Granulomatosis Polyangiitis (GPA) Samples

Bay Biosciences provides high-quality, matched fresh frozen sera (serum),  plasma, and peripheral blood mononuclear cells (PBMC) bio-fluids from patients diagnosed with granulomatosis with polyangiitis (GPA) disease.

Moreover, the sera (serum), plasma and PBMC bio-fluids are processed from granulomatosis with polyangiitis (GPA)patient’s peripheral whole-blood using customized collection and processing protocols.

In addition, the matched bio-fluids are collected from unique patients with granulomatosis with polyangiitis (GPA) and are provided to a valued pharmaceutical customer for research, development and drug discovery.

 

Granulomatosis with Polyangiitis (GPA) Disease Overview

In fact, granulomatosis with polyangiitis (GPA), formerly known as Wegener’s granulomatosis (WG), is a very rare autoimmune. Specifically, it causes the inflammation of blood vessels in different parts of the body.

Moreover, granulomatosis with polyangiitis (GPA) is a long-term systemic disorder. It involves the formation of granulomas and inflammation of blood vessels (vasculitis).

In particular, it is a form of vasculitis that affects small- and medium-sized vessels in many organs. However, most commonly affects the upper respiratory tract, lungs, and kidneys. Furthermore, the signs and symptoms of GPA are highly varied. And reflect on which organs the affected blood vessels supply.

For example, typical signs and symptoms include, nosebleeds, stuffy nose, and crustiness of nasal secretions.

As well as inflammation of the uveal layer of the eye. Additionally, damage to the heart, lungs, and kidneys can be fatal. Consequently, the cause of GPA is unknown. However, researchers have found that genetics play a role in GPA, although the risk of inheritance appears to be low.

Furthermore, granulomatosis with polyangiitis (GPA) disease treatment depends on the severity of the disease. In general, healthcare providers typically treat severe disease with a combination of immunosuppressive medications. Moreover, a high-dose corticosteroids in order to control the symptoms of the disease. And keep the disease under control. In addition, doctors also use plasma exchange in severe cases with damage to the lungs, kidneys, or intestines.

Granulomatosis with Polyangiitis (GPA) Disease Causes

The cause of Granulomatosis with Polyangiitis (GPA) is unknown. Although microbes, such as bacteria and viruses, as well as genetics have been implicated in its pathogenesis. 

As with all autoimmune disorders, Granulomatosis with Polyangiitis (GPA) is characterized by an immune system gone awry. For reasons unknown, the body will mistakenly identify normal tissue in blood vessels as foreign. In order to contain the perceived threat, immune cells will surround the cells and form a hardened nodule known as a granuloma.

The formation of granulomas can lead to the development of chronic inflammation. In the affected blood vessels a condition known as vasculitis. Moreover, over time, this can structurally weaken the vessels and cause them to burst.

Usually at the site of the granulomatous growths. It can also cause the blood vessels to harden and narrow, cutting the blood supply to key parts of the body.

Granulomatosis with Polyangiitis (GPA) mainly affects small- to medium-sized blood vessels. While the respiratory tract, lungs, and kidneys are the main targets of attacks. However, GPA can also cause damage to the skin, joints, and nervous system. The heart, brain, and gastrointestinal tract are rarely affected. GPA affects men and women equally, primarily between the ages of 40 and 60. 

 

Signs and Symptoms of Granulomatosis with Polyangiitis (GPA) Disease

Initial signs and symptoms of Granulomatosis with Polyangiitis (GPA) disease are highly variable, and diagnosis can be severely delayed due to the nonspecific nature of the symptoms. In general, irritation and inflammation of the nose are the first signs in most patients. Involvement of the upper respiratory tract, such as the nose and sinuses, is seen in nearly all people with Granulomatosis with Polyangiitis (GPA) disease. Typical signs and symptoms of nose or sinus involvement include crusting around the nose, stuffiness, nosebleeds, runny nose and saddle-nose deformity due to a hole in the septum of the nose. Inflammation of the outer layers of the eye, Scleritis, Episcleritis and Conjunctivitis are the most common signs of GPA in the eye; involvement of the eyes is common and occurs in slightly more than half of the patients with the GPA disease.

Signs and symptoms of Granulomatosis with Polyangiitis (GPA) as the disease progresses, other, more serious symptoms may develop, including:

The generalized nature of these symptoms can often make the diagnosis difficult. It is not uncommon, for example, for Granulomatosis with Polyangiitis (GPA) disease to be misdiagnosed and treated as a respiratory infection. It only when doctors can find no evidence of a viral or bacterial cause that further investigations may be ordered, particularly when there is evidence of vasculitis.

Systemic Symptoms

As a systemic disease, Granulomatosis with Polyangiitis (GPA) can cause injury one or several organ systems at once. While the location of symptoms can vary, the underlying cause (vasculitis) usually guides the doctor toward an autoimmune diagnosis if multiple organs are involved.

Systemic symptoms of Granulomatosis with Polyangiitis (GPA) disease may include:

  • The collapse of the nasal bridge due to a perforated septum (also known as the “saddle nose” deformity similar to that seen with long-term cocaine use)
  • Tooth loss due to underlying bone destruction
  • Sensorineural hearing loss caused by damage to the inner ear
  • The development of granulomatous growths in parts of the eye
  • Voice changes due to the narrowing of the trachea
  • Blood in urine (hematuria)
  • The rapid loss of kidney function leading to kidney failure
  • A cough with bloody phlegm due to the formation of granulomatous lesions and cavities in the lungs
  • Arthritis (often initially diagnosed as rheumatoid arthritis)
  • The development of red or purple patches on the skin (purpura)
  • Numbness, tingling, or burning sensations caused by nerve damage (neuropathy)

Granulomatosis with Polyangiitis (GPA) Disease Diagnosis

The diagnosis of Granulomatosis with Polyangiitis (GPA) disease is typically only made after several, unrelated symptoms go unexplained for a long period of time. While there are blood tests available to identify the specific autoantibodies associated with the disease, the presence (or lack) of antibodies is not enough to confirm (or reject) a diagnosis.

Instead, diagnoses are made based on the combination of symptoms, lab tests, X-rays, and the results of a physical examination. Other tools may be needed to support a diagnosis, including a biopsy of the affected tissue.

A lung biopsy is usually the best place to start even if there are no respiratory symptoms. Biopsies of the upper respiratory tract, by contrast, tend to be the least helpful since 50 percent will show no signs of granulomas or tissue damage. Similarly, a chest X-ray or CT scan can often reveal lung abnormalities in persons with otherwise normal lung function. Together, the combination of tests and symptoms may be enough to support a Granulomatosis with Polyangiitis (GPA) disease diagnosis.

Detailed clinical data, ANCA positive test, biopsy elevated biomarker levels, genetic and metabolic information, histopathological findings, annotations associated with the Granulomatosis with Polyangiitis (GPA) disease patient’s specimens is provided to a valued customer for research, development and drug discovery. The researcher processes the Granulomatosis with Polyangiitis (GPA) disease sera (serum), plasma, and PBMC biofluid samples from patients’ peripheral whole-blood using customized collection and processing protocols.

Biospecimens

Bay Biosciences is, indeed a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens, and human bio-fluid collections.

Specifically, aamples available include cancer (tumor) tissue, cancer serum, cancer plasma, cancer, peripheral blood mononuclear cells (PBMC) and human tissue samples from most other therapeutic areas and diseases.

Moreover, Bay Biosciences maintains and manages its own biorepository, the human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and from normal healthy donors available in all formats and types.

In fact, our biobank procures and stores fully consented, de-identified and institutional review boards (IRB) approved human tissue samples and matched controls.

Additionally, all our human tissue collections, human specimens and human bio-fluids are provided with detailed, samples associated patient’s clinical data.

In particular, critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers, and genetic information.

Moreover, researchers find patient’s data extremely valuable and use it to help identify new effective treatments (drug discovery & development) in oncology, and other therapeutic areas and diseases.

Specifically, Bay Biosciences banks wide variety of human tissue samples and biological samples, including cryogenically preserved at – 80°C.

For example fresh frozen tissue samples, tumor tissue samples, formalin-fixed paraffin-embedded (FFPE), tissue slides, with matching human bio-fluids, whole blood and blood-derived products such as serum, plasma and PBMC.

Furthermore, Bay Biosciences is a global leader in collecting and providing human tissue samples according to the specified requirements and customized, tailor-made collection protocols.

Therefore, please contact us anytime to discuss your special research projects and customized human tissue sample requirements.

Types of Biospecimens

Bay Biosciences provides human tissue samples (human specimens) from diseased and normal healthy donors which includes:

  • Firstly, Peripheral whole-blood
  • Secondly, Amniotic fluid
  • Third, Bronchoalveolar lavage fluid (BAL)
  • Moreover, Sputum
  • Furthermore, Pleural effusion
  • Next, Cerebrospinal fluid (CSF)
  • Also, Serum (sera)
  • Likewise, Plasma
  • In addition, Peripheral blood mononuclear cells (PBMC)
  • For example, Saliva
  • Also, Buffy coat
  • Moreover, Urine
  • Furthermore, stool samples
  • Next, Aqueous humor
  • Likewise, Vitreous humor
  • Lastly, Kidney stones (renal calculi)
  • Finally, Other bodily fluids from most diseases including cancer.

Moreover, we can also procure most human bio-specimens, furthermore; we offer special collections and requests for human samples that are difficult to find. All our human tissue samples are procured through IRB-approved clinical protocols and procedures.

In addition to the standard processing protocols, Bay Biosciences can also provide human plasma, serum, and PBMC bio-fluid samples using custom processing protocols. Additionally you buy donor-specific collections in higher volumes and specified sample aliquots from us.

Furthermore, Bay Biosciences also provides human samples from normal healthy donors; volunteers, for controls and clinical research, contact us Now.

 

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