collections in higher volumes and specified sample aliquoting from us. Bay Biosciences also provides human samples from normal healthy donors, volunteers, for controls and clinical research, contact us Now.
日本のお客様は、ベイバイオサイエンスジャパンBay Biosciences Japanまたはhttp://baybiosciences-jp.com/contact/までご連絡ください。