Bay Biosciences supplies, therefore, high-quality, clinical-grade, fresh frozen biopsy tumor tissue samples from metastatic non-small cell lung cancer (NSCLC) patients. In addition to FFPE tumor tissue blocks, we provide matched:

The biofluid samples from metastatic NSCLC patient’s peripheral whole blood using customized collection and processing protocols.

Metastatic Cancer

Doctors call cancer that spreads from where it originally started to a distant part of the body metastatic cancer. Furthermore, for many types of cancer, they also call it stage IV (stage 4) cancer.

In addition, they refer to the process by which cancer cells spread to other parts of the body as metastasis. Moreover, when they observe metastatic cancer cells under a microscope and conduct histopathology tests, they find features like those of the primary cancer and not like the cells in the place where they find the metastatic cancer. Thus, doctors can tell that it is cancer that has spread from another part of the body.

In metastasis, cancer cells break away from their original formation site or the primary cancer location; subsequently, they travel through the blood or lymph system, and ultimately form new tumors (metastatic tumors) in other parts of the body. Moreover, the primary tumor is of the same type as the metastatic tumor.

Metastatic Non-Small Cell Lung Cancer (NSCLC) Locations

Primary Non-small cell lung cancer (NSCLC) can metastasize to different body regions. Specifically, the cancer can develop metastases in the brain/head, thorax, abdomen, and extremities. For instance, the brain/head can experience metastases in the brain, eyes, nasal sinuses, and gingiva.

Meanwhile, the thorax can harbor metastases in the lungs, pleura, pericardium, and accumulation of pleural/pericardial fluid. Furthermore, the abdomen can show metastases in the liver, adrenal glands, pancreas, spleen, kidneys, gastrointestinal tract, peritoneum, and abdominal lymph nodes. Finally, the extremities can have metastases in muscle, bone, bone marrow, and skin.

Where lung cancer spreads?

Doctors call a cancer that spreads to another part of the body a secondary cancer or metastasis. Not all lung cancers will spread; however, if the cancer does spread, certain parts of the body are more likely to be affected. Specifically, the most common areas for lung cancer to spread to are:

  • Nearby lymph nodes or, alternatively, a single distant lymph node
  • The brain
  • Bones
  • The liver
  • Other parts of the lung or, in some cases, the other lung
  • The adrenal glands (which are small hormone glands just above your kidney)

 

Non-small Cell Lung Cancer (NSCLC) Genetics

Lung cancer gene mutations help doctors decide effective treatment plans; therefore, understanding certain lung cancer biomarkers allows doctors to treat patients effectively with the right treatment plans.

Moreover, doctors probably observe EGFR (epidermal growth factor receptor) as the most common genetic mutation. In addition, they also refer to it as a “driver mutation,” which means that the cancer started because of the EGFR mutation in a patient.

Specifically, about 10%-15% of non-small-cell lung cancers show EGFR positivity, indicating that these cancers have a mutation in the EGFR gene. Furthermore, young adult patients, non-smokers, women, patients of Asian heritage, and patients with lung adenocarcinoma commonly have EGFR gene mutations, and these groups are considered high risk.

Additionally, the following are some of the common genetic biomarkers that doctors test for the diagnosis of non-small cell lung cancer (NSCLC):

  • ALK
  • BRAF
  • EGFR
  • HER2
  • ROS1
  • MET
  • NTRK
  • RET

Biospecimens

Bay Biosciences is, indeed a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens, and human bio-fluid collections.

Specifically, aamples available include cancer (tumor) tissue, cancer serum, cancer plasma, cancer, peripheral blood mononuclear cells (PBMC). and human tissue samples from most other therapeutic areas and diseases.

Moreover, Bay Biosciences maintains and manages its own biorepository, the human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and from normal healthy donors available in all formats and types.

In fact, our biobank procures fully consented, de-identified and institutional review boards (IRB) approved human tissue samples and matched controls.

Additionally, all our human tissue collections, human specimens and human bio-fluids are provided with detailed, samples associated patient’s clinical data.

In particular, critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers, and genetic information.

Moreover, patient’s data is extremely valuable for researchers and is used to help identify new effective treatments (drug discovery & development) in oncology, and other therapeutic areas and diseases.

Specifically, Bay Biosciences banks wide variety of human tissue samples and biological samples, including cryogenically preserved at – 80°C.

For example fresh frozen tissue samples, tumor tissue samples, formalin-fixed paraffin-embedded (FFPE), tissue slides, with matching human bio-fluids, whole blood and blood-derived products such as serum, plasma and PBMC.

Furthermore, Bay Biosciences is a global leader in collecting and providing human tissue samples according to the specified requirements and customized, tailor-made collection protocols.

Therefore, please contact us anytime to discuss your special research projects and customized human tissue sample requirements.

Types of Biospecimens

Bay Biosciences provides human tissue samples (human specimens) from diseased and normal healthy donors which includes:

Customized Collections

Moreover, we can also procure most human bio-specimens, furthermore; we offer special collections and requests for human samples that are difficult to find. All our human tissue samples are procured through IRB-approved clinical protocols and procedures.

In addition to the standard processing protocols, Bay Biosciences can also provide human plasma, serum, and PBMC bio-fluid samples using custom processing protocols. Additionally you buy donor-specific collections in higher volumes and specified sample aliquots from us.

Furthermore, Bay Biosciences also provides human samples from normal healthy donors; volunteers, for controls and clinical research, contact us Now.

 

  • 日本のお客様は、ベイバイオサイエンスジャパンBay Biosciences Japanまたはhttp://baybiosciences-jp.com/contact/までご連絡ください。