Bay Biosciences provides high-quality, matched fresh frozen sera (serum),  plasma, and peripheral blood mononuclear cells (PBMC) bio-fluids from patients diagnosed with metastatic triple negative breast cancer (TNBC).

Moreover, the sera (serum), plasma and PBMC bio-fluids are processed from metastatic TNBC patient’s peripheral whole-blood using customized collection and processing protocols.

In addition, the matched bio-fluids are collected from unique patients with metastatic triple negative breast cancer and are provided to a valued pharmaceutical customer for research, development and drug discovery.

 

Triple-Negative Breast Cancer (TNBC) Overview

Triple-negative breast cancer (TNBC) is a cancer that tests negative for estrogen receptors (ER), progesterone receptors (PR), and excess HER2 protein. Consequently, these results mean the growth of the cancer is not fueled by the hormones. Such as estrogen and progesterone, or by the HER2 protein. Therefore, triple-negative breast cancer does not respond to hormonal therapy medicines or medicines that target HER2 protein receptors.

Moreover, about 10-20% of breast cancers are triple-negative breast cancers. For researchers, there is intense interest in discovering new medications that can treat TNBC breast cancer. In particular, studies are investigating whether certain medications can interfere with the processes. That cause triple-negative breast cancer to grow.

Notably, triple-negative breast cancer (TNBC) tends to be more common in women younger than age 40. And, who have a BRCA1 mutation. Furthermore, triple-negative breast cancer differs from other types of invasive breast cancer. Moreover, they grow and spread faster, have limited treatment options, and a worse prognosis (outcome).

In addition, about 10-20% of breast cancers which test negative for both hormone receptors (ER & PR negative). In addition, excess HER2 (negative) are triple-negative. Since hormones aren’t fueling the cancer growth, it follows that the cancer is unlikely to respond to hormonal therapy medicines. Including tamoxifen and aromatase inhibitors.

Moreover, triple-negative breast cancer also is unlikely to respond to medicines that target the HER2 protein, such as Enhertu, Herceptin (trastuzumab), Kadcyla (T-DMA), Nerlynx (neratinib), Perjeta (pertuzumab), or Tykerb (lapatinib).

TNBC Features

  • Triple-negative breast cancer (TNBC) is considered to be more aggressive and have a poorer prognosis than other types of breast cancer. This is primarily because there are fewer targeted medicines that treat triple-negative breast cancer. Furthermore, studies have shown that triple-negative breast cancer is more likely to spread (metastasize). Beyond the breast into other distant organs and more likely to recur (come back) after treatment.
  • In addition, triple-negative breast cancer (TNBC) tends to be higher grade than other types of breast cancers. Specifically, the higher the grade, the less the cancer cells resemble normal healthy breast cells in their appearance and growth patterns. On a scale of 1 to 3, triple-negative breast cancer often is grade 3.
  • Moreover, triple-negative breast cancer (TNBC) usually is a cell type called Basal-like. Which means that the cells resemble the basal cells that line the breast ducts. Consequently, basal-like cancers tend to be more aggressive, higher grade cancers, just like triple-negative breast cancers. Notably, most but not all basal-like breast cancers are triple negative, and most but not all triple-negative breast cancers are basal-like.

TNBC Signs & Symptoms

Triple-negative breast cancer (TNBC) has the same signs and symptoms as other common types of breast cancer. In fact, the most common symptom of breast cancer is a new lump or mass.

Specifically, a painless, hard mass that has irregular edges is more likely to be cancer; however, breast cancers can be tender, soft, or round. Additionally, they can even be painful. For this reason, it’s important to have any new breast mass, lump, or breast change checked by an experienced health care professional.

Furthermore, other symptoms of breast cancer include:

  • First, swelling of all or part of a breast (even if no lump is felt)
  • Second, skin dimpling (sometimes looking like an orange peel)
  • Third, breast or nipple pain
  • Moreover, nipple retraction (turning inward)
  • Furthermore, nipple or breast skin that is red, dry, flaking or thickened
  • In addition, nipple discharge (other than breast milk)
  • Finally, swollen lymph nodes (Sometimes a breast cancer can spread to lymph nodes under the arm or around the collar bone and cause a lump or swelling there, even before the original tumor in the breast is large enough to be felt.)

Triple-Negative Breast Cancer (TNBC) Treatment

Triple-negative breast cancer (TNBC) has fewer treatment options than other types of invasive breast cancer. This is because, specifically, the cancer cells do not have the estrogen or progesterone receptors or enough of the human epidermal growth factor receptor 2 (HER2) protein to make hormone therapy or targeted drugs work.

If, however, the cancer has not spread to distant sites, surgery is, indeed, an option. For instance, chemotherapy might be given first to shrink a large tumor, followed by surgery. Additionally, it might also be given after surgery to reduce the chances of the cancer coming back.

Furthermore, radiation might also be an option depending on certain features of the tumor. Because, consequently, hormone therapy and HER2 drugs are not choices for women with triple-negative breast cancer, chemotherapy is often used. In cases where, on the other hand, the cancer has spread to other parts of the body (stage IV), chemotherapy and other treatments that can be considered include PARP inhibitors, platinum chemotherapy, or immunotherapy.

 

Biospecimens

Bay Biosciences is, indeed a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens, and human bio-fluid collections.

Specifically, aamples available include cancer (tumor) tissue, cancer serum, cancer plasma, cancer, peripheral blood mononuclear cells (PBMC) and human tissue samples from most other therapeutic areas and diseases.

Moreover, Bay Biosciences maintains and manages its own biorepository, the human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and from normal healthy donors available in all formats and types.

In fact, our biobank procures and stores fully consented, de-identified and institutional review boards (IRB) approved human tissue samples and matched controls.

Additionally, all our human tissue collections, human specimens and human bio-fluids are provided with detailed, samples associated patient’s clinical data.

In particular, critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers, and genetic information.

Moreover, researchers find patient’s data extremely valuable and use it to help identify new effective treatments (drug discovery & development) in oncology, and other therapeutic areas and diseases.

Specifically, Bay Biosciences banks wide variety of human tissue samples and biological samples, including cryogenically preserved at – 80°C.

For example fresh frozen tissue samples, tumor tissue samples, formalin-fixed paraffin-embedded (FFPE), tissue slides, with matching human bio-fluids, whole blood and blood-derived products such as serum, plasma and PBMC.

Furthermore, Bay Biosciences is a global leader in collecting and providing human tissue samples according to the specified requirements and customized, tailor-made collection protocols.

Therefore, please contact us anytime to discuss your special research projects and customized human tissue sample requirements.

Types of Biospecimens

Bay Biosciences provides human tissue samples (human specimens) from diseased and normal healthy donors which includes:

  • Firstly, Peripheral whole-blood
  • Secondly, Amniotic fluid
  • Third, Bronchoalveolar lavage fluid (BAL)
  • Moreover, Sputum
  • Furthermore, Pleural effusion
  • Next, Cerebrospinal fluid (CSF)
  • Also, Serum (sera)
  • Likewise, Plasma
  • In addition, Peripheral blood mononuclear cells (PBMC)
  • For example, Saliva
  • Also, Buffy coat
  • Moreover, Urine
  • Furthermore, stool samples
  • Next, Aqueous humor
  • Likewise, Vitreous humor
  • Lastly, Kidney stones (renal calculi)
  • Finally, Other bodily fluids from most diseases including cancer.

Moreover, we can also procure most human bio-specimens, furthermore; we offer special collections and requests for human samples that are difficult to find. All our human tissue samples are procured through IRB-approved clinical protocols and procedures.

In addition to the standard processing protocols, Bay Biosciences can also provide human plasma, serum, and PBMC bio-fluid samples using custom processing protocols. Additionally you buy donor-specific collections in higher volumes and specified sample aliquots from us.

Furthermore, Bay Biosciences also provides human samples from normal healthy donors; volunteers, for controls and clinical research, contact us Now.

 

  • 日本のお客様は、ベイバイオサイエンスジャパンBay Biosciences Japanまたはhttp://baybiosciences-jp.com/contact/までご連絡ください。