Bay Biosciences provides high quality, clinical grade bio-samples, cryogenically preserved tumor tissue samples, FFPE blocks, sera (serum), plasma and peripheral blood mononuclear cells (PBMC) biofluid specimens from patients diagnosed with Malignant Mesothelioma.
The sera (serum), plasma and PBMC biofluid samples are processed from patient’s peripheral whole-blood using customized collection and processing protocols. The Malignant Mesothelioma bio-specimens are collected from unique patients diagnosed with Malignant Mesothelioma and are provided to a valued pharmaceutical customer for translational research, genomics, proteomics and biomarker research, drug discovery and development.
Malignant Mesothelioma Overview
Mesothelioma is a type of cancer that develops from the thin layer of tissue that covers majority of the internal organs known as the mesothelium. Mesothelioma is an aggressive and deadly form of cancer. Mesothelioma treatments are available, but for many patients with mesothelioma, a cure is not possible. Mesothelioma most often affects the tissue that surrounds the lungs (pleura), this type is called pleural mesothelioma. Other, rarer types of mesothelioma affect tissue in the abdomen (peritoneal mesothelioma), around the heart and around the testicles.
The most common area affected is the lining of the lungs and chest wall. Less commonly the lining of the abdomen and rarely the sac surrounding the heart or the sac surrounding the testis may be affected. Signs and symptoms of mesothelioma may include shortness of breath due to fluid around the lungs, a swollen abdomen, chest wall pain, cough, fatigue, and weight loss. These symptoms typically come on slowly.
Mesothelioma Symptoms
Signs and symptoms of mesothelioma vary depending on where the cancer occurs.
Pleural Mesothelioma, which affects the tissue that surrounds the lungs, causes signs and symptoms that may include:
- Chest Pain
- Painful Cough
- Shortness of breath
- Unusual lumps of tissue under the skin on the chest
- Unexplained weight loss
Peritoneal mesothelioma, which occurs in tissue in the abdomen, causes signs and symptoms that may include:
Other Forms of Mesothelioma
Signs and symptoms of other types of mesothelioma are unclear, since these forms of the disease are very rare.
Pericardial mesothelioma, which affects tissue that surrounds the heart, can cause signs and symptoms such as breathing difficulty, shortness of breath and chest pains.
Mesothelioma of tunica vaginalis, which affects tissue surrounding the testicles, may be first detected as swelling or a mass on a testicle.
Mesothelioma Causes
In general, cancer begins when a series of changes (mutations) happens in a cell’s DNA. The DNA contains the instructions that tell a cell what to do. The mutations tell the cell to grow and multiply out of control. The abnormal cells accumulate and form a tumor. It is not clear what causes the initial genetic mutations that lead to Mesothelioma, though researchers have identified factors that may increase the risk. It’s likely that cancer form because of an interaction between many factors, such as inherited conditions, environment, health conditions and lifestyle choices.
Mesothelioma Risk Factors
Asbestos exposure: The primary risk factor for Mesothelioma
Most mesotheliomas are thought to be related to asbestos exposure. Asbestos is a mineral that’s found naturally in the environment. Asbestos fibers are strong and resistant to heat, making them useful in a wide variety of applications, such as in insulation, brakes, shingles, flooring and many other products. When asbestos is broken up, such as during the mining process or when removing asbestos insulation, dust may be created. If the dust is inhaled or swallowed, the microscopic asbestos fibers will settle in the lungs or in the stomach, where they can cause irritation that may lead to mesothelioma. Exactly how this happens is not understood. It can take 20 to 60 years or more for mesothelioma to develop after asbestos exposure.
Most people with asbestos exposure never develop mesothelioma. This indicates that other factors may be involved in determining whether someone gets mesothelioma. For instance, you could inherit a predisposition to cancer or some other condition could increase your risk.
Factors that may increase the risk of mesothelioma include:
- Personal history of asbestos exposure: If a person has been directly exposed to asbestos fibers at work or at home, the risk of mesothelioma is greatly increased.
- Living with someone who works with asbestos: People who are exposed to asbestos may carry the fibers home on their skin and clothing. Exposure to these stray fibers over many years can put others in the home at risk of mesothelioma. People who work with high levels of asbestos can reduce the risk of bringing home asbestos fibers by showering and changing clothes before leaving work.
- A family history of Mesothelioma: If a parent, sibling or child has mesothelioma, you may have an increased risk of this disease.
- Radiation therapy to the chest: If you had radiation therapy for cancer in your chest, you might have an increased risk of mesothelioma.
Mesothelioma Complications
As Pleural Mesothelioma spreads in the chest, it puts pressure on the structures in that area. This can cause complications, such as:
- Difficulty Breathing
- Chest Pain
- Difficulty Swallowing
- Pain caused by pressure on the nerves and spinal cord
- Accumulation of fluid (Pleural Effusion) in the chest, which can compress the lung nearby and make breathing difficult.
Mesothelioma Prevention
Reducing your exposure to asbestos may lower your risk of Mesothelioma. Find out whether you work with asbestos. Most patients with Mesothelioma were exposed to the asbestos fibers at work. Workers who may encounter asbestos fibers include:
- Asbestos Miners
- Electricians
- Plumbers
- Pipefitters
- Insulators
- Shipyard Workers
- Demolition Workers
- Brake Mechanics
- Selected Military Personnel
- Home Remodelers
Be safe around Asbestos in your Home and Workplace
Follow all safety precautions in your workplace, such as wearing protective equipment. Older homes and buildings may contain asbestos. In many cases, it’s more dangerous to remove the asbestos than it is to leave it intact. Breaking up asbestos may cause fibers to become airborne, where they can be inhaled.
Detailed clinical data, computerized tomography CT, MRI, PET scans info, pleural effusion test, elevated biomarker levels, genetic and metabolic information, lung tumor tissue biopsy, pathology annotations associated with the Malignant Mesothelioma patient’s specimens is provided to a valued customer for drug discover, development and research. The Malignant Mesothelioma sera (serum), plasma and peripheral blood mononuclear cells (PBMC) biofluid samples are processed from patients peripheral whole-blood using customized collection and processing protocols provided by the researcher.
Bay Biosciences is a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens and human bio-fluid collections from cancer (tumor) tissue, cancer sera (serum), cancer plasma, cancer PBMC and human tissue samples from most other therapeutic areas and diseases.
Bay Biosciences maintains and manages it’s own bio-repository, human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and from normal healthy donors available in all formats and types. Our biobank procures and stores fully consented, deidentified and institutional review boards (IRB) approved human tissue samples and matched controls.
All our human human tissue collections, human specimens and human bio-fluids are provided with detailed samples associated patient’s clinical data. This critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers and genetic information. Patient’s data is extremely valuable for researchers and is used to help identify new effective treatments (drug discovery & development) in oncology, other therapeutic areas and diseases. This clinical information is critical to demonstrate their impact, monitor the safety of medicines, testing & diagnostics, and generate new knowledge about the causes of disease and illness.
Bay Biosciences banks wide variety of human tissue samples and biological samples including cryogenically preserved -80°C, fresh, fresh frozen tissue samples, tumor tissue samples, FFPE’s, tissue slides, with matching human bio-fluids, whole blood and blood derived products such as serum, plasma and PBMC’s.
Bay Biosciences is a global leader in collecting and providing human tissue samples according to the researchers specified requirements and customized, tailor made collection protocols. Please contact us anytime to discuss your special research projects and customized human tissue sample requirements.
Bay Biosciences provides human tissue samples (human specimens) from diseased and normal healthy donors; including peripheral whole-blood, amniotic fluid, bronchoalveolar lavage fluid (BAL), sputum, pleural effusion, cerebrospinal fluid (CSF), serum (sera), plasma, peripheral blood mononuclear cells (PBMC’s), saliva, Buffy coat, urine, stool samples, aqueous humor, vitreous humor, kidney stones, renal calculi, nephrolithiasis, urolithiasis and other bodily fluids from most diseases including cancer. We can also procure most human bio-specimens and can do special collections and requests of human samples that are difficult to find. All our human tissue samples are procured through IRB approved clinical protocols and procedures.
In addition to the standard processing protocols Bay Biosciences can also provide human plasma, serum, PBMC bio-fluid samples using custom processing protocols, you can buy donor specific sample collections in higher volumes and specified sample aliquoting from us. Bay Biosciences also provides human samples from normal healthy donors, volunteers, for controls and clinical research, contact us Now.
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