Bay Biosciences provides high quality, clinical grade bio-samples, sera (serum), plasma and peripheral blood mononuclear cells (PBMC) biofluid specimens from patients diagnosed with cerebral lupus. Moreover, the serum, plasma and PBMC samples are processed from patient’s peripheral whole-blood using customized processing protocols.

Furthermore, the samples are collected from unique patients diagnosed with cerebral lupus and are provided to a valued pharmaceutical customer for research, development and drug discovery.

In addition, detailed clinical information associated with cerebral lupus specimens is provided to a valued customer for research, development and drug discovery.

Cerebral Lupus Overview

Lupus can affect both the central nervous system (the brain and spinal cord) and the peripheral nervous system.

Specifically, lupus may attack the nervous system via antibodies that bind to nerve cells or the blood vessels that feed them; alternatively, it may do so by interrupting the blood flow to nerves.

Cognitive Dysfunction

Moreover, the most common manifestation of neuro-lupus is cognitive dysfunction, which is characterized by clouded thinking, confusion, and impaired memory. In fact, eighty percent of lupus patients who have had lupus for ten years or more will experience this condition.

Furthermore, single positron emission computed tomography (SPECT) scans of SLE patients with cognitive dysfunction show abnormalities in blood flow, indicating that the condition may be the result of decreased oxygen delivery to certain parts of the brain.

Unfortunately, there is no real treatment for cognitive dysfunction. Nevertheless, it normally does not get worse over time. However, some people find that counseling and other forms of cognitive therapy help them to cope with associated symptoms.

Symptoms

Cerebral lupus  can affect your central, peripheral, and autonomic nervous systems. Consequently, many possible NPSLE symptoms exist.

Furthermore, the American College of Rheumatology developed a  list of syndromes with links to NPSLE. According to a 2019 review, the most common NPSLE syndromes include:

Causes

It’s not clear what causes NPSLE; however, as with lupus, experts believe that immune system dysfunction plays a role.

Moreover, researchers have identified several immune system components that are likely to contribute to the development of NPSLE, including:

  • Autoantibodies
  • Cell-mediated inflammation
  • Cytokines

Diagnosis

On one hand, it can be hard to know for sure whether nervous system symptoms are due to lupus or another condition. To diagnose NPSLE, your doctor will try to rule out other possible explanations for your symptoms.

Moreover, there are no standardized diagnostic criteria for NPSLE; however, doctors typically look for neuropsychiatric symptoms that appear alongside other signs of SLE, such as skin lesions, inflammation, and immune system activation.

Initially, they’ll start by asking you about your symptoms, any medications you take, and your medical and family history. After that, they’ll conduct a thorough physical examination.

Depending on their findings, they may, in fact, order other tests. These might include:

  • Biopsies
  • Blood tests
  • Brain scans (CT or MRI)
  • Cerebrospinal fluid tests
  • Electroencephalogram
  • Urine tests.

Treatment

In addition, NPSLE can look very different from one person to the next. As a result, there’s no standardized treatment for it. Consequently, doctors typically prescribe SLE treatments alongside other symptom-specific medications.

Outlook

Furthermore, people with NPSLE have a higher risk of death compared with people with SLE. Additionally, some research also links severe NPSLE symptoms to a lower chance of survival.

For instance, according to a 2020 study, the mortality rate among people with mild to severe NPSLE was four to five times higher than that of the larger population.

Biospecimens

biospecimens

Bay Biosciences is a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens, and human bio-fluid collections.

Moreover, human biospecimens are available including tumor tissue, serum, plasma and PBMC Samples from most other therapeutic areas.

Furthermore, Bay Biosciences maintains and manages its own biorepository, the human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and likewise normal healthy donors for controls. Additionally, available in all formats and types.

In fact, our biobank procures and stores fully consented, de-identified and institutional review boards (IRB) approved human tissue samples, human biofluids such as serum samples, plasma samples from various diseases and matched controls.

Also, all our human tissue collections, human biospecimens and human biofluids are provided with detailed, samples associated patient’s clinical data.

In fact, this critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers, and genetic information.

Additionally, researchers find the patient’s data associated with the human biospecimens extremely valuable and use it to help identify new effective treatments (drug discovery & development) in oncology, as well as in other therapeutic areas and diseases.

Bay Biosciences banks wide variety of human tissue samples and human biological samples, including fresh frozen human biospecimens cryogenically preserved at – 80°C.

For example fresh frozen tissue samples, tumor tissue samples, formalin-fixed paraffin-embedded (FFPE), tissue slides, with matching human bio-fluids, whole blood and blood-derived products such as human serum, human plasma and human PBMCs.

Bay Biosciences is a global leader in collecting and providing human tissue samples according to the specified requirements and customized, tailor-made collection protocols.

Please contact us anytime to discuss your special research projects and customized human tissue sample requirements.

Types of Biospecimens

Bay Biosciences provides human tissue samples (human specimens) and human biofluids from diseased and normal healthy donors which includes:

Moreover, we can also procure most human biospecimens and human biofluids, special collections and requests for human samples that are difficult to find. All our human tissue samples and human biofluids are procured through IRB-approved clinical protocols and procedures.

In addition to the standard processing protocols, Bay Biosciences can also provide human biofluids such as  human plasma, human serum, and human PBMCs bio-fluid samples using custom processing protocols. you buy donor-specific collections in higher volumes and specified sample aliquots from us in multiple format and sets.

Bay Biosciences also provides human biospecimens from normal healthy donors; volunteers, for controls and clinical research, Contact us Now.