Bay Biosciences provides high quality, clinical grade bio-samples, sera (serum), plasma and peripheral blood mononuclear cells (PBMC) biofluid specimens from patients diagnosed with cystic fibrosis. The serum, plasma and PBMCs are processed from patient’s peripheral whole-blood using customized processing protocols.

Moreover, the bio fluids samples are processed from CF patient’s whole-blood using customized collection and processing protocols.

Furthermore, the samples are collected from unique patients diagnosed with CF. And and are provided to a valued pharmaceutical customer for research, discovery and drug development.

In addition, clinical information associated with CF specimens is provided to a valued customer for research, development and drug discovery.

Cystic Fibrosis (CF) Disease Overview

In fact, cystic fibrosis (CF) is an inherited disorder that causes severe damage to the lungs. And digestive system, and other organs in the body. Specifically, cystic fibrosis affects the cells that produce mucus, sweat, and digestive juices.

These secreted fluids are normally thin and slippery; however, in patients with Cystic Fibrosis, a defective gene causes the secretions to become sticky and thick.

Consequently, instead of acting as lubricants, the secretions plug up tubes, ducts, and passageways, especially in the lungs and pancreas.

Although cystic fibrosis is progressive and requires daily care, patients with Cystic Fibrosis are usually able to attend school and work. In fact, they often have a better quality of life than patients with Cystic Fibrosis had in previous decades. Furthermore, improvements in screening and treatments mean that patients with Cystic Fibrosis now may live into their mid- to late 30s or 40s, and some are even living into their 50s.

Cystic Fibrosis Symptoms

In the United States because of newborn screening, cystic fibrosis can be diagnosed within the first month of life, before symptoms develop. But Cystic Fibrosis patients born before newborn screening became available may not receive a diagnosis until the signs and symptoms of Cystic Fibrosis disease show up.

Cystic fibrosis signs and symptoms vary, depending on the severity of the disease. Even in the same person, symptoms may worsen or improve as time passes. Some patients may not experience symptoms until their teenage years or adulthood. Patients who are not diagnosed until adulthood usually have milder disease and are more likely to have atypical symptoms, such as recurring bouts of an inflamed pancreas (pancreatitis), infertility and recurring pneumonia. Patients with cystic fibrosis have a higher than normal level of salt in their sweat. Parents often can taste the salt when they kiss their children. Most of the other signs and symptoms of Cystic Fibrosis affect the respiratory system and digestive system.

Cystic Fibrosis Causes

In Cystic Fibrosis (CF) disease, a defect (mutations) in a gene, specifically the cystic fibrosis transmembrane conductance regulator (CFTR) gene, changes a protein that regulates the movement of salt in and out of cells. As a result, there is thick, sticky mucus in the respiratory, digestive, and reproductive systems, as well as increased salt in sweat.

Moreover, many different defects can occur in the gene. Notably, the type of gene mutation is associated with the severity of the condition. Consequently, children need to inherit one copy of the gene from each parent in order to have the disease. If, however, children inherit only one copy, they won’t develop cystic fibrosis. Nevertheless, they will be carriers and could pass the gene to their own children.

Cystic Fibrosis Disease Risk Factors

Because cystic fibrosis disease is an inherited disorder, it runs in families, so family history is a risk factor. Although Cystic Fibrosis disease occurs in all races, it’s most common in white people of Northern European ancestry.

Cystic Fibrosis Diagnosis

Cystic fibrosis diagnosis requires clinical symptoms consistent with cystic fibrosis in at least one organ system and evidence of CFTR dysfunction usually based on an abnormal sweat chloride test or the presence of mutations in the CFTR gene. 

Some healthcare providers may perform the following diagnostic tests for the diagnosis of cystic fibrosis disease:

Immuno-reactive Trypsinogen (IRT) Test

The immuno-reactive trypsinogen (IRT) test is a standard newborn screening test that checks for abnormal levels of the protein called IRT in the blood. A high level of IRT may be a sign of cystic fibrosis. However, further testing is required to confirm the diagnosis.

Sweat Chloride Test

Sweat chloride test checks for increased levels of salt in the sweat, it is the most commonly used test for diagnosing cystic fibrosis. Researchers perform the test by using a chemical that makes the skin sweat when triggered by a weak electric current. They collect patients’ sweat on a pad or paper and then analyze it in a lab. Doctors make a diagnosis of cystic fibrosis if the sweat is saltier than normal.

Sputum Test

During a sputum test a sample of mucus is taken which can can confirm the presence of a lung infection. Sputum test can also show the types of germs that are present and determine which antibiotics work best to treat them.

Chest X-ray

A chest X-ray is useful in revealing swelling in the lungs due to blockages in the respiratory passageways.

CT Scan

CT scan creates detailed images of the body by using a combination of X-rays taken from many different directions. These images allows your doctor to view internal structures, such as the liver and pancreas, making it easier to assess the extent of organ damage caused by cystic fibrosis.

Pulmonary function tests (PFTs)

Pulmonary function tests (PFTs) determine whether the lungs are working properly. The tests can help measure how much air can be inhaled or exhaled and how well the lungs transport oxygen to the rest of the body. Any abnormalities in these functions may indicate cystic fibrosis.

Biospecimens

biospecimens

Bay Biosciences is a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens, and human bio-fluid collections.

Moreover, human biospecimens are available including tumor tissue, serum, plasma and PBMC Samples from most other therapeutic areas.

Furthermore, Bay Biosciences maintains and manages its own biorepository, the human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and likewise normal healthy donors for controls. Additionally, available in all formats and types.

In fact, our biobank procures and stores fully consented, de-identified and institutional review boards (IRB) approved human tissue samples, human biofluids such as serum samples, plasma samples from various diseases and matched controls.

Also, all our human tissue collections, human biospecimens and human biofluids are provided with detailed, samples associated patient’s clinical data.

In fact, this critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers, and genetic information.

Additionally, researchers find the patient’s data associated with the human biospecimens extremely valuable and use it to help identify new effective treatments (drug discovery & development) in oncology, as well as in other therapeutic areas and diseases.

Bay Biosciences banks wide variety of human tissue samples and human biological samples, including fresh frozen human biospecimens cryogenically preserved at – 80°C.

For example fresh frozen tissue samples, tumor tissue samples, formalin-fixed paraffin-embedded (FFPE), tissue slides, with matching human bio-fluids, whole blood and blood-derived products such as human serum, human plasma and human PBMCs.

Bay Biosciences is a global leader in collecting and providing human tissue samples according to the specified requirements and customized, tailor-made collection protocols.

Please contact us anytime to discuss your special research projects and customized human tissue sample requirements.

Types of Biospecimens

Bay Biosciences provides human tissue samples (human specimens) and human biofluids from diseased and normal healthy donors which includes:

Moreover, we can also procure most human biospecimens and human biofluids, special collections and requests for human samples that are difficult to find. All our human tissue samples and human biofluids are procured through IRB-approved clinical protocols and procedures.

In addition to the standard processing protocols, Bay Biosciences can also provide human biofluids such as  human plasma, human serum, and human PBMCs bio-fluid samples using custom processing protocols. you buy donor-specific collections in higher volumes and specified sample aliquots from us in multiple format and sets.

Bay Biosciences also provides human biospecimens from normal healthy donors; volunteers, for controls and clinical research, Contact us Now.