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Bay Biosciences provides high quality, clinical grade, matched cryogenically preserved serum (serum), plasma, peripheral blood mononuclear cells (PBMC) bio-fluid samples from patients diagnosed with Leukemia.

Moreover, the serum, plasma and PBMCs are processed from leukemia patient’s peripheral whole-blood using customized collection and processing protocols.

The leukemia matched biofluid samples are collected from unique patients diagnosed with leukemia and are provided to a valued pharmaceutical customer for research, diagnostics, discovery and drug development.

Detailed clinical data, leukemia patient’s history, symptoms, complete blood count (CBC), serology, MRI, biopsy tissue, histopathology information, elevated biomarker levels, genetic and metabolic information associated with leukemia specimens is provided to a valued customer for research, development and drug discovery.

The leukemia sera (serum), plasma and peripheral blood mononuclear cells (PBMC) biofluids are processed from patients peripheral whole-blood using customized collection and processing protocols.

Leukemia Overview

Leukemia is a cancer of the blood cells. Furthermore, there are several broad categories of blood cells, including red blood cells (RBCs), white blood cells (WBCs), and platelets. Generally, leukemia refers to cancers of the WBCs.

In addition, WBCs are a vital part of the immune system. Specifically, they protect the body from invasion by bacteria, viruses, and fungi, as well as from abnormal cells and other foreign substances. However, in leukemia, the WBCs don’t function like normal WBCs. Moreover, they can also divide too quickly and eventually crowd out normal cells.

Furthermore, white blood cells are mostly produced in the bone marrow, but certain types of WBCs are also made in the lymph nodes, spleen, and thymus gland. Once formed, WBCs circulate throughout the body in the blood and lymph (fluid that circulates through the lymphatic system), concentrating in the lymph nodes and spleen.

Types of Leukemia

Leukemia is categorized based on which type of white blood cell is involved, lymphocytes or myeloid cells, and whether the illness is developing very quickly (acute disease) or slowly over time (chronic disease).

Specifically, lymphocytic leukemias develop from cells that give rise to T lymphocytes (T cells), B lymphocytes (B cells), or natural killer (NK) cells. Furthermore, each of these cell types has a specialized role in the immune system; for example, some produce antibodies, whereas others directly fight or direct other immune cells to fight infections.

On the other hand, myeloid leukemias develop from cells that give rise to white blood cells called granulocytes and monocytes. Notably, granulocytes get their name from the enzyme-packed granules they carry inside them. Consequently, they release these enzymes when encountering invading bacteria or fungi. In addition, monocytes eventually become macrophages, which engulf and destroy bacteria and fungi.

In acute leukemias, which develop rapidly, the malignant cells, called blasts, are immature and incapable of performing their immune system functions. Conversely, chronic leukemias develop in more-mature cells, which can perform some of their duties, albeit not very well. As a result, these abnormal cells usually multiply at a slower rate than acute leukemias.

Common Types

Of the four common types of leukemia in adults, acute myeloid leukemia (AML) and chronic lymphocytic leukemia (CLL) occur most frequently. Other related blood cancers include myeloproliferative neoplasms and systemic mastocytosis.

Signs and Symptoms of Leukemia

Following are the common signs and symptoms of leukemia:

• Firstly, excessive sweating especially at night
• Secondly, chronic fatigue and weakness
• Thirdly, bone pain and tenderness
• Next, painless, swollen lymph nodes (in the neck and armpits)
• Moreover, enlarged liver or spleen
• Furthermore, red spots on the skin (petechiae)
• In addition, bleeding and bruising easily
• Also, fever or chills
• Finally, frequent infections
• Lastly, unexplained Weight Loss

Leukemia can also cause symptoms in organs that have been infiltrated or affected by the cancer cells. For example, if the cancer spreads to the central nervous system, it can cause headaches, nausea and vomiting, confusion, loss of muscle control, and seizures.

Furthermore, leukemia can also spread to other parts of your body, including:

• First, the Lungs
• Second, gastrointestinal tract (GIT)
• Moreover, heart
• Furthermore, kidneys
• Lastly, testes

Bay Biosciences is a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens, and human bio-fluid collections.

Moreover, human biospecimens are available including tumor tissue, serum, plasma and PBMC Samples from most other therapeutic areas.

Furthermore, Bay Biosciences maintains and manages its own biorepository, the human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and likewise normal healthy donors for controls. Additionally, available in all formats and types.

In fact, our biobank procures and stores fully consented, de-identified and institutional review boards (IRB) approved human tissue samples, human biofluids such as serum samples, plasma samples from various diseases and matched controls.

Also, all our human tissue collections, human biospecimens and human biofluids are provided with detailed, samples associated patient’s clinical data.

In fact, this critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers, and genetic information.

Additionally, researchers find the patient’s data associated with the human biospecimens extremely valuable and use it to help identify new effective treatments (drug discovery & development) in oncology, as well as in other therapeutic areas and diseases.

Bay Biosciences banks wide variety of human tissue samples and human biological samples, including fresh frozen human biospecimens cryogenically preserved at – 80°C.

For example fresh frozen tissue samples, tumor tissue samples, formalin-fixed paraffin-embedded (FFPE), tissue slides, with matching human bio-fluids, whole blood and blood-derived products such as human serum, human plasma and human PBMCs.

Bay Biosciences is a global leader in collecting and providing human tissue samples according to the specified requirements and customized, tailor-made collection protocols.

Please contact us anytime to discuss your special research projects and customized human tissue sample requirements.

Types of Biospecimens

Bay Biosciences provides human tissue samples (human specimens) and human biofluids from diseased and normal healthy donors which includes:

• Peripheral whole-blood
• Amniotic fluid
• Bronchoalveolar lavage fluid (BAL)
• Sputum
• Pleural effusion
• Cerebrospinal fluid (CSF)
• Serum (sera)
• Plasma
• Peripheral blood mononuclear cells (PBMC)
• Saliva
• Buffy coat
• Urine
• Stool samples
• Aqueous humor
• Vitreous humor
• Kidney stones (renal calculi)
• Other bodily fluids from most diseases including cancer.

Moreover, we can also procure most human biospecimens and human biofluids, special collections and requests for human samples that are difficult to find. All our human tissue samples and human biofluids are procured through IRB-approved clinical protocols and procedures.

In addition to the standard processing protocols, Bay Biosciences can also provide human biofluids such as  human plasma, human serum, and human PBMCs bio-fluid samples using custom processing protocols. you buy donor-specific collections in higher volumes and specified sample aliquots from us in multiple format and sets.

Bay Biosciences also provides human biospecimens from normal healthy donors; volunteers, for controls and clinical research, Contact us Now.

• 日本のお客様は、ベイバイオサイエンスジャパンBay Biosciences Japanまたはhttp://baybiosciences-jp.com/contact/までご連絡ください。