Bay Biosciences provides high-quality, fresh frozen, skeletal muscle biopsy (vastus lateralis) with matched fresh frozen sera (serum), plasma, bio-fluids from healthy donors for research.
The sera (serum) and plasma bio-fluid specimens are processed from donors peripheral whole-blood using customized collection and processing protocols.
What is a Muscle Biopsy?
A muscle biopsy is a procedure that removes a small sample of tissue for testing in a laboratory. The test can help your doctor see if you have an infection infection disease in your muscles.
A muscle biopsy is a relatively simple procedure. It’s usually done on an outpatient basis, which means you’ll be free to leave the same day as the procedure. You may receive local anesthesia to numb the area from which the doctor is removing tissue, but you’ll remain awake for the test.
Why is a Muscle Biopsy Done?
A muscle biopsy is performed if you are experiencing problems with your muscle and your doctor suspects an infection or disease could be the cause.
The biopsy can help your doctor rule out certain conditions as a cause of your symptoms. It can also help them make a diagnosis and start a treatment plan.
Your doctor may order a muscle biopsy for various reasons. They may suspect you have:
- A defect in the way your muscles metabolize, or use, energy
- Disease that affects blood vessels or connective tissue, such as polyarteritis nodosa (which causes the arteries to become swollen)
- An infection related to the muscles, such as trichinosis (an infection caused by a type of roundworm)
- Muscular disorder, including types of muscular dystrophy (MD) (genetic disorders that lead to muscle weakness and other symptoms)
Your doctor might use this test to tell if your symptoms are being caused by one of the muscle-related conditions above or by a nerve problem.
The Risks of a Muscle Biopsy
Any medical procedure that breaks the skin carries some risk of infection or bleeding. Bruising is also possible. However, since the incision made during a muscle biopsy is small, especially for needle biopsies, the risk is much lower.
Your doctor will not take a biopsy of your muscle if it was recently damaged by another procedure such as a needle during an electromyography (eMG) test. Your doctor also will not perform a biopsy if there’s known muscle damage that dates back further.
There’s a small chance of damage to the muscle where the needle enters, but this is rare. Always talk with your doctor about any risks before a procedure and share your concerns.
How to Prepare for a Muscle Biopsy
You don’t need to do much to prepare for this procedure. Depending on the type of biopsy you’ll have, your doctor may give you some instructions to carry out before the test. These instructions typically apply to open biopsies.
Prior to a procedure, it’s always a good idea to tell your doctor about any prescription drugs, over-the-counter medications, herbal supplements, and especially blood thinners (including as aspirin) you are taking.
Discuss with them whether you should stop taking the medication before and during the test, or if you should change the dosage.
How a Muscle Biopsy is Performed
There are two different ways to perform a muscle biopsy.
The most common method is called a needle biopsy. For this procedure, your doctor will insert a thin needle through your skin to remove your muscle tissue. Depending on your condition, the doctor will use a certain type of needle.
These include the following:
- Core Needle Biopsy. A medium-sized needle extracts a column of tissue, similar to the way core samples are taken from the earth.
- Fine Needle Biopsy. A thin needle is attached to a syringe, allowing fluids and cells to be drawn out.
- Image-Guided Biopsy. This kind of needle biopsy is guided with imaging procedures, like X-rays or computerized tomography (CT) scans, so your doctor can avoid specific areas like your lungs, liver, or other organs.
- Vacuum-Assisted Biopsy. This biopsy uses suction from a vacuum to collect more cells.
You will receive local anesthesia for a needle biopsy and should not feel any pain or discomfort. In some cases, you may feel some pressure in the area where the biopsy is being taken. Following the test, the area may be sore for about a week.
If the muscle sample is hard to reach, as may be the case with deep muscles, for instance, your doctor may choose to perform an open biopsy. In this case, your doctor will make a small cut in your skin and remove the muscle tissue from there.
If you’re having an open biopsy, you may receive a general anesthesia. This means you will be sound asleep throughout the procedure.
After a Muscle Biopsy
After the tissue sample is taken, it’s sent to a laboratory for testing. It could take up to a few weeks for the results to be ready.
Once the results are back, your doctor may call you or have you come to their office for a follow-up appointment to discuss the findings.
If your results come back abnormal, it could mean you have an infection or disease in your muscles that may be causing them to weaken or die.
Your doctor may need to order more tests to confirm a diagnosis or see how far the condition has progressed. They will discuss your treatment options with you and help you plan your next steps.
Bay Biosciences is a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens, and human bio-fluid collections.
Samples available include cancer (tumor) tissue, cancer serum, cancer plasma, cancer, peripheral blood mononuclear cells (PBMC). and human tissue samples from most other therapeutic areas and diseases.
Bay Biosciences maintains and manages its own biorepository, the human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and from normal healthy donors available in all formats and types.
Our biobank procures and stores fully consented, deidentified and institutional review boards (IRB) approved human tissue samples and matched controls.
All our human tissue collections, human specimens and human bio-fluids are provided with detailed, samples associated patient’s clinical data.
This critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers, and genetic information.
Patient’s data is extremely valuable for researchers and is used to help identify new effective treatments (drug discovery & development) in oncology, and other therapeutic areas and diseases.
Bay Biosciences banks wide variety of human tissue samples and biological samples, including cryogenically preserved at – 80°C.
Including fresh frozen tissue samples, tumor tissue samples, formalin-fixed paraffin-embedded (FFPE), tissue slides, with matching human bio-fluids, whole blood and blood-derived products such as serum, plasma and PBMC.
Bay Biosciences is a global leader in collecting and providing human tissue samples according to the specified requirements and customized, tailor-made collection protocols.
Please contact us anytime to discuss your special research projects and customized human tissue sample requirements.
Types of Biospecimens
Bay Biosciences provides human tissue samples (human specimens) from diseased and normal healthy donors which includes:
- Peripheral whole-blood
- Amniotic fluid
- Bronchoalveolar lavage fluid (BAL)
- Sputum
- Pleural effusion
- Cerebrospinal fluid (CSF)
- Serum (sera)
- Plasma
- Peripheral blood mononuclear cells (PBMC)
- Saliva
- Buffy coat
- Urine
- Stool samples
- Aqueous humor
- Vitreous humor
- Kidney stones (renal calculi)
- Other bodily fluids from most diseases including cancer.
We can also procure most human bio-specimens, special collections and requests for human samples that are difficult to find. All our human tissue samples are procured through IRB-approved clinical protocols and procedures.
In addition to the standard processing protocols, Bay Biosciences can also provide human plasma, serum, and PBMC bio-fluid samples using custom processing protocols; you buy donor-specific collections in higher volumes and specified sample aliquots from us.
Bay Biosciences also provides human samples from normal healthy donors; volunteers, for controls and clinical research, contact us Now.
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