Ewing Sarcoma FFPE Tissue Samples for Research

Bay Biosciences provides high quality, clinical grade, formalin fixed paraffin embedded (FFPE) tissue samples for research, with matched K2EDTA plasma, sera (serum) and peripheral blood mononuclear cells (PBMC), bio-fluid samples from Ewing sarcoma patients.

The Ewing sarcoma FFPE Tissue Samples for cancer research and the matched K2EDTA plasma, sera (serum) and PBMC bio-fluid specimens are processed from Ewing sarcoma patient’s peripheral whole-blood using customized collection and processing protocols.

Ewing Sarcoma Overview

Ewing sarcoma is a form of bone cancer that usually affects children and adolescents.

In fact, this type of cancer can be very aggressive, but the cells tend to respond well to radiation therapy. Ideally, doctors will diagnose the cancer before it has spread.

According to the National Library of Medicine, an estimated 250 children in the United States receive a diagnosis of Ewing sarcoma each year.

Also, Ewing sarcoma is one of a group of cancers known collectively as the Ewing sarcoma family of tumors.

However, despite the fact that Ewing sarcoma is a rare form of bone cancer, it is highly malignant and commonly occurs in children between the ages of 10 and 15 years and young adults. 

What is Ewing’s Sarcoma?

Ewing sarcoma is a rare type of cancer that usually starts in the bone, typically in the pelvis, chest wall, or legs, and occurs mostly in children and teenagers.

Although, Dr. James Ewing first described Ewing sarcoma in 1921. Accordingly, he identified cancer cells that looked different than the cells in osteosarcoma, another type of bone tumor.

Therefore, doctors may also refer to this cancer type as the Ewing family of tumors. Because, these tumors have distinct cells that usually respond well to radiation treatments.

Hence, this rare cancer type accounts for just 1.5% of all childhood cancers and is the second most common bone cancer type in childhood, after osteosarcoma.

Ewing Sarcoma Causes

Although researchers are unsure why some people develop Ewing sarcoma, they have identified mutations in certain genes in the tumor cells that cause this cancer.

So these include the EWSR1 gene on chromosome 22 and the FLI1 gene on chromosome 11.

Consequently, these genetic mutations occur spontaneously during a person’s lifetime. However, the individual does not inherit them from a family member.

Also, there are no known risk factors for Ewing sarcoma that make one person more likely than another to develop this cancer.

Ewing Sarcoma Symptoms

Ewing sarcoma can cause the following symptoms:

  • A bone that breaks easily or without a clear cause
  • Fever
  • A lump under the skin that is usually soft and warm to the touch
  • Pain in the affected area, such as the arms, back, chest, legs, or pelvis
  • Swelling in the affected area

In fact, an estimated 87% of Ewing sarcomas are sarcoma of the bone. However, the other types form in the soft tissues, such as cartilage, that surround the bones.

Also, Ewing sarcoma can spread to other areas of the body. Therefore, doctors call this process metastasis.

Hence, areas that the cancer can spread to include other bones, bone marrow, and the lungs.

Additionally, doctors categorize Ewing sarcoma as one of three types according to its extent:

  • Localized Ewing sarcoma: The cancer has not spread to other body parts but may have spread to other nearby lymph nodes.
  • Metastatic Ewing sarcoma: The cancer has spread to other parts of the body, such as the lungs, bone marrow, or other bones.
  • Recurring Ewing sarcoma: A person has had Ewing sarcoma before, and it has come back.

Ewing Sarcoma Diagnosis

In fact, before diagnosing Ewing sarcoma, a doctor will take a person’s full medical history and ask them what symptoms they are having, when they noticed them, and what makes them better or worse. Moreover, they will also perform a thorough physical exam, focusing on the area of concern.

Also, a doctor will usually recommend an imaging study to view the bone or bones. Therefore, these tests include the following:

However, if it looks as though a tumor may be present, a doctor will perform a biopsy, which involves taking a sample of bone tissue. Therefore, they will send this tissue to a laboratory, where a specialist called a pathologist will check it for the presence of cancerous cells.

Furthermore, a doctor may also order blood tests, a bone marrow biopsy, and other scans when necessary. As a result, these tests can help determine whether the cancer has spread to other locations.

Ewing Sarcoma Treatment

A doctor will work with a team of cancer specialists and surgeons to recommend and implement particular treatments.

Possible treatments for Ewing sarcoma include:

  • Chemotherapy: Chemotherapy uses medications to kill off multiplying cancer cells. Therefore, it is often the first treatment for Ewing sarcoma. For this reason, a patient will usually receive chemotherapy for 6 to 12 months.
  • Radiation: Radiation therapy involves killing cancerous cells with high energy radiation treatments. Consequently, sometimes, doctors prescribe radiation therapy to shrink a tumor or keep it from spreading.
  • Surgery: In certain cases, a doctor will recommend surgically removing the tumor. In summary, if a doctor has to take out a lot of bone, they may recommend replacing it with a bone graft or artificial bone.
  • Stem cells: Doctors may use stem cell transplants from a donor’s bone marrow to encourage healthy bone cell growth.

Also, doctors may use a combination of treatments depending on how far the cancer has spread and a person’s overall health.

However, research into new treatments for Ewing sarcoma is ongoing. Therefore, some doctors may inform their patients about clinical trials, which help test new treatments.

Ewings Sarcoma Complications

Possible complications of Ewing sarcoma include the following:

  • Pleural effusion, which is the buildup of fluid in the lung tissue layers
  • Problems with breathing
  • Weakness or paralysis of muscles

Consequently, if Ewing sarcoma has spread to other areas of the body, it can be life threatening. For this reason, it is vital for a doctor to evaluate any symptoms as quickly as possible.

Outlook of Ewing Sarcoma

According to the American Academy of Orthopaedic Surgeons, an estimated two-thirds of people in whom cancer has not spread to other areas of the body survive at least 5 years after their diagnosis.

Patients who are more likely to have positive outcomes include those who have:

  • Cancer that responds well to chemotherapy
  • A tumor that occurs in the arms or legs, as the pelvis is usually harder to treat
  • Cancer that has not spread
  • A tumor that a surgeon can completely remove

However, the likelihood of successful treatment is different for every individual, so people should speak to a doctor about their or their child’s expected outlook.

Summary

Ewing sarcoma is a rare type of cancer that mostly affects young people.

When doctors detect it early enough, the condition usually responds well to treatment.

Anyone who notices signs or symptoms of Ewing sarcoma, such as a bone that breaks for no apparent reason or a painful lump or swelling, should speak to a doctor.

Contact Bay Biosciences for your requirements of Ewing Sarcoma FFPE Tissue Samples for Research.

biospecimens

Biospecimens

Bay Biosciences is a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens, and human bio-fluid collections.

Human biospecimens are available including cancer (tumor) tissue, cancer serum, cancer plasma, cancer peripheral blood mononuclear cells (PBMC). and human tissue samples from most other therapeutic areas and diseases.

Bay Biosciences maintains and manages its own biorepository, the human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and from normal healthy donors for controls, available in all formats and types.

In fact, our biobank procures and stores fully consented, de-identified and institutional review boards (IRB) approved human tissue samples, human biofluids such as serum samples, plasma samples from various diseases and matched controls.

Also, all our human tissue collections, human biospecimens and human biofluids are provided with detailed, samples associated patient’s clinical data.

In fact, this critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers, and genetic information.

Additionally, patient’s data associated with the human biospecimens is extremely valuable for researchers and is used to help identify new effective treatments (drug discovery & development) in oncology, and other therapeutic areas and diseases.

Bay Biosciences banks wide variety of human tissue samples and human biological samples, including fresh frozen human biospecimens cryogenically preserved at – 80°C.

For example fresh frozen tissue samples, tumor tissue samples, formalin-fixed paraffin-embedded (FFPE), tissue slides, with matching human bio-fluids, whole blood and blood-derived products such as human serum, human plasma and human PBMCs.

Bay Biosciences is a global leader in collecting and providing human tissue samples according to the specified requirements and customized, tailor-made collection protocols.

Please contact us anytime to discuss your special research projects and customized human tissue sample requirements.

Types of Biospecimens

Bay Biosciences provides human tissue samples (human specimens) and human biofluids from diseased and normal healthy donors which includes:

Moreover, we can also procure most human biospecimens and human biofluids, special collections and requests for human samples that are difficult to find. All our human tissue samples and human biofluids are procured through IRB-approved clinical protocols and procedures.

In addition to the standard processing protocols, Bay Biosciences can also provide human biofluids such as  human plasma, human serum, and human PBMCs bio-fluid samples using custom processing protocols; you buy donor-specific collections in higher volumes and specified sample aliquots from us.

Bay Biosciences also provides human biospecimens from normal healthy donors; volunteers, for controls and clinical research, Contact us Now.