Bay Biosciences provides high quality, clinical grade, matched cryogenically preserved sera (serum), plasma, peripheral blood mononuclear cells (PBMC) biofluid samples from patients diagnosed with Leukemia.
The sera (serum), plasma and PBMC biofluid specimens are processed from leukemia patient’s peripheral whole-blood using customized collection and processing protocols.
The leukemia matched biofluid samples are collected from unique patients diagnosed with leukemia and are provided to a valued pharmaceutical customer for research, diagnostics, discovery and drug development.
Detailed clinical data, leukemia patient’s history, symptoms, complete blood count (CBC), serology, MRI, biopsy tissue, histopathology information, elevated biomarker levels, genetic and metabolic information associated with leukemia specimens is provided to a valued customer for research, development and drug discovery.
The leukemia sera (serum), plasma and peripheral blood mononuclear cells (PBMC) biofluids are processed from patients peripheral whole-blood using customized collection and processing protocols.
Leukemia Overview
Leukemia is a cancer of the blood cells. There are several broad categories of blood cells, including red blood cells (RBCs), white blood cells (WBCs), and platelets. Generally, leukemia refers to cancers of the WBCs.
WBCs are a vital part of the immune system. They protect the body from invasion by bacteria, viruses, and fungi, as well as from abnormal cells and other foreign substances. In leukemia, the WBCs don’t function like normal WBCs. They can also divide too quickly and eventually crowd out normal cells.
White blood cells are mostly produced in the bone marrow, but certain types of WBCs are also made in the lymph nodes, spleen and thymus gland. Once formed, WBCs circulate throughout the body in the blood and lymph (fluid that circulates through the lymphatic system), concentrating in the lymph nodes and spleen.
Types of Leukemia
Leukemia is categorized based on which type of white blood cell is involved, lymphocytes or myeloid cells and whether the illness is developing very quickly (acute disease) or slowly over time (chronic disease).
Lymphocytic leukemias develop from cells that give rise to T lymphocytes (T cells), B lymphocytes (B cells), or natural killer (NK) cells. Each of these cell types has a specialized role in the immune system; some produce antibodies, whereas others directly fight or direct other immune cells to fight infections.
Myeloid leukemias develop from cells that give rise to white blood cells called granulocytes and monocytes. Granulocytes get their name from the enzyme-packed granules they carry inside them. They release these enzymes when encountering invading bacteria or fungi. Monocytes eventually become macrophages, which engulf and destroy bacteria and fungi.
In acute leukemias, which develop rapidly, the malignant cells, called blasts, which are immature and incapable of performing their immune system functions. Chronic leukemias develop in more-mature cells, which can perform some of their duties but not very well. These abnormal cells usually multiply at a slower rate than acute leukemias.
Of the four common types of leukemia in adults, acute myeloid leukemia (AML) and chronic lymphocytic leukemia (CLL) occur most frequently. Other related blood cancers include myeloproliferative neoplasms and systemic mastocytosis.
- Hairy Cell Leukemia (HCL)
Hairy cell leukemia (HCL) is a rare cancer in adults that is usually found during testing for a low blood count. Read more about what doctors at MSK are looking for when they diagnose HCL. - Acute Lymphocytic Leukemia (ALL)
Acute lymphocytic leukemia (ALL) is a rare cancer in adults, but it is the most common form of leukemia in children. Read more about what doctors at MSK are looking for when they diagnose ALL. - Acute Myeloid Leukemia (AML)
Acute myeloid leukemia (AML) is one of the most common leukemias in adults. Learn more about AML and how it’s diagnosed. - Acute Promyelocytic Leukemia (APL)
Acute promyelocytic leukemia (APL) is an aggressive type of acute myeloid leukemia. Learn more about APL and how it’s diagnosed. - Chronic Lymphocytic Leukemia (CLL)
Chronic lymphocytic leukemia (CLL) is the most common chronic leukemia in adults. Therapies for CLL are improving and changing rapidly. Learn about treatments for CLL. - Chronic Myeloid Leukemia (CML)
Learn more about what role chromosomes play in developing chronic myeloid leukemia (CML). - Myeloproliferative Neoplasms (MPN)
See what it is that bone marrow does and how it can lead to the development of disorders known as myeloproliferative neoplasms. - Systemic Mastocytosis
Mastocytosis happens when too many mast cells build up in the body. Read about how this disorder is diagnosed and its relationship to allergies.
Signs and Symptoms of Leukemia
Following are the common signs and symptoms of leukemia:
- Excessive sweating especially at night
- Chronic Fatigue and weakness
- Unintentional weight loss
- Bone pain and tenderness
- Painless, swollen lymph nodes (in the neck and armpits)
- Enlarged liver or spleen
- Red spots on the skin (petechiae)
- Bleeding and bruising easily
- Fever or chills
- Frequent infections
Leukemia can also cause symptoms in organs that have been infiltrated or affected by the cancer cells. For example, if the cancer spreads to the central nervous system, it can cause headaches, nausea and vomiting, confusion, loss of muscle control, and seizures.
Leukemia can also spread to other parts of your body, including:
- The Lungs
- Gastrointestinal Tract (GIT)
- Heart
- Kidneys
- Testes
Bay Biosciences is a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens and human bio-fluid collections from cancer (tumor) tissue, cancer serum, cancer plasma cancer PBMC and human tissue samples from most other therapeutic areas and diseases.
Bay Biosciences maintains and manages it’s own bio-repository, human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and from normal healthy donors available in all formats and types. Our biobank procures and stores fully consented, deidentified and institutional review boards (IRB) approved human tissue samples and matched controls.
All our human human tissue collections, human specimens and human bio-fluids are provided with detailed samples associated patient’s clinical data. This critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers and genetic information.
Patient’s data is extremely valuable for researchers and is used to help identify new effective treatments (drug discovery & development) in oncology, other therapeutic areas and diseases. This clinical information is critical to demonstrate their impact, monitor the safety of medicines, testing & diagnostics, and generate new knowledge about the causes of disease and illness.
Bay Biosciences banks wide variety of human tissue samples and biological samples including cryogenically preserved -80°C, fresh, fresh frozen tissue samples, tumor tissue samples, FFPE’s, tissue slides, with matching human bio-fluids, whole blood and blood derived products such as serum, plasma and PBMC’s.
Bay Biosciences is a global leader in collecting and providing human tissue samples according to the researchers specified requirements and customized, tailor made collection protocols. Please contact us anytime to discuss your special research projects and customized human tissue sample requirements.
Bay Biosciences provides human tissue samples (human specimens) from diseased and normal healthy donors; including peripheral whole-blood, amniotic fluid, bronchoalveolar lavage fluid (BAL), sputum, pleural effusion, cerebrospinal fluid (CSF), serum (sera), plasma, peripheral blood mononuclear cells (PBMC’s), saliva, Buffy coat, urine, stool samples, aqueous humor, vitreous humor, kidney stones, renal calculi, nephrolithiasis, urolithiasis and other bodily fluids from most diseases including cancer.
We can also procure most human bio-specimens and can do special collections and requests of human samples that are difficult to find. All our human tissue samples are procured through IRB approved clinical protocols and procedures.
In addition to the standard processing protocols Bay Biosciences can also provide human plasma, serum, PBMC bio-fluid samples using custom processing protocols, you can buy donor specific sample collections in higher volumes and specified sample aliquoting from us.
Bay Biosciences also provides human samples from normal healthy donors, volunteers, for controls and clinical research, contact us Now.
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