Bay Biosciences provides high quality, clinical grade bio-specimens, cryogenically preserved sera (serum), plasma and peripheral blood mononuclear cells (PBMC) biofluid samples from patients diagnosed with autoimmune diseases.
The sera (serum), plasma and PBMC biofluid specimens are processed from patient’s peripheral whole-blood using customized collection and processing protocols. The autoimmune disease bio-specimens are collected from unique patients diagnosed with autoimmune disease and are provided to a valued pharmaceutical customer for research, diagnostics, discovery and drug development.
Detailed clinical data, autoimmune disease patients history, symptoms, antinuclear antibody test (ANA), complete blood count (CBC), elevated biomarker levels, genetic and metabolic information, histopathological findings, annotations associated with autoimmune disease patient’s specimens is provided to a valued customer for research, development and drug discovery. The autoimmune disease sera (serum), plasma and peripheral blood mononuclear cells (PBMC) biofluid are processed from patients peripheral whole-blood using customized collection and processing protocols.
Autoimmune Disease Overview
An autoimmune disease is a condition in which the immune system mistakenly attacks the body. The immune system normally protects against germs like bacteria and viruses. When the immune system senses these foreign invaders, it sends out an army of fighter cells to attack and destroy them.
Normally, the immune system can tell the difference between foreign cells and the body’s own cells. In an autoimmune disease, the immune system mistakes part of your body, like your joints or skin, as foreign. It releases proteins called autoantibodies that attack healthy cells.
Some autoimmune diseases target only one organ. Type-1 Diabetes damages the pancreas. Other diseases, like systemic lupus erythematosus systemic lupus erythematosus (SLE), affect the whole body.
Exactly what causes the immune-system to misfire is unknown. Yet some people are more likely to get an autoimmune disease than others. According to a 2014 study, women get autoimmune diseases at a rate of about 2 to 1 compared to men, 6.4 percent of women vs. 2.7 percent of men. Often the autoimmune diseases starts during a woman’s childbearing years (ages 15 to 44). Some autoimmune diseases are more common in certain ethnic groups. For example, systemic lupus erythematosus (SLE) affects more African-Americans and Hispanics than Caucasians.
Certain autoimmune diseases, like multiple sclerosis and systemic lupus erythematosus (SLE), run in families. Not every family member will necessarily have the same disease, but they inherit a susceptibility to an autoimmune condition. Because the incidence of autoimmune diseases is rising, researchers suspect environmental factors like infections and exposure to chemicals or solvents might also be involved.
A “Western diet” is another suspected risk factor for developing an autoimmune disease. Eating high-fat, high-sugar, and highly processed foods is thought to be linked to inflammation, which might set off an immune response. However, this hasn’t been proven.
A 2015 study focused on another theory called the hygiene hypothesis. Because of vaccines and antiseptics, children today aren’t exposed to as many germs as they were in the past. The lack of exposure could make their immune system prone to overreact to harmless substances. Researchers don’t know exactly what causes autoimmune diseases. Genetics, diet, infections, and exposure to chemicals might be involved.
Autoimmune Disease Signs and Symptoms
Following are common signs and symptoms of many autoimmune diseases:
- Fatigue
- Fever (low-grade)
- Hair loss
- Muscle aches
- Swelling and redness
- Skin rashes
- Trouble concentrating
- Numbness and tingling in the hands and feet
Each autoimmune disease can also have its own unique symptoms. For example, type-1 diabetes causes extreme thirst, weight loss, and fatigue. Inflammatory Bowel Diseases (IBD) causes stomach pain, bloating, and diarrhea. With autoimmune diseases like psoriasis or rheumatoid arthritis (RA), symptoms may come and go. A period of symptoms is called a flare-up., and a period when the symptoms go away is called remission. Symptoms like fatigue, muscle aches, swelling, and redness could be signs of an autoimmune disease, symptoms might come and go over time.
Autoimmune Disease Diagnosis
There is no single test to diagnose most autoimmune diseases, combination of tests and a review of the symptoms and physical examination may be used to diagnose autoimmune diseases.
The antinuclear antibody test (ANA) is often one of the first tests performed when symptoms suggest an autoimmune disease. A positive test means you may have one of these diseases, but it won’t confirm exactly which autoimmune disease you have or if you have one for sure. Other tests look for specific autoantibodies produced in certain autoimmune diseases. Other nonspecific tests may also be performed to check for the inflammation the autoimmune diseases produce in the body.
Autoimmune Disease Treatment
Treatments can’t cure autoimmune diseases, but they can control the overactive immune response and bring down inflammation or at least reduce pain and inflammation. Drugs used to treat these conditions include:
- Nonsteroidal anti-inflammatory drugs (NSAID’s) such as ibuprofen (Motrin, Advil) and naproxen (Naprosyn)
- Immune suppressing drugs
Treatments are also available to relieve symptoms like pain, swelling, fatigue, and skin rashes. Eating a well-balanced diet and getting regular exercise may also help you feel better.
Bay Biosciences is a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens and human bio-fluid collections from cancer (tumor) tissue, cancer serum, cancer plasma cancer PBMC and human tissue samples from most other therapeutic areas and diseases.
Bay Biosciences maintains and manages it’s own bio-repository, human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and from normal healthy donors available in all formats and types. Our biobank procures and stores fully consented, deidentified and institutional review boards (IRB) approved human tissue samples and matched controls.
All our human human tissue collections, human specimens and human bio-fluids are provided with detailed samples associated patient’s clinical data. This critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers and genetic information. Patient’s data is extremely valuable for researchers and is used to help identify new effective treatments (drug discovery & development) in oncology, other therapeutic areas and diseases. This clinical information is critical to demonstrate their impact, monitor the safety of medicines, testing & diagnostics, and generate new knowledge about the causes of disease and illness.
Bay Biosciences banks wide variety of human tissue samples and biological samples including cryogenically preserved -80°C, fresh, fresh frozen tissue samples, tumor tissue samples, FFPE’s, tissue slides, with matching human bio-fluids, whole blood and blood derived products such as serum, plasma and PBMC’s.
Bay Biosciences is a global leader in collecting and providing human tissue samples according to the researchers specified requirements and customized, tailor made collection protocols. Please contact us anytime to discuss your special research projects and customized human tissue sample requirements.
Bay Biosciences provides human tissue samples (human specimens) from diseased and normal healthy donors; including peripheral whole-blood, amniotic fluid, bronchoalveolar lavage fluid (BAL), sputum, pleural effusion, cerebrospinal fluid (CSF), serum (sera), plasma, peripheral blood mononuclear cells (PBMC’s), saliva, Buffy coat, urine, stool samples, aqueous humor, vitreous humor, kidney stones, renal calculi, nephrolithiasis, urolithiasis and other bodily fluids from most diseases including cancer. We can also procure most human bio-specimens and can do special collections and requests of human samples that are difficult to find. All our human tissue samples are procured through IRB approved clinical protocols and procedures.
In addition to the standard processing protocols Bay Biosciences can also provide human plasma, serum, PBMC bio-fluid samples using custom processing protocols, you can buy donor specific sample collections in higher volumes and specified sample aliquoting from us. Bay Biosciences also provides human samples from normal healthy donors, volunteers, for controls and clinical research, contact us Now.
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