Bay Biosciences provides fresh frozen tumor tissue samples with matching (-80°) serum, plasma, peripheral blood mononuclear cells (PBMC) biofluid samples from unique High-grade serous ovarian cancer patients.

High-grade serous ovarian cancer (HGSC) Overview

High-grade serous carcinoma (HGSC) originates from the serous epithelial layer in the abdominopelvic cavity and mainly occurs in the ovary. Consequently, HGSCs constitute the majority of ovarian cancer cases and exhibit the lowest survival rates.

Moreover, high-grade serous cancers represent the most deadly form of ovarian cancer and account for up to 70 percent of ovarian cancer cases. In fact, in most patients, doctors diagnose ovarian cancer when the disease progresses to an advanced stage, corresponding to stages IIb to IV, involving the peritoneal cavity and other organs.

As a result, advanced stages are diagnosed in most cases of HGSOC, and a significantly worse outcome is experienced by these patients than by those with early stage disease. Interestingly, it has been found that the majority of high grade serous ovarian cancers originate in the fallopian tube, not the ovary.

BRCA Mutation in High-grade serous carcinoma (HGSC)

Typically, the growth of cancer cells is normally controlled by the BRCA Mutation in High-grade serous carcinoma (HGSC), Breast cancer gene 1 (BRCA1), and breast cancer gene 2 (BRCA2). Furthermore, the risk for breast cancer is increased by mutations in these genes, which can be inherited from either parent to the child.

“Overall, the BRCA1 mutation increases the risk for ovarian cancer more than the BRCA2 mutation. Specifically, women with the BRCA1 mutation are more likely to develop ovarian cancer before they turn 50 years old. In contrast, women with the BRCA2 mutation are more likely to develop the disease after they turn 60 years old. Furthermore, doctors usually diagnose ovarian cancer at a younger age in women who do not have a BRCA gene mutation.

Moreover, ovarian cancer is likely linked to an inherited BRCA1 or BRCA2 gene mutation if the woman has:

  • Several family members with breast or ovarian cancer;
  • One or more female relatives who developed breast cancer before they were 50 years of age;
  • A relative with both breast and ovarian cancer;
  • Family members who develop cancer in both breasts (called bilateral breast cancer);
  • A male relative with breast cancer;
  • Ashkenazi (Eastern European) Jewish ancestry.

Researchers commonly link serous carcinoma (a type of epithelial ovarian carcinoma) to BRCA gene mutations more than to other types of ovarian cancer.

Furthermore, having ovarian cancer linked to a BRCA gene mutation also increases the risk of developing papillary serous carcinoma of the peritoneum, which is a cancer in the lining of the abdominal cavity.

Additionally, women with ovarian cancer related to a BRCA gene mutation also face a higher than average risk of developing breast and other cancers. Consequently, physicians usually provide women diagnosed with high-grade serous ovarian cancer with genetic counseling and testing for a specific genetic mutation BRCA 1 & 2.

Moreover, researchers link the BRCA gene mutation to high grade serous pelvic cancers and breast cancer.

Signs and Symptoms of High-grade serous ovarian cancer (HGSC)

Following are the signs or symptoms of ovarian cancer include:

  • Firstly, women may experience abnormal vaginal bleeding (such as heavy or irregular bleeding, bleeding between periods), especially after menopause.
  • Additionally, they may notice frequent vaginal discharge that is clear, white, or colored with blood.
  • Furthermore, they might feel a lump in the pelvis or abdomen.
  • Moreover, women may face bladder problems such as the frequent need to urinate and the urgent need to urinate.
  • In addition, they might encounter constipation
  • Furthermore, changes to digestion may occur, such as feeling full after a small meal, loss of appetite, heartburn, gas, indigestion, or nausea 
  •  In some cases, diarrhea may also occur.
  • Moreover, women may frequently feel pressure in the pelvis or abdomen
  • Alongside these symptoms, they may experience fatigue.
  • Additionally, pain in the legs, lower back, pelvis, or abdomen may be present.
  • Furthermore, women may experience pain when having sex.
  • Moreover, swelling of the abdomen may occur, and unexplained weight loss may also be a concern
  • In some instances, there may be a buildup of fluid in the abdomen (ascites), around the lungs (pleural effusion), or in the legs (lymphedema).Consequently, women may experience difficulty breathing, along with headaches.
  • Lastly, fever may also be observed.

Biospecimens

Bay Biosciences is, indeed a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens, and human bio-fluid collections.

Specifically, aamples available include cancer (tumor) tissue, cancer serum, cancer plasma, cancer, peripheral blood mononuclear cells (PBMC). and human tissue samples from most other therapeutic areas and diseases.

Moreover, Bay Biosciences maintains and manages its own biorepository, the human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and from normal healthy donors available in all formats and types.

In fact, our biobank procures and stores fully consented, de-identified and institutional review boards (IRB) approved human tissue samples and matched controls.

Additionally, all our human tissue collections, human specimens and human bio-fluids are provided with detailed, samples associated patient’s clinical data.

In particular, critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers, and genetic information.

Moreover, patient’s data is extremely valuable for researchers and is used to help identify new effective treatments (drug discovery & development) in oncology, and other therapeutic areas and diseases.

Specifically, Bay Biosciences banks wide variety of human tissue samples and biological samples, including cryogenically preserved at – 80°C.

For example fresh frozen tissue samples, tumor tissue samples, formalin-fixed paraffin-embedded (FFPE), tissue slides, with matching human bio-fluids, whole blood and blood-derived products such as serum, plasma and PBMC.

Furthermore, Bay Biosciences is a global leader in collecting and providing human tissue samples according to the specified requirements and customized, tailor-made collection protocols.

Therefore, please contact us anytime to discuss your special research projects and customized human tissue sample requirements.

Types of Biospecimens

Bay Biosciences provides human tissue samples (human specimens) from diseased and normal healthy donors which includes:

Customized Collections

Moreover, we can also procure most human bio-specimens, furthermore; we offer special collections and requests for human samples that are difficult to find. All our human tissue samples are procured through IRB-approved clinical protocols and procedures.

In addition to the standard processing protocols, Bay Biosciences can also provide human plasma, serum, and PBMC bio-fluid samples using custom processing protocols. Additionally you buy donor-specific collections in higher volumes and specified sample aliquots from us.

Furthermore, Bay Biosciences also provides human samples from normal healthy donors; volunteers, for controls and clinical research, contact us Now.

 

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