Hidradenitis Suppurativa (HS) Samples for Research

Bay Biosciences provides high-quality, matched fresh frozen sera (serum),  plasma, and peripheral blood mononuclear cells (PBMC) bio-fluids from patients diagnosed with hidradenitis suppurativa disease.

Moreover, the sera (serum), plasma and PBMC bio-fluids are processed from hidradenitis suppurativa disease patient’s peripheral whole-blood using customized collection and processing protocols.

In addition, the matched bio-fluids are collected from unique patients with hidradenitis suppurativa disease and are provided to a valued pharmaceutical customer for research, development and drug discovery.

Hidradenitis Suppurativa Overview

Hidradenitis suppurativa is a chronic inflammatory skin disease that affects apocrine gland-bearing skin in the axillae, groin, and under the breasts. Furthermore, hidradenitis suppurativa also goes by the name acne inversa. It presents persistent or recurrent boil-like nodules and abscesses that culminate in a purulent discharge, sinuses, and scarring.

Moreover, hidradenitis suppurativa has a significant psychological impact, and many patients suffer from anxiety, depression, and impairment of body image. Additionally, hidradenitis suppurativa tends to start after puberty. Consequently, it can persist for many years and worsen over time, with serious effects on your daily life and emotional well-being.

Prevalence

Notably, hidradenitis suppurativa is most active between the ages of 20 and 40 years, and in women, it can resolve at menopause. Interestingly, it is three times more common in females than in males.

In terms of progression, hidradenitis suppurativa usually starts with a firm pea-sized lump that develops in one place. This will either disappear or rupture and ooze pus after a few hours or days.

Subsequently, new lumps will then often develop in an area nearby. If these are not controlled with medicine, larger lumps may develop and spread. Additionally, narrow channels called sinus tracts also form under the skin that break out on the surface and leak pus. In fact, hidradenitis suppurativa is very painful disease.

The lumps develop on the skin in the following areas:

  • First, around the groin and genitals
  • Second, in the armpits
  • Next, on the bottom and around the anus
  • Finally, below the breasts

The abscesses may also spread to the nape of the neck, waistband and inner thighs. Other isolated areas that have been known to affect include the front or back of the legs, the sides, the back area and the face. Some of the lumps may become infected with bacteria, causing a secondary infection that will need to be treated with antibiotics.

Many people with hidradenitis suppurativa also develop a pilonidal sinus, which is a small hole or “tunnel” in the skin.

Causes of Hidradenitis Suppurativa

Exact cause of hidradenitis suppurativa is unknown, but blocked hair follicles cause the lumps to develop. Smoking and obesity strongly associate with hidradenitis suppurativa, and if you are obese and/or smoke, it will make your symptoms worse.

Hidradenitis suppurativa usually starts around puberty, but it can occur at any age. It’s less common before puberty and after the menopause, which may suggest that the sex hormones play a part. Many people with the condition also have acne and excessive hair growth (hirsutism).

In rare cases, hidradenitis suppurativa may be linked to Crohn’s disease, particularly if it develops around the groin area and the skin near the anus. Crohn’s disease is a long-term condition that causes the lining of the digestive system to become inflamed. Hidradenitis suppurativa runs in families in about a third of all cases. It’s not infectious and is not linked to poor hygiene.

Experts think it could be connected to hormones, inherited genes and immune system problems. Smoking, excess weight and metabolic syndrome also might play a role. Hidradenitis suppurativa is not caused by an infection or being unclean, and it can’t be spread to other people.

Signs and Symptoms of Hidradenitis Suppurativa

Following are the signs and symptoms of Hidradenitis suppurativa, it can affect one spot or multiple areas of the body:

  • Blackheads: Small pitted areas of skin containing blackheads often appearing in pairs or a “double-barreled” pattern  are a common feature of Hidradenitis suppurativa.
  • Painful pea-sized lumps: The condition usually starts with a single, painful lump under the skin that persists for weeks or months. Later more bumps form. They usually appear in areas with hair follicles with many oil and sweat glands, such as the armpits, groin and anal area. They also occur where skin rubs together, such as the inner thighs, breast and buttocks.
  • Tunnels: Over time, tracts connecting the lumps may form under the skin. These wounds heal very slowly, if at all, and can leak pus, which may have an odor.

Some patients with this condition experience only mild symptoms. Excess weight, stress, hormonal changes, heat or humidity may worsen symptoms. In women, the disease severity may lessen after menopause.

Hidradenitis suppurativa is characterized clinically by:

  • Open double-headed comedones
  • Painful firm papules and nodules
  • Pustules, fluctuant pseudocysts, and abscesses
  • Draining sinuses linking inflammatory lesions
  • Hypertrophic and atrophic scars

Complications of Hidradenitis Suppurativa

Following are the complications of hidradenitis suppurativa:

  • Psychological effects and negative impact on quality-of-life
  • Pyogenic granuloma
  • Lymphoedema (female genital)
  • Squamous cell carcinoma (male anogenital)
  • Anemia of chronic disease

Diagnosis of Hidradenitis Suppurativa

The diagnosis of hidradenitis suppurativa requires all three components of the following to be met:

  • Characteristic lesions
  • Typical distribution
  • Presence and recurrence of lesions.

Swabs for bacteriology are typically negative, which is a clue to diagnosis. Extensive investigations are rarely required. Investigations may be indicated to exclude a differential diagnosis, for possible complications, to identify comorbidities, or for planned treatment.

Biospecimens

Bay Biosciences is, indeed a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens, and human bio-fluid collections.

Specifically, aamples available include cancer (tumor) tissue, cancer serum, cancer plasma, cancer, peripheral blood mononuclear cells (PBMC) and human tissue samples from most other therapeutic areas and diseases.

Moreover, Bay Biosciences maintains and manages its own biorepository, the human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and from normal healthy donors available in all formats and types.

In fact, our biobank procures and stores fully consented, de-identified and institutional review boards (IRB) approved human tissue samples and matched controls.

Additionally, all our human tissue collections, human specimens and human bio-fluids are provided with detailed, samples associated patient’s clinical data.

In particular, critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers, and genetic information.

Moreover, researchers find patient’s data extremely valuable and use it to help identify new effective treatments (drug discovery & development) in oncology, and other therapeutic areas and diseases.

Specifically, Bay Biosciences banks wide variety of human tissue samples and biological samples, including cryogenically preserved at – 80°C.

For example fresh frozen tissue samples, tumor tissue samples, formalin-fixed paraffin-embedded (FFPE), tissue slides, with matching human bio-fluids, whole blood and blood-derived products such as serum, plasma and PBMC.

Furthermore, Bay Biosciences is a global leader in collecting and providing human tissue samples according to the specified requirements and customized, tailor-made collection protocols.

Therefore, please contact us anytime to discuss your special research projects and customized human tissue sample requirements.

Types of Biospecimens

Bay Biosciences provides human tissue samples (human specimens) from diseased and normal healthy donors which includes:

  • Firstly, Peripheral whole-blood
  • Secondly, Amniotic fluid
  • Third, Bronchoalveolar lavage fluid (BAL)
  • Moreover, Sputum
  • Furthermore, Pleural effusion
  • Next, Cerebrospinal fluid (CSF)
  • Also, Serum (sera)
  • Likewise, Plasma
  • In addition, Peripheral blood mononuclear cells (PBMC)
  • For example, Saliva
  • Also, Buffy coat
  • Moreover, Urine
  • Furthermore, stool samples
  • Next, Aqueous humor
  • Likewise, Vitreous humor
  • Lastly, Kidney stones (renal calculi)
  • Finally, Other bodily fluids from most diseases including cancer.

Moreover, we can also procure most human bio-specimens, furthermore; we offer special collections and requests for human samples that are difficult to find. All our human tissue samples are procured through IRB-approved clinical protocols and procedures.

In addition to the standard processing protocols, Bay Biosciences can also provide human plasma, serum, and PBMC bio-fluid samples using custom processing protocols. Additionally you buy donor-specific collections in higher volumes and specified sample aliquots from us.

Furthermore, Bay Biosciences also provides human samples from normal healthy donors; volunteers, for controls and clinical research, contact us Now.

 

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