Bay Biosciences provides high quality, clinical grade bio-samples, cryogenically preserved human skeletal muscle biopsy tissue samples from the vastus lateralis (quadricep muscle) with matching sera (serum) and plasma bio-fluid samples.

Detailed clinical data, biomarkers, genetic information associated with the skeletal muscle biopsy tissue samples, pathology annotations is provided to a valued customer for research, development and drug discovery.

What is a Muscle Biopsy?

A muscle biopsy of the vastus lateralis involves extracting a small sample of muscle tissue from the vastus lateralis muscle, typically in the thigh, for analysis.

Furthermore, this procedure is often used in research and clinical settings to investigate various muscle-related conditions.

In addition, it’s usually performed using a needle biopsy technique; however, an open biopsy (surgical incision) may be used in some cases.

Purpose of Muscle Biopsy

Researchers use muscle biopsy is used for the following purposes:

  • Firstly they study muscle metabolism, protein expression, gene expression, and other factors related to muscle function and disease. 
  • Additionally, clinicians diagnosis or assess the severity of muscle diseases like muscular dystrophy, myopathies, and inflammatory myopathies. 
  • Finally, healthcare providers track the effectiveness of treatments for muscle disorder.

Location

The vastus lateralis is a large muscle that lies on the side of the thigh.

Furthermore, researchers often choose it for biopsies because it is relatively accessible and provides a representative sample of skeletal muscle tissue.

Considerations

Pain and Bruising: After a muscle biopsy, especially an open biopsy, you may experience some pain, bruising, and soreness; consequently, these are common effects.

Scarring: Furthermore, the biopsy site will have a small scar once the procedure is complete.

Infection: Additionally, like any surgical procedure, the risk of infection exists.

Importance of Proper Technique

Sterile Technique: To minimize the risk of infection, medical professionals must strictly adhere to sterile techniques. Therefore, this practice is essential in maintaining patient safety.

Sample Size: Ensuring an adequate sample size is crucial for obtaining accurate analysis. Consequently, a larger sample size often leads to more reliable outcomes.

Muscle Fiber Orientation: The orientation of muscle fibers can significantly influence the biopsy results. As a result, understanding this aspect is vital for accurate interpretation.

Procedure for Muscle Biopsy

Following procedure is used for muscle biopsy.

  • Needle Biopsy:

    This is the most common method. First, a healthcare provider administers local anesthesia is administered to numb the area. Then, a needle is inserted through the skin and into the muscle to extract a small tissue sample. 

  • Open Biopsy:
    In contrast,  a surgeon makes a surgical incision to access the muscle and remove a larger tissue sample. Typically, this is usually done under local or general anesthesia

Risks

Muscle tissue: A biopsy can collect a sample of muscle tissue. However, the risks associated with a muscle tissue biopsy include bleeding, bruising, and infection at the procedure site.

Additionally, you may also develop a subfascial hematoma, which is a pocket of blood that forms beneath the fatty layer of skin next to the muscle.

Furthermore, if you have a medical condition or take medication or supplements that increase bleeding risk, you may face a higher chance of bleeding from the procedure site.

Moreover, less common risks include muscle contracture, which is the shortening of the muscle, and nerve damage that can lead to loss of sensation at or around the procedure site.

In addition, depending on the biopsy site and method used, other complications may arise. For instance, an open biopsy might require sedation, which carries its own risks.

Multiple Procedures

Consequently, the healthcare provider may need to perform the procedure more than once. Therefore, if you have any concerns about the risks of a muscle biopsy, it is advisable to discuss them with your healthcare worker.

Muscle biopsy requires a small incision through the skin and into the muscle to remove a sample of muscle tissue from the affected area.

However, while you may experience slight bruising or bleeding at the site, it is important to note that the risks associated with the procedure are minimal.

Vastus Lateralis Muscle Overview

The vastus lateralis muscle is located on the lateral side of the thigh.

This muscle is the largest of the quadriceps which includes: rectus femoris, vastus intermedius, and vastus medialis.

In fact, collectively, the quadriceps muscle is the largest in the human body and its purpose is to extend the knee.

Specifically, the vastus lateralis muscle extends the lower leg and allow the body to rise up from a squatting position.

However, it is essential to recognize that together, the quadriceps act on the knee and hip to promote movement as well as strength and stability.

Consequently, they provide power for and absorb the impact of daily activities such as walking, running, and jumping.

Additionally, on the upper end, the muscle attaches to the femur; on the lower end it attaches to the patella, or kneecap.

Furthermore, taken together, the muscles of the legs allow strength and stability. 

Summary

In summary, a vastus lateralis muscle biopsy serves as a valuable tool for investigating muscle health. However, on the other hand, it’s essential to recognize the potential risks and, moreover, ensure that the procedure is performed using proper techniques.

Biospecimens

Bay Biosciences is a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens, and human bio-fluid collections.

Samples available include cancer (tumor) tissue, cancer serum, cancer plasma, cancer, peripheral blood mononuclear cells (PBMC). and human tissue samples from most other therapeutic areas and diseases.

Bay Biosciences maintains and manages its own biorepository, the human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and from normal healthy donors available in all formats and types.

In fact, our biobank procures and stores fully consented, de-identified and institutional review boards (IRB) approved human tissue samples and matched controls.

Also, all our human tissue collections, human specimens and human bio-fluids are provided with detailed, samples associated patient’s clinical data.

So this critical patient’s clinical data includes information relating to their past and current disease. In addition, treatment history, lifestyle choices, biomarkers, and genetic information.

Furthermore, the patient’s data is extremely valuable for researchers and is used to help identify new effective treatments (drug discovery & development) in oncology, and other therapeutic areas and diseases.

Moreover, Bay Biosciences banks wide variety of human tissue samples and biological samples, including cryogenically preserved at – 80°C.

For instance, there are fresh frozen tissue samples, tumor tissue samples, formalin-fixed paraffin-embedded (FFPE), tissue slides, along with matching human bio-fluids, whole blood and blood-derived products such as serum, plasma and PBMC.

In addition, Bay Biosciences is a global leader in collecting and providing human tissue samples according to the specified requirements and customized, tailor-made collection protocols.

Please contact us anytime to discuss your special research projects and customized human tissue sample requirements.

Types of Biospecimens

Bay Biosciences provides human tissue samples (human specimens) from diseased and normal healthy donors which includes:

Moreover, we can also procure most human bio-specimens, special collections and requests for human samples that are difficult to find. All our human tissue samples are procured through IRB-approved clinical protocols and procedures.

In addition to the standard processing protocols, Bay Biosciences can also provide human plasma, serum, and PBMC bio-fluid samples using custom processing protocols; you buy donor-specific collections in higher volumes and specified sample aliquots from us.

Bay Biosciences also provides human samples from normal healthy donors; volunteers, for controls and clinical research, contact us Now.

  • 日本のお客様は、ベイバイオサイエンスジャパンBay Biosciences Japanまたはhttp://baybiosciences-jp.com/contact/までご連絡ください。