Bay Biosciences provides high quality, clinical grade pediatric tumor tissue specimens from various cancer indications to a valued pharmaceutical customer for drug discover, research and development.

Moreover, the pediatric caner tumor tissue samples are collected from multiple cancer indications including Leukemia, Wilms tumor, Neuroblastoma and Retinoblastoma.

Pediatric Leukemia

Leukemias, which are cancers of the bone marrow and blood, are, in fact, the most common childhood cancers. Specifically, the most common types of leukemias in children are acute lymphocytic leukemia (ALL) and acute myeloid leukemia (AML). These leukemias can, consequently, cause bone and joint pain, tigue, fever, weakness, headaches, pale skin, bleeding or bruising, weight loss, and other symptoms.

Wilms Tumor

In addition, Wilms tumor, which doctors also call Nephroblastoma, is a rare type of cancer that starts in the kidney. Notably, Wilm’s tumor most often occurs in just one kidney; however, it can sometimes appear in both kidneys at the same time. Doctors most often diagnose it in children about 3 to 4 years old, and, for this reason, they find it uncommon in older children and adults. Furthermore, it can show up as a swelling or lump in the belly. Sometimes, in fact, the child might have other symptoms, such as fever, pain, nausea, and poor appetite.

Neuroblastoma

Neuroblastoma is a cancer that develops from immature nerve cells found in several areas of the body. Specifically, neuroblastoma most commonly arises in and around the adrenal glands, which have similar origins to nerve cells and sit atop the kidneys. In particular, the tumor can start anywhere, but it usually starts in the belly (abdomen), where, it is noticed as swelling.

Furthermore, it can also cause other symptoms, like bone pain and fever. Essentially, neuroblastoma starts in early forms of nerve cells found in a developing embryo or fetus. Consequently, this type of cancer develops in infants and young children.

Retinoblastoma

Retinoblastoma, on the other hand, is a rare form of eye cancer that begins in the retina, which is the sensitive lining on the inside of the eye. In addition, the retina consists of nerve tissue that senses light as it comes through the front of the eye. Moreover, the retina sends signals through the optic nerve to the brain, where those signals interpret images.

Notably, retinoblastoma most commonly affects young children, but it can also rarely affect adults. Indeed, retinoblastoma is the most common form of cancer affecting the eye in children; it may occur in one or both eyes.

It accounts for about 2% of childhood cancers; moreover, it mostly occurs in children around the age of two, and, in fact, is rarely found in children older than six.

Retinoblastoma occurs when, specifically, nerve cells in the retina develop genetic mutations. Consequently, these mutations cause the cells to continue growing and multiplying when healthy cells would die.

As a result, this accumulating mass of cells forms a tumor. Furthermore, retinoblastoma cells can invade further into the eye and nearby structures. Additionally, retinoblastoma can also spread or metastasize to surrounding tissue and other areas of the body, including the brain and spine.

Lymphomas

Childhood lymphoma usually starts in the lymph nodes or lymph tissues (like the tonsils); however, it can also affect bone marrow and other organs. Consequently, doctors divide lymphoma into 2 types:

  • Hodgkin lymphoma is similar in both children and adults, and the same treatments tend to be effective for both.
  • Non-Hodgkin lymphoma on the other hand, Non-Hodgkin lymphoma tends to grow more quickly in children than in adults. Nevertheless, children may also respond better to treatment.

Sarcomas

There are 2 main types of primary bone cancer that develop in children:

  • Osteosarcoma: To begin with, Osteosarcoma is most common in teens; thus, doctors often see osteosarcoma develop in the areas where bones grow quickly. 
  • Ewing sarcoma: In contrast, Ewing sarcoma, which is less common than osteosarcoma, tends to start in the hips, ribs, or shoulder blades.

Moreover, sarcomas can develop at any age; however, doctors see more cases in older children and teenagers. Furthermore, bone cancer can also begin as cancer elsewhere in the body that then spreads to the bones (metastasizes). In some cases, secondary bone cancer develops in response to treatments for a different type of cancer.

Biospecimens

biospecimens

Bay Biosciences is a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens, and human bio-fluid collections.

Moreover, human biospecimens are available including tumor tissue, serum, plasma and PBMC samples from most other therapeutic areas.

Furthermore, Bay Biosciences maintains and manages its own biorepository, the human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and likewise normal healthy donors for controls. Additionally, available in all formats and types.

In fact, our biobank procures and stores fully consented, de-identified and institutional review boards (IRB) approved human tissue samples, human biofluids such as serum samples, plasma samples from various diseases and matched controls.

Also, all our human tissue collections, human biospecimens and human biofluids are provided with detailed, samples associated patient’s clinical data.

In fact, this critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers, and genetic information.

Additionally, researchers find the patient’s data associated with the human biospecimens extremely valuable and use it to help identify new effective treatments (drug discovery & development) in oncology, as well as in other therapeutic areas and diseases.

Bay Biosciences banks wide variety of human tissue samples and human biological samples, including fresh frozen human biospecimens cryogenically preserved at – 80°C.

For example fresh frozen tissue samples, tumor tissue samples, formalin-fixed paraffin-embedded (FFPE), tissue slides, with matching human bio-fluids, whole blood and blood-derived products such as human serum, human plasma and human PBMCs.

Bay Biosciences is a global leader in collecting and providing human tissue samples according to the specified requirements and customized, tailor-made collection protocols.

Please contact us anytime to discuss your special research projects and customized human tissue sample requirements.

Types of Biospecimens

Bay Biosciences provides human tissue samples (human specimens) and human biofluids from diseased and normal healthy donors which includes:

Moreover, we can also procure most human biospecimens and human biofluids, special collections and requests for human samples that are difficult to find. All our human tissue samples and human biofluids are procured through IRB-approved clinical protocols and procedures.

In addition to the standard processing protocols, Bay Biosciences can also provide human biofluids such as  human plasma, human serum, and human PBMCs bio-fluid samples using custom processing protocols; you buy donor-specific collections in higher volumes and specified sample aliquots from us.

Bay Biosciences also provides human biospecimens from normal healthy donors; volunteers, for controls and clinical research, Contact us Now.