Bay Biosciences provides cryogenically frozen (-80) fresh frozen high quality, clinical grade serum (sera), plasma and peripheral blood mononuclear cells (PBMC) biofluid samples from unique Chronic Nonspecific Interstitial Pneumonia (NSIP) pulmonary disease patients,
Detailed clinical data and pathology annotations, drug information, smoking history, and other clinical information associated serum (sera), plasma and PBMC)biofluid samples from the Nonspecific Interstitial Pneumonia (NSIP) patients is provided to a valued pharmaceutical customer for development, discovery and clinical research.
Interstitial Lung disease
Interstitial lung disease (ILD) are group of diffuse parenchymal lung disorders that are classified according to their specific clinical, radiological and histopathological features. ILD’s are a large group of disorders, most of which cause progressive scarring of lung tissue. The scarring associated with interstitial lung disease eventually affects the ability to breathe and get enough oxygen into your bloodstream. Interstitial lung disease (ILD) can be caused by long-term exposure to hazardous materials, such as asbestos. Some types of autoimmune diseases, such as rheumatoid arthritis, also can cause interstitial lung disease. In some cases, however, the causes remain unknown. Once lung scarring occurs, it’s generally irreversible. Medications may slow the damage of interstitial lung disease (ILD), but many people never regain full use of their lungs. Lung transplant is an option for some patients who have interstitial lung disease (ILD).
Nonspecific interstitial pneumonia (NSIP) Overview
Nonspecific interstitial pneumonia (NSIP) is a rare disorder that affects the tissue that surrounds and separates the tiny air sacs of the lungs. These air sacs, called the alveoli, are where the exchange of oxygen and carbon dioxide takes place between the lungs and the bloodstream. With interstitial pneumonia the mesh-like walls of the alveoli become inflamed. The pleura (a thin covering that protects and cushions the lungs and the individual lobes of the lungs) might become inflamed as well. Over time, this inflammation can lead to permanent scarring of the lungs.
NSIP can be found in a number of different diseases, including connective tissue disorders (diseases that affect the structural tissues in the body), reactions to certain medications, HIV, as well as other medical conditions. Some patients also have idiopathic NSIP, which means that the specific cause of the lung disease is unknown.
Nonspecific interstitial pneumonia has only been defined for a relatively short time, and not much is known about how common it is versus other kinds of interstitial pneumonia. Caucasians patients account for most of the NSIP cases in the United States, with an average age of onset of the disease between the ages of 40 and 50 years. There does not seem to be a correlation between cigarette smoking and NSIP.
Types of Nonspecific interstitial pneumonia (NSIP)
There are two primary forms of NSIP, cellular and fibrotic. The cellular form is defined mainly by inflammation of the cells of the interstitium. The fibrotic form is defined by thickening and scarring of lung tissue. This scarring is known as fibrosis and is irreversible. When the lung tissue thickens or becomes scarred, it does not function as effectively. Breathing becomes less efficient, and can lead to lower levels of oxygen in the blood. Both inflammation and fibrosis may be present at the same time. Generally, the prognosis is better for patients with the cellular form of NSIP as inflammation is often reversible but fibrosis is permanent.
Signs and Symptoms of Nonspecific interstitial pneumonia (NSIP)
Following are the common signs and symptoms of nonspecific interstitial pneumonia (NSIP):
- A dry cough
- Shortness of breath which may occur after effort or become worse over time
- Difficult or labored breathing
- Fatigue
- Clubbing, or enlargement of the fingertips at the base of the nails. Clubbing may be present due to a lack of oxygen in the blood. Generally, this occurs in only about 10% of people with NSIP.
Causes of Nonspecific interstitial pneumonia (NSIP)
Causes of nonspecific interstitial pneumonia (NSIP) are unknown. Many researchers believe that it is an autoimmune disease, because of the similarities between NSIP and certain connective tissue diseases, such as systemic sclerosis. Some researchers suggest that genes are involved, with heredity playing a role in its development. Inhaling chemicals or dust, use of certain chemotherapy drugs, or radiation treatment could result in the lung damage associated with NSIP.
Diagnosis of Nonspecific interstitial pneumonia (NSIP)
Because the symptoms of nonspecific interstitial pneumonia resemble those of other diseases, especially Idiopathic pulmonary fibrosis, tests must be performed to rule out other related disorders. The diagnosis of the disease depends on a combination of clinical, radiologic and other factors.
Pulmonary function test may be ordered to assess how well the lungs are working and the rate of carbon dioxide and oxygen exchange.
Generally, a high-resolution computed tomography (CT) scan is performed to help diagnose NSIP. CT scans of patients with NSIP show a typical “ground glass” pattern that represents interstitial inflammation, and is usually seen in the cellular form. Scarring or fibrosis, will be seen in the fibrotic form. Occasionally, further workup is needed depending on the CT findings and clinical history. These tests can include obtaining tissue of the lung.
The methods of obtaining tissue can be through a bronchoscopy or through a surgical procedure where a portion of the lung is removed. A bronchoscopy uses a flexible tube called a bronchoscope that is inserted into the bronchi (air passages) of the lung, and a saline fluid is passed through the bronchoscope.
After coming into contact with the airways and alveoli, the fluid is aspirated (sucked out) and collected for further analysis. This is called a bronchoalveolar lavage (BAL). Elevated levels of lymphocytes (white blood cells) in the fluid have been detected in over half of patients with NSIP, but this is not always specific to this disease. Biopsies may also be taken during the bronchoscopy to get a closer look at the lung tissue for inflammation or scarring. In many patients, a surgical lung biopsy may be necessary to make a definitive diagnosis.
Bay Biosciences is a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens and human bio-fluid collections from cancer (tumor) tissue, cancer serum, cancer plasma cancer PBMC and human tissue samples from most other therapeutic areas and diseases.
Bay Biosciences maintains and manages it’s own bio-repository, human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and from normal healthy donors available in all formats and types. Our biobank procures and stores fully consented, deidentified and institutional review boards (IRB) approved human tissue samples and matched controls.
All our human human tissue collections, human specimens and human bio-fluids are provided with detailed samples associated patient’s clinical data. This critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers and genetic information. Patient’s data is extremely valuable for researchers and is used to help identify new effective treatments (drug discovery & development) in oncology, other therapeutic areas and diseases. This clinical information is critical to demonstrate their impact, monitor the safety of medicines, testing & diagnostics, and generate new knowledge about the causes of disease and illness.
Bay Biosciences banks wide variety of human tissue samples and biological samples including cryogenically preserved -80°C, fresh, fresh frozen tissue samples, tumor tissue samples, FFPE’s, tissue slides, with matching human bio-fluids, whole blood and blood derived products such as serum, plasma and PBMC’s.
Bay Biosciences is a global leader in collecting and providing human tissue samples according to the researchers specified requirements and customized, tailor made collection protocols. Please contact us anytime to discuss your special research projects and customized human tissue sample requirements.
Bay Biosciences provides human tissue samples (human specimens) from diseased and normal healthy donors; including peripheral whole-blood, amniotic fluid, bronchoalveolar lavage fluid (BAL), sputum, pleural effusion, cerebrospinal fluid (CSF), serum (sera), plasma, peripheral blood mononuclear cells (PBMC’s), saliva, Buffy coat, urine, stool samples, aqueous humor, vitreous humor, kidney stones, renal calculi, nephrolithiasis, urolithiasis and other bodily fluids from most diseases including cancer. We can also procure most human bio-specimens and can do special collections and requests of human samples that are difficult to find. All our human tissue samples are procured through IRB approved clinical protocols and procedures.
In addition to the standard processing protocols Bay Biosciences can also provide human plasma, serum, PBMC bio-fluid samples using custom processing protocols, you can buy donor specific sample collections in higher volumes and specified sample aliquoting from us. Bay Biosciences also provides human samples from normal healthy donors, volunteers, for controls and clinical research, contact us Now.
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