Lynch Syndrome Specimens for Research

Biosciences provides high-quality, matched fresh frozen sera (serum),  plasma, and peripheral blood mononuclear cells (PBMC) bio-fluids from patients diagnosed with Lynch syndrome.

Moreover, the sera (serum), plasma and PBMC bio-fluids are processed from Lynch syndrome patient’s peripheral whole-blood using customized collection and processing protocols.

In addition, the matched bio-fluids are collected from unique patients with Lynch syndrome and are provided to a valued pharmaceutical customer for research, development and drug discovery.

Lynch Syndrome Overview

Lynch syndrome is an inherited condition that increases a person’s risk of several types of cancer. Specifically, they used to know it as “hereditary non-polyposis colorectal cancer (HNPCC)”.  Moreover, a mutation affecting one of a number of genes causes it.

Consequently, Lynch syndrome increases the risk of developing colon cancer, endometrial cancer, and several other cancers.

In addition, a number of inherited cancer syndromes can increase the risk of colon cancer or endometrial cancer. Notably, in which Lynch syndrome is the most common. This is because the increased risk for these cancers is due to inherited mutations that impair DNA mismatch repair.

Furthermore, Lynch syndrome is a type of cancer syndrome that is caused by mutations in tumor suppressor genes. These are genes that protect the cell from turning cancerous. Additionally, other genes that may be affected are DNA repair genes. Moreover, oncogenes, and genes involved in the production of blood vessels (angiogenesis).

Specifically, there are four genes that have been linked to Lynch syndrome, called MLHL, MSH2, MSH6, and PMS2. Interestingly, mutations in another gene called EPCAM can cause Lynch syndrome by affecting MSH2, the gene next to it; however, this is very rare.

 DNA Mismatch

The MLH1, MSH2, MSH6, and PMS2 genes produce DNA mismatch repair proteins. Consequently, these proteins stop cancer from developing by helping to repair any DNA damage that always happens when cells divide.

All cells have two copies of a gene, one from each parent. However, a gene mutation, or spelling error, in one of these genes means that a cell only has one good copy. As a result, if that cell suffers a mutation in the one good copy, it can no longer repair mismatches, and thus, the DNA errors aren’t repaired.

Consequently, the abnormal cells can continue to divide with these mistakes, which can then lead to uncontrolled cell growth. This is why, ultimately, the risk of cancer is increased. This is a bit like a spelling error in an instruction manual; therefore, the instructions don’t make sense, so whatever you’re building won’t work properly. In this case, the mismatch repair genes don’t work.

Moreover, families that have Lynch syndrome usually have more instances of colon cancer or endometrial cancer than would typically be expected. Furthermore, Lynch syndrome also causes cancers to occur at an earlier age than they might in the general population.

 

Lynch Syndrome Symptoms

Patients with Lynch syndrome may experience:

  • Colon cancer developing at a younger age, especially before age 50
  • A family history of colon cancer that occurs at a young age
  • A family history of cancer cancer that affects the uterus (endometrial cancer)
  • A family history of other cancer related cancers, including ovarian cancer, kidney cancer, stomach cancer, small intestine cancer, liver cancer, sweat gland cancer (sebaceous carcinoma) and other cancers.

Lynch Syndrome Causes

Lynch syndrome runs in families in an autosomal dominant inheritance pattern. This means that if one parent carries a gene mutation for Lynch syndrome, there’s a 50 percent chance that mutation will be passed on to each child. The risk of Lynch syndrome is the same whether the gene mutation carrier is the mother or father or whether the child is a son or daughter.

Gene mutations causing cancer

The genes affected in Lynch syndrome are responsible for correcting changes in the genetic code (mismatch repair genes). Your genes contain DNA, which carries instructions for every chemical process in your body. As your cells grow and divide, they make copies of their DNA and it’s not uncommon for some minor mistakes to occur. Normal cells have mechanisms to recognize mistakes and repair them. But the cells of patients who inherit one of the abnormal genes associated with Lynch syndrome lack the ability to repair these minor mistakes. An accumulation of these mistakes leads to increasing genetic damage within cells and eventually can cause the cells to become cancerous.

Lynch Syndrome Risk Factors

Lynch syndrome is also linked to an increased risk of developing other cancers including:

Biospecimens

Bay Biosciences is, indeed a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens, and human bio-fluid collections.

Specifically, aamples available include cancer (tumor) tissue, cancer serum, cancer plasma, cancer, peripheral blood mononuclear cells (PBMC) and human tissue samples from most other therapeutic areas and diseases.

Moreover, Bay Biosciences maintains and manages its own biorepository, the human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and from normal healthy donors available in all formats and types.

In fact, our biobank procures and stores fully consented, de-identified and institutional review boards (IRB) approved human tissue samples and matched controls.

Additionally, all our human tissue collections, human specimens and human bio-fluids are provided with detailed, samples associated patient’s clinical data.

In particular, critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers, and genetic information.

Moreover, researchers find patient’s data extremely valuable and use it to help identify new effective treatments (drug discovery & development) in oncology, and other therapeutic areas and diseases.

Specifically, Bay Biosciences banks wide variety of human tissue samples and biological samples, including cryogenically preserved at – 80°C.

For example fresh frozen tissue samples, tumor tissue samples, formalin-fixed paraffin-embedded (FFPE), tissue slides, with matching human bio-fluids, whole blood and blood-derived products such as serum, plasma and PBMC.

Furthermore, Bay Biosciences is a global leader in collecting and providing human tissue samples according to the specified requirements and customized, tailor-made collection protocols.

Therefore, please contact us anytime to discuss your special research projects and customized human tissue sample requirements.

Types of Biospecimens

Bay Biosciences provides human tissue samples (human specimens) from diseased and normal healthy donors which includes:

  • Firstly, Peripheral whole-blood
  • Secondly, Amniotic fluid
  • Third, Bronchoalveolar lavage fluid (BAL)
  • Moreover, Sputum
  • Furthermore, Pleural effusion
  • Next, Cerebrospinal fluid (CSF)
  • Also, Serum (sera)
  • Likewise, Plasma
  • In addition, Peripheral blood mononuclear cells (PBMC)
  • For example, Saliva
  • Also, Buffy coat
  • Moreover, Urine
  • Furthermore, stool samples
  • Next, Aqueous humor
  • Likewise, Vitreous humor
  • Lastly, Kidney stones (renal calculi)
  • Finally, Other bodily fluids from most diseases including cancer.

Moreover, we can also procure most human bio-specimens, furthermore; we offer special collections and requests for human samples that are difficult to find. All our human tissue samples are procured through IRB-approved clinical protocols and procedures.

In addition to the standard processing protocols, Bay Biosciences can also provide human plasma, serum, and PBMC bio-fluid samples using custom processing protocols. Additionally you buy donor-specific collections in higher volumes and specified sample aliquots from us.

Furthermore, Bay Biosciences also provides human samples from normal healthy donors; volunteers, for controls and clinical research, contact us Now.

 

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