IgA Nephropathy (IgAN) Samples for Research
Bay Biosciences provides high-quality fresh frozen sera (serum), plasma, and peripheral blood mononuclear cells (PBMC) bio-fluid samples for research from patients diagnosed with IgA nephropathy (IgAN).
Moreover, the sera (serum), plasma and PBMC samples are processed from IgA nephropathy (IgAN) patient’s peripheral whole-blood using customized collection and processing protocols for research.
In addition, the matched bio-fluid samples are collected from unique patients with IgA nephropathy (IgAN) and are provided to a valued pharmaceutical customer for research, development and drug discovery.
Uses of IgA Nephropathy (IgAN) Samples for Research
IgA nephropathy (IgAN) samples are foundational to biomedical research, providing direct insight into disease biology at the cellular and structural level.
Pharmaceutical companies rely on IgA nephropathy (IgAN) samples to validate drug targets, assess tissue-specific toxicity, and confirm therapeutic mechanisms before advancing to clinical trials.
IgA Nephropathy (IgAN) Overview
Symptoms of IgA Nephropathy (IgAN)
Initially, IgAN may not cause symptoms, and in some people, symptoms might take 10 years or more to appear.
Sometimes, routine medical tests will discover IgAN by identifying protein or red blood cells in the urine under a microscope.
If symptoms occur, they may include:
- Firstly, urine that is pink or the color of cola (known as gross hematuria or visible hematuria)
- Secondly, urine that is foamy (known as proteinuria)
- Thirdly, visible blood in the urine
- Next, swelling in the ankles, feet, legs, or other areas of the body (known as edema)
- In addition, pain or discomfort beneath the ribs or in the lower back
- Moreover, high blood pressure
- Furthermore, fatigue
- Finally, weakness
Causes and Risk Factors
The exact cause of IgAN is unknown and is the subject of ongoing research. In addition, health experts believe that both genes and the environment may play a role.
For instance, in some people, symptoms may first appear following a respiratory infection, sore throat, or cold.
Moreover, IgAN can occur in anyone, but it is more common in certain groups. These include people who have:
- First, celiac disease
- Second, inflammatory bowel disease (IBD)
- Moreover, a family history of IgAN or IgA vasculitis
- Furthermore, hepatitis
- In addition, cirrhosis
- Likewise, HIV
- Lastly, Asian, White European, or Pacific Island ancestry
Notably, IgAN is also more common in people with penises and those between the ages of 10 and 40.
Complications of IgA Nephropathy (IgAN)
For example, high blood pressure
Also, chronic kidney disease
Moreover, cardiovascular disease
Furthermore, the high amounts of protein that can enter the urine due to IgAN can increase the risk of stroke, heart attack, and heart failure.Likewise, kidney failure
Treatment of IgA Nephropathy (IgAN)
Currently, there is no cure for IgAN. Instead, treatment focuses on symptom management, managing blood pressure, and slowing the progression of kidney disease where possible.
Generally, a kidney specialist, known as a nephrologist, supervises treatment for IgAN.
In addition, medications and lifestyle changes are the typical treatment options.
Medications
In this context, doctors may recommend a variety of medications for the treatment of IgAN, and more are being investigated via clinical trials.
ACE inhibitors or ARBs
Notably, doctors consider angiotensin receptor blockers (ARBs) or angiotensin converting enzyme (ACE) inhibitors the first-line treatment for IgAN. They work by reducing the amount of protein in the urine as well as lowering blood pressure. Thus, this can help slow down the progression of chronic kidney disease due to IgAN.
Moreover, even those who do not have high blood pressure can benefit from these medications as they help slow damage to the kidneys.
Endothelin receptor (type A) antagonists (ERAs)
ERAs are a newer type of medication that helps relax the blood vessels in the kidneys. Consequently, the amount of protein in the urine is reduced, and the process of chronic kidney disease may slow.
SGLT2 inhibitors
Specifically, these drugs work by reducing the amount of protein in the urine, which slows the progression of the disease.
Furthermore, they can also help manage blood sugar levels in those with diabetes. Moreover, people can use them alongside both ACE inhibitors and ARBs.
Corticosteroids
Alternatively, also known as steroids, these medications work by calming the immune system. As a result, this means the immune system produces less of the IgA antibody, and the kidneys are more likely to recover.
Typically, doctors would recommend taking steroids for short periods of time to minimize the risk of side effects such as bone weakening, high blood sugar, and weight gain.
Life-style Changes
A few lifestyle modifications can assist in the management of IgAN and reduce the risk of chronic kidney disease from worsening.
In addition, these lifestyle changes include:
- Firstly, quitting smoking, if applicable (smoking can speed up the progression of kidney disease and increase the risk of kidney failure)
- Moreover, maintaining a moderate weight is essential
- Furthermore, exercising regularly can also contribute positively
- Additionally, limiting sodium intake to less than 2,300 milligrams per day, the equivalent of about 1 teaspoon is recommended.
Summary
IgA nephropathy (IgAN) is an autoimmune kidney disease. Specifically, it is a key contributor to both chronic kidney disease and kidney failure. Although symptoms may not appear for 10 years or more, they may include changes to urine. Consequently, IgAN can cause a variety of complications, including kidney failure and cardiovascular disease. Although there is no cure, approaches to manage the disease include medications and lifestyle modifications.
Biospecimens
Bay Biosciences is, indeed a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens, and human bio-fluid collections.
Specifically, samples available include cancer (tumor) tissue, cancer serum, cancer plasma, cancer, peripheral blood mononuclear cells (PBMC) and human tissue samples from most other therapeutic areas and diseases.
Moreover, Bay Biosciences maintains and manages its own biorepository, the human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and from normal healthy donors available in all formats and types.
In fact, our biobank procures and stores fully consented, de-identified and institutional review boards (IRB) approved human tissue samples and matched controls.
Additionally, all our human tissue collections, human specimens and human bio-fluids are provided with detailed, samples associated patient’s clinical data.
In particular, critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers, and genetic information.
Moreover, researchers find patient’s data extremely valuable and use it to help identify new effective treatments (drug discovery & development) in oncology, and other therapeutic areas and diseases.
Specifically, Bay Biosciences banks wide variety of human tissue samples and biological samples, including cryogenically preserved at – 80°C.
For example fresh frozen tissue samples, tumor tissue samples, formalin-fixed paraffin-embedded (FFPE), tissue slides, with matching human bio-fluids, whole blood and blood-derived products such as serum, plasma and PBMC.
Furthermore, Bay Biosciences is a global leader in collecting and providing human tissue samples according to the specified requirements and customized, tailor-made collection protocols.
Therefore, please contact us anytime to discuss your special research projects and customized human tissue sample requirements.
Types of Biospecimens
Bay Biosciences provides human tissue samples (human specimens) from diseased and normal healthy donors which includes:
- Firstly, Peripheral whole-blood
- Secondly, Amniotic fluid
- Third, Bronchoalveolar lavage fluid (BAL)
- Moreover, Sputum
- Furthermore, Pleural effusion
- Next, Cerebrospinal fluid (CSF)
- Also, Serum (sera)
- Likewise, Plasma
- In addition, Peripheral blood mononuclear cells (PBMC)
- For example, Saliva
- Also, Buffy coat
- Moreover, Urine
- Furthermore, stool samples
- Next, Aqueous humor
- Likewise, Vitreous humor
- Lastly, Kidney stones (renal calculi)
- Finally, Other bodily fluids from most diseases including cancer.
Moreover, we can also procure most human bio-specimens, furthermore; we offer special collections and requests for human samples that are difficult to find. All our human tissue samples are procured through IRB-approved clinical protocols and procedures.
In addition to the standard processing protocols, Bay Biosciences can also provide human plasma, serum, and PBMC bio-fluid samples using custom processing protocols. Additionally, you buy donor-specific collections in higher volumes and specified sample aliquots from us.
Furthermore, Bay Biosciences also provides human samples from normal healthy donors; volunteers, for controls and clinical research, contact us Now.
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