Bay Biosciences provides fresh frozen (-80C) high quality clinical grade sera (serum), plasma and peripheral blood mononuclear cells (PBMC) biofluid samples processed from unique sarcoidosis patients.

Moreover, the serum, plasma and PBMCs are processed from sarcoidosis patient’s peripheral whole-blood using customized collection and processing protocols.

In addition, detailed clinical data, biomarker information, annotations, and patients history associated with the sarcoidosis samples is provided to a valued customer for drug discovery, development and research. 

Sarcoidosis Overview

Sarcoidosis is a condition involving the growth of persistent or inappropriate granulomas or clumps of inflammatory cells. In fact, for some people, symptoms will resolve on their own without needing treatment.

Moreover, sarcoidosis is a chronic inflammatory condition that leads to the formation of persistent granulomas or clumps of inflammatory cells. Although it can occur in any organ, most cases involve the lungs.

Consequently,  granulomas can damage organs and may require treatment. This is particularly true if they begin to take up a significant portion of an organ or persist for a long time.

Currently, there is no cure for sarcoidosis, although some cases resolve without medical intervention.

Causes of Sarcoidosis

Furthermore, granulomas form as part of the immune response, but they  typically break up after the body removes the inflammatory trigger.

In essence, sarcoidosis involves the development of granulomas that form or linger when they are no longer necessary.

Interestingly, researchers are still not sure why or how sarcoidosis occurs. However, there may be an association with the following triggers:

  • Chemicals, such as beryllium,
  • Dust
  • Pollution
  • Viruses and bacteria.

Additionally, genetics may also play a role in sarcoidosis, but more research is necessary to understand this.

Moreover, genetics may also play a role in sarcoidosis, but more research is necessary to understand this.

Furthermore, most sarcoidosis cases involve or begin in the lungs or the surrounding lymph nodes and glands. However, sarcoidosis can affect any organ in the body.

Symptoms of Sarcoidosis

Sarcoidosis symptoms can vary from person to person. Moreover, they may also vary depending on the location of the granuloma and the size of the affected organ.

Interestingly, some people with sarcoidosis may not have any symptoms. Specifically, between 30% and 60% of people with sarcoidosis of the lung have no symptoms.

In fact, in these cases, a doctor may diagnose it during scans for a different issue. On the other hand, people with acute sarcoidosis develop symptoms suddenly, but these symptoms resolve within a few months or years.

Conversely, chronic sarcoidosis occurs when a person’s symptoms progress. Consequently, granulomas may spread to multiple organs or significantly affect an organ’s function.

Moreover, sarcoidosis usually affects the lungs. Furthermore, the most common symptoms include a persistent dry cough and shortness of breath . Some people may also experience chest pain.

Risk Factors

According to a 2024 review, sarcoidosis affects between  2 and 160 of every 100,000 people worldwide.

Furthermore, risk factors that may affect a person’s chances of developing the condition  include:

  • Firstly, family history of sarcoidosis
  • Secondly, being older than 55 years
  • Additionally, African or Scandinavian descent
  • Also, biological female sex
  • Moreover, workplace exposure to mold, insecticides, or other substances that cause inflammation
  • Furthermore, certain medical conditions, such as lymphoma, which is a type of cancer
  • Lastly, certain medications, such as monoclonal antibodies, which may be part of cancer treatment
  • Ultimately, more research is necessary to understand the link between these risk factors and sarcoidosis.

Stages of Sarcoidosis

According to the  American Lung Association, healthcare professionals may categorize lung sarcoidosis based on something called “scadding stages.”

Furthermore, each stage in these systems uses the location of granulomas to predict whether or not a person will need treatment. Additionally, people can move between these stages and may have granulomas affecting other organs at any stage.

The scadding stages are as follows:

  • Stage 0: No signs of sarcoidosis in the lungs and lymph nodes according to X-rays.
  • In contrast, Stage 1: Granulomas cause enlargement of the chest lymph nodes. Moreover, some people develop Lofgren syndrome, which is a type of sarcoidosis that typically resolves without treatment.
  • Next, Stage 2: Granulomas cause enlargement of the chest lymph nodes and nodules in the lungs. Specifically, nodules are small lumps or clumps of cells.
  • Following that, Stage 3: Granulomas are only present in the lung tissue.
  • Finally, Stage 4: A person has pulmonary fibrosis, which is permanent scarring of the lung tissue. This is the most severe form of lung sarcoidosis, and damage tends to be irreversible.

In conclusion, healthcare professionals may also rank sarcoidosis from mild to severe depending on how many organs it affects.

Diagnosis of Sarcoidosis

Recognizing the signs of sarcoidosis can be challenging. Moreover, even if someone has symptoms, it can take  months or years to get a diagnosis because many more common conditions share similar symptoms.

In fact, diagnoses may occur during examinations or tests for other health conditions; for example, chest X-rays for:

If a doctor suspects sarcoidosis, they may begin with a physical examination and a review of the person’s medical history.

Furthermore, additional tests used to diagnose sarcoidosis may include:

  • Imaging tests, including:
  • Examinations of the eyes
  • Blood tests to assess organ function or change; in particular, measuring kidney enzymes and markers
  • Biopsies of organ tissues
  • Neurological tests, such as:
    • Nerve condition tests
    • Spinal taps, in which a doctor removes cerebrospinal fluid for testing
    • Electromyography, which records the electrical activity of muscle tissue
  • Heart function tests

Treatment of Sarcoidosis

According to the United Kingdom’s  National Health Service (NHS), most people do not require treatment for sarcoidosis. In fact, symptoms may resolve on their own in a few months or years.

However, if symptoms are severe or do not resolve, a person may need medical treatment.

Furthermore, the exact treatment a person requires may depend on the organs sarcoidosis affects. According to the  National Heart, Lung, and Blood Institute, medications to treat sarcoidosis may include:

  • Antibiotics to manage skin symptoms
  • Corticosteroids
  • Immune-suppressing medications
  • Colchicine (Colcrys) to relieve joint pain

In addition, treating complications is also important.

Specifically, other treatments may help address complications of sarcoidosis. This  includes:

  • Hormone replacement therapy (HRT)
  • Medications to lower high blood pressure, including ACE inhibitors and beta-blockers
  • Oxygen therapy or inhaled corticosteroids to address breathing issueSeizure medications
  • Physical therapy
  • Surgery to remove brain tumors
  • Seizure medications

Moreover, doctors may also recommend lifestyle changes, such as staying hydrated and avoiding excess sunlight.

Biospecimens

biospecimens

Bay Biosciences is a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens, and human bio-fluid collections.

Moreover, human biospecimens are available including tumor tissue, serum, plasma and PBMC samples from most other therapeutic areas.

Furthermore, Bay Biosciences maintains and manages its own biorepository, the human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and likewise normal healthy donors for controls. Additionally, available in all formats and types.

In fact, our biobank procures and stores fully consented, de-identified and institutional review boards (IRB) approved human tissue samples, human biofluids such as serum samples, plasma samples from various diseases and matched controls.

Also, all our human tissue collections, human biospecimens and human biofluids are provided with detailed, samples associated patient’s clinical data.

In fact, this critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers, and genetic information.

Additionally, researchers find the patient’s data associated with the human biospecimens extremely valuable and use it to help identify new effective treatments (drug discovery & development) in oncology, as well as in other therapeutic areas and diseases.

Bay Biosciences banks wide variety of human tissue samples and human biological samples, including fresh frozen human biospecimens cryogenically preserved at – 80°C.

For example fresh frozen tissue samples, tumor tissue samples, formalin-fixed paraffin-embedded (FFPE), tissue slides, with matching human bio-fluids, whole blood and blood-derived products such as human serum, human plasma and human PBMCs.

Bay Biosciences is a global leader in collecting and providing human tissue samples according to the specified requirements and customized, tailor-made collection protocols.

Please contact us anytime to discuss your special research projects and customized human tissue sample requirements.

Types of Biospecimens

Bay Biosciences provides human tissue samples (human specimens) and human biofluids from diseased and normal healthy donors which includes:

Moreover, we can also procure most human biospecimens and human biofluids, special collections and requests for human samples that are difficult to find. All our human tissue samples and human biofluids are procured through IRB-approved clinical protocols and procedures.

In addition to the standard processing protocols, Bay Biosciences can also provide human biofluids such as  human plasma, human serum, and human PBMCs bio-fluid samples using custom processing protocols; you buy donor-specific collections in higher volumes and specified sample aliquots from us.

Bay Biosciences also provides human biospecimens from normal healthy donors; volunteers, for controls and clinical research, Contact us Now.