Bay Biosciences provides cryogenically frozen (-80) fresh frozen  high quality, clinical grade serum (sera), plasma and peripheral blood mononuclear cells (PBMC) biofluid samples from unique Chronic Nonspecific Interstitial Pneumonia (NSIP) pulmonary disease patients,

Moreover, detailed clinical info associated with the samples are provided to a valued customer for research.

What is Interstitial Lung Disease?

Interstitial lung disease (ILD) consists of a group of diffuse parenchymal lung disorders. Therefore, doctors classify according to their specific clinical, radiological, and histopathological features. Moreover, ILD’s are a large group of disorders, most of which cause progressive scarring of lung tissue.

Consequently, the scarring associated with interstitial lung disease affects the ability to breathe and get enough oxygen the bloodstream. For instance, long-term exposure to hazardous materials, such as asbestos, can cause interstitial lung disease (ILD).

Additionally, some types of autoimmune diseases, such as rheumatoid arthritis, can also cause interstitial lung disease. In some cases, however, the causes remain unknown.

Furthermore, once lung scarring occurs, it’s generally irreversible. Although** medications may slow the damage of interstitial lung disease (ILD), many people never regain full use of their lungs. Ultimately, lung transplant is an option for some patients who have interstitial lung disease (ILD).

Nonspecific Interstitial Pneumonia (NSIP) Overview

NSIP is a rare disorder that affects the tissue that surrounds and separates the tiny air sacs of the lungs. Specifically, these air sacs, called the alveoli, where the exchange of oxygen and carbon dioxide takes place between the lungs.

Consequently, with interstitial pneumonia, the mesh-like walls of the alveoli become inflamed. Furthermore, the pleura might become inflamed as well. As a result, over time, this inflammation can lead to permanent scarring of the lungs.

Multiple Conditions

In addition, NSIP appears in a number of different diseases, including connective tissue disorders. Reactions to certain medications, HIV, and other medical conditions. Moreover, some patients also have idiopathic NSIP, which means that the specific cause of the lung disease is unknown.

NSIP has only been defined for a relatively short time. Consequently, not much is known about how common it is versus other kinds of interstitial pneumonia.

Moreover, Caucasian patients account for most of the NSIP cases in the United States, with an average age of onset of the disease between the ages of 40 and 50 years. Furthermore, there does not seem to be a correlation between cigarette smoking and NSIP.

Types of Nonspecific Interstitial Pneumonia (NSIP)

Nonspecific interstitial pneumonia has only been defined for a relatively short time. Consequently, not much is known about how common it is versus other kinds of interstitial pneumonia.

Moreover, Caucasian patients account for most of the NSIP cases in the United States, with an average age of onset of the disease between the ages of 40 and 50 years. Furthermore, there does not seem to be a correlation between cigarette smoking and NSIP.

Signs and Symptoms of Nonspecific Interstitial Pneumonia (NSIP)

Following are the common signs and symptoms of nonspecific interstitial pneumonia (NSIP):

  • First, a dry cough
  • Additionally, shortness of breath which may occur after effort or become worse over time
  • Moreover, difficult or labored breathing
  • Furthermore, fatigue
  • Lastly, clubbing, or enlargement of the fingertips at the base of the nails. Clubbing may be present due to a lack of oxygen in the blood. Generally, this occurs in only about 10% of people with NSIP.

Causes of Nonspecific Interstitial Pneumonia (NSIP)

Causes of nonspecific interstitial pneumonia (NSIP) are unknown. Moreover, many researchers believe that it is an autoimmune disease, particularly because of the similarities between NSIP and certain connective tissue diseases, such as systemic sclerosis.

In addition, some researchers suggest that genes are involved, with heredity playing a role in its development. Furthermore, inhaling chemicals or dust, using certain chemotherapy drugs, or radiation treatment could result in the lung damage associated with NSIP.

Diagnosis of Nonspecific Interstitial Pneumonia (NSIP)

Because the symptoms of nonspecific interstitial pneumonia resemble those of other diseases, especially idiopathic pulmonary fibrosis (IPF), doctors, therefore, perform tests to rule out other related disorders. Moreover, the diagnosis of the disease depends on a combination of clinical, radiologic, and other factors.

In addition, doctors may perform pulmonary function tests to assess if the lungs are working properly and to evaluate the rate of carbon dioxide and oxygen exchange.

Generally, doctors subsequently perform a high-resolution computerized tomography (CT) scan to help diagnose NSIP. Specifically, CT scans of patients with NSIP show a typical “ground glass” pattern that represents interstitial inflammation; consequently, doctors usually see it in the cellular form. Furthermore, this pattern assists in differentiating NSIP from other interstitial lung diseases.

Bronchoscopy

The methods of obtaining tissue can be through a bronchoscopy or, alternatively, through a surgical procedure where a surgeon removes a portion of the lung. Specifically, a bronchoscopy uses a flexible tube called a bronchoscope that enters the bronchi (air passages) of the lung, and, subsequently, a medical professional passes a saline fluid through the bronchoscope.

After coming into contact with the airways and alveoli, the medical professional then aspirates (sucks out) the fluid and collects it for further analysis. This procedure is, in fact, called a bronchoalveolar lavage (BAL).

Moreover, elevated levels of lymphocytes (white blood cells) in the fluid have been detected in over half of patients with NSIP; however, this is not always specific to this disease. Furthermore, doctors may also take biopsies during the bronchoscopy to get a closer look at the lung tissue for inflammation or scarring. In many patients, therefore, a surgical lung biopsy may be necessary to make a definitive diagnosis.

Biospecimens

biospecimens

Bay Biosciences is a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens, and human bio-fluid collections.

Human biospecimens are available including cancer (tumor) tissue, cancer serum, cancer plasma, cancer peripheral blood mononuclear cells (PBMC). and human tissue samples from most other therapeutic areas and diseases.

Bay Biosciences maintains and manages its own biorepository, the human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and from normal healthy donors for controls, available in all formats and types.

In fact, our biobank procures and stores fully consented, de-identified and institutional review boards (IRB) approved human tissue samples, human biofluids such as serum samples, plasma samples from various diseases and matched controls.

Also, all our human tissue collections, human biospecimens and human biofluids are provided with detailed, samples associated patient’s clinical data.

In fact, this critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers, and genetic information.

Additionally, researchers find the patient’s data associated with the human biospecimens extremely valuable and use it to help identify new effective treatments (drug discovery & development) in oncology, as well as in other therapeutic areas and diseases.

Bay Biosciences banks wide variety of human tissue samples and human biological samples, including fresh frozen human biospecimens cryogenically preserved at – 80°C.

For example fresh frozen tissue samples, tumor tissue samples, formalin-fixed paraffin-embedded (FFPE), tissue slides, with matching human bio-fluids, whole blood and blood-derived products such as human serum, human plasma and human PBMCs.

Bay Biosciences is a global leader in collecting and providing human tissue samples according to the specified requirements and customized, tailor-made collection protocols.

Please contact us anytime to discuss your special research projects and customized human tissue sample requirements.

Types of Biospecimens

Bay Biosciences provides human tissue samples (human specimens) and human biofluids from diseased and normal healthy donors which includes:

Moreover, we can also procure most human biospecimens and human biofluids, special collections and requests for human samples that are difficult to find. All our human tissue samples and human biofluids are procured through IRB-approved clinical protocols and procedures.

In addition to the standard processing protocols, Bay Biosciences can also provide human biofluids such as  human plasma, human serum, and human PBMCs bio-fluid samples using custom processing protocols; you buy donor-specific collections in higher volumes and specified sample aliquots from us.

Bay Biosciences also provides human biospecimens from normal healthy donors; volunteers, for controls and clinical research, Contact us Now.