Bay Biosciences provides high quality, clinical grade, biopsy tissue samples, FFPE tissue blocks with matched cryogenically preserved sera (serum), plasma, peripheral blood mononuclear cells (PBMC) biofluid samples from patients diagnosed with systemic lupus erythematosus (SLE).
The sera (serum), plasma and PBMC biofluid specimens are processed from systemic lupus erythematosus (SLE) patient’s peripheral whole-blood using customized collection and processing protocols.
Biopsy tissue and matched biofluid samples are collected from unique patients diagnosed with systemic lupus erythematosus (SLE) and are provided to a valued pharmaceutical customer for research, diagnostics, discovery and drug development.
Detailed clinical data, patient’s history, symptoms, complete blood count (CBC), serology, MRI, biopsy tissue findings, histopathology information, elevated biomarker levels, genetic and metabolic information associated with systemic lupus erythematosus (SLE) specimens is provided to a valued customer for research, development and drug discovery.
The systemic lupus erythematosus (SLE), sera (serum), plasma and peripheral blood mononuclear cells (PBMC) biofluids are processed from patients peripheral whole-blood using customized collection and processing protocols.
Systemic Lupus Erythematosus (SLE) Overview
Systemic Lupus Erythematosus (SLE) Symptoms can vary and can change over time. Most common symptoms include anemia, blood clotting, severe fatigue, headaches, hair loss, joint pain, swelling, rash on the cheeks and nose. Other symptoms depend on the part of the body the disease is attacking.
Signs and Symptoms of Systemic lupus erythematosus (SLE)
The signs and symptoms of Systemic lupus erythematosus (SLE) can vary from person to person, and may come and go, depending on what part of the body is affected, can be mild, moderate, or severe. Some patients have just a few symptoms, while others have many, can vary and change over time. Diagnosis can be difficult because lupus mimics many other diseases; it requires clinical and serologic criteria.
Following are the common symptoms of Systemic lupus erythematosus (SLE):
- Anemia
- Severe Fatigue
- Fingers turning white or blue and tingling when cold, which is known as Raynaud’s phenomenon
- Joint Pain
- Joint swelling
- Headaches
- A rash on the cheeks and nose, which is called a “butterfly rash”
- Hair Loss
- Fever
- Mouth sores
- Photosensitivity
- Inflammation of the membranes that surround the lungs (Pleuritis)
- Inflammation of the pericardium which is the fibrous sac surrounding the heart (Pericarditis)
- Blood clotting problems
Other symptoms depend on the part of the body the disease is attacking, such as the digestive tract or the skin. Other symptoms can include sun sensitivity, oral ulcers, arthritis, lung problems, heart problems, kidney problems, seizures, psychosis, and blood cell and immunological abnormalities.
Causes of Systemic lupus erythematosus (SLE)
The cause of Systemic lupus erythematosus (SLE) is not clearly known. It’s thought to be the result of a mix of genetic, hormonal and environmental factors. For example, the immune system makes proteins called antibodies that fight infection. In lupus, the body also makes autoantibodies that are similar, but attack the body’s own tissues instead (autoimmune), It is unknown why this happens. There are some factors that probably make this more likely:
- An illness or infection
- Strong sunlight
- Hormonal changes, such as during puberty
- Smoking cigarettes
- Certain medications, this is known as drug-induced lupus, and this usually gets better when patients come off the medication that caused it.
Lupus isn’t directly passed on from a parent to their children, but if you have a close relative with lupus then you may be at increased risk of developing it.
Systemic lupus erythematosus (SLE) is more common in women than men by nearly 10 to 1. It may occur at any age. However, it appears most often in young women between the ages of 15 and 44. In the US, the disease is more common in African Americans, Asian Americans, African Caribbean’s, and Hispanic Americans. Lupus isn’t contagious, so you can’t catch it from anyone else.
Bay Biosciences is a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens and human bio-fluid collections.
We have samples available are cancer (tumor) tissue, cancer serum, cancer plasma cancer PBMC and human tissue samples from most other therapeutic areas and diseases.
Our company Bay Biosciences maintains and manages its own bio-repository, human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and from normal healthy donors available in all formats and types.
Our biobank procures and stores fully consented, deidentified and institutional review boards (IRB) approved human tissue samples and matched controls.
All our human tissue collections, human specimens and human bio-fluids are provided with detailed samples associated patient’s clinical data.
This critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers and genetic information.
Patient’s data is extremely valuable for researchers and is used to help identify new effective treatments (drug discovery & development) in oncology, other therapeutic areas and diseases.
This clinical information is critical to demonstrate their impact, monitor the safety of medicines, testing & diagnostics, and generate new knowledge about the causes of disease and illness.
Bay Biosciences banks wide variety of human tissue samples and biological samples including cryogenically preserved at – 80°C.
Including fresh frozen tissue samples, tumor tissue samples, FFPE’s, tissue slides, with matching human bio-fluids, whole blood and blood derived products such as serum, plasma and PBMC’s.
Bay Biosciences is a global leader in collecting and providing human tissue samples according to the researchers specified requirements and customized, tailor-made collection protocols.
Please contact us anytime to discuss your special research projects and customized human tissue sample requirements.
Bay Biosciences provides human tissue samples (human specimens) from diseased and normal healthy donors which includes:
- Peripheral whole-blood,
- Amniotic fluid
- Bronchoalveolar lavage fluid (BAL)
- Sputum
- Pleural effusion
- Cerebrospinal fluid (CSF)
- Serum (sera)
- Plasma
- Peripheral blood mononuclear cells (PBMC’s)
- Saliva
- Buffy coat
- Urine
- Stool samples
- Aqueous humor
- Vitreous humor
- Kidney stones (renal calculi)
- Other bodily fluids from most diseases including cancer.
We can also procure most human bio-specimens and can-do special collections and requests of human samples that are difficult to find. All our human tissue samples are procured through IRB approved clinical protocols and procedures.
In addition to the standard processing protocols Bay Biosciences can also provide human plasma, serum, PBMC bio-fluid samples using custom processing protocols, you can buy donor specific sample collections in higher volumes and specified sample aliquots from us.
Bay Biosciences also provides human samples from normal healthy donors, volunteers, for controls and clinical research, contact us Now.
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