Bay Biosciences provides Ewing sarcoma tumor tissue samples FFPE Blocks from unique pediatric patients.

Moreover, detailed clinical data and pathology annotations including patient’s corresponding diagnostic test values associated with the FFPE samples are provided to a valued pharmaceutical customer for research.

Ewing Sarcoma Overview

A very rare type of highly aggressive cancer (tumor), Ewing’s sarcoma grows in the bones or the soft tissue around the bones, such as cartilage or the nerves. Specifically, it primarily occurs in children and young adults, often appearing during the teen years.

In fact, people from the ages of 10 to 20 are usually affected, and there is a high rate of being cured. Moreover, any bone can develop Ewing’s sarcoma, but it usually affects the long bones, such as the thighbone (femur), shinbone (tibia), and upper arm bone (humerus).

Additionally, the pelvis, legs, ribs, arms, or spine often also have affected bones. Furthermore, occasionally, the muscles and soft tissues begin to host the tumor; this is referred to as extraosseous Ewing’s sarcoma.

Ultimately, Ewing’s sarcoma has the potential to spread (metastasize) to other body parts, including the lungs, bones, bone marrow, and other soft tissues.

Types of Ewing Sarcoma

Three types of Ewing sarcoma exist:

  • First, Ewing sarcoma of bone is the most common type.
  • In addition, Extraosseous Ewing tumor (EOE) affects the soft tissues surrounding the bones, including muscles, tendons, and ligaments.
  • Lastly, Peripheral primitive neuroectodermal tumor (PPNET) can start in either bone or soft tissue.

Signs and Symptoms of Ewing Sarcoma

 The common signs and symptoms of Ewing sarcoma include:

Causes of Ewing’s Sarcoma

The causes of Ewing sarcoma remain unknown. However, it is known by doctors that Ewing sarcoma begins when changes develop in a cell’s DNA. Specifically, a cell’s DNA contains the instructions that direct cellular actions. Consequently, these changes instruct the cell to multiply rapidly and to survive when healthy cells would typically die.

As a result, this leads to the formation of a mass (tumor) of abnormal cells that can invade and damage healthy body tissue. Furthermore, the abnormal cells have the ability to break away and spread (metastasize) throughout the body. In Ewing sarcoma, the DNA changes most often affect the EWSR1 gene.

Genetic Testing

If Ewing sarcoma is suspected by the doctor, then testing may be conducted on the cancer cells to look for changes in this gene. It is known that most cancers arise from specific types of tissue or organs. For example, breast cells give rise to breast cancer. Nevertheless, the exact type of cell where Ewing’s sarcoma begins is not known.

Moreover, it is understood that the cancer forms when changes occur in a cell’s chromosomes. In Ewing’s sarcoma cells, consequently, a mismatch exists in the genetic material of chromosomes 11 and 22.

Parents do not inherit this genetic abnormality to their child; instead, chromosomal changes occur after the child is born. Furthermore, the reason for the occurrence of this abnormality remains unclear.

Moreover, no risk factors have been identified by doctors that would make one child more susceptible than another. Consequently, the development of the tumor is not a result of dietary, social, or behavioral habits.

Risk factors for Ewing Sarcoma

A risk factor refers to anything that can elevate an individual’s likelihood of developing cancer or other diseases. Following are the risk factors for Ewing sarcoma:

  • Firstly, your age: This disease can be contracted by anyone, but it predominantly affects individuals between the ages of 10 and 20.
  • Secondly, your sex: Ewing sarcoma is somewhat more prevalent in males compared to females.
  • Finally, your race: The likelihood of the disease affecting individuals is greater among those who are white (Hispanic or non-Hispanic) than among those who are Asian American or Black.

Biospecimens

biospecimens

Bay Biosciences is a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens, and human bio-fluid collections.

Human biospecimens are available including cancer (tumor) tissue, cancer serum, cancer plasma, cancer peripheral blood mononuclear cells (PBMC). and human tissue samples from most other therapeutic areas and diseases.

Bay Biosciences maintains and manages its own biorepository, the human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and from normal healthy donors for controls, available in all formats and types.

In fact, our biobank procures and stores fully consented, de-identified and institutional review boards (IRB) approved human tissue samples, human biofluids such as serum samples, plasma samples from various diseases and matched controls.

Also, all our human tissue collections, human biospecimens and human biofluids are provided with detailed, samples associated patient’s clinical data.

In fact, this critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers, and genetic information.

Additionally, researchers find the patient’s data associated with the human biospecimens extremely valuable and use it to help identify new effective treatments (drug discovery & development) in oncology, as well as in other therapeutic areas and diseases.

Bay Biosciences banks wide variety of human tissue samples and human biological samples, including fresh frozen human biospecimens cryogenically preserved at – 80°C.

For example fresh frozen tissue samples, tumor tissue samples, formalin-fixed paraffin-embedded (FFPE), tissue slides, with matching human bio-fluids, whole blood and blood-derived products such as human serum, human plasma and human PBMCs.

Bay Biosciences is a global leader in collecting and providing human tissue samples according to the specified requirements and customized, tailor-made collection protocols.

Please contact us anytime to discuss your special research projects and customized human tissue sample requirements.

Types of Biospecimens

Bay Biosciences provides human tissue samples (human specimens) and human biofluids from diseased and normal healthy donors which includes:

Moreover, we can also procure most human biospecimens and human biofluids, special collections and requests for human samples that are difficult to find. All our human tissue samples and human biofluids are procured through IRB-approved clinical protocols and procedures.

In addition to the standard processing protocols, Bay Biosciences can also provide human biofluids such as  human plasma, human serum, and human PBMCs bio-fluid samples using custom processing protocols; you buy donor-specific collections in higher volumes and specified sample aliquots from us.

Bay Biosciences also provides human biospecimens from normal healthy donors; volunteers, for controls and clinical research, Contact us Now.