Bay Biosciences provides high quality, clinical grade bio-samples, sera (serum), plasma and peripheral blood mononuclear cells (PBMC) biofluid specimens from patients diagnosed with Glaucoma.

The sera (serum), plasma and PBMC biofluid specimens are processed from Glaucoma patient’s peripheral whole-blood using customized collection and processing protocols.

The Glaucoma matched biofluid samples are collected from unique patients diagnosed with Glaucoma and are provided to a valued pharmaceutical customer for research, diagnostics, discovery and drug development.

Detailed clinical data, Glaucoma patient’s history, symptoms, complete blood count (CBC), serology, eye exams, histopathology, elevated biomarker data associated with Glaucoma specimens is provided to a valued customer for research, development and drug discovery.

The Glaucoma sera (serum), plasma and peripheral blood mononuclear cells (PBMC) biofluids are processed from patients peripheral whole-blood using customized collection and processing. protocols.

Glaucoma Overview

Glaucoma is a disease that damages your eye’s optic nerve. It usually occurs when fluid builds up in the front part of the eye. That excess fluid increases the pressure in the eye, damaging the optic nerve. It gets worse over time and tends to run in families.

The increased pressure in the eye, called intraocular pressure, can damage the optic nerve, which sends images to the brain. If the damage worsens, glaucoma can cause permanent vision loss or even total blindness within a few years.

Causes of Glaucoma

The eyes continuously makes a transparent water like fluid inside the eyes, similar to plasma, called aqueous humor, which It is secreted from the ciliary body, a structure supporting the lens of the eyeball.

Aqueous humor usually flows out of the eyes through a mesh-like channel. If this channel gets blocked, or the eye is producing too much fluid, the liquid builds up. The pressure inside the eye rises, damaging the optic nerve.

Other less common causes of glaucoma include a blunt or chemical injury to the eye, severe eye infection, blocked blood vessels inside the eye, and inflammatory conditions. Sometimes eye surgery to correct another condition can also cause glaucoma. This usually affects both eyes, but it may be worse in one eye than the other.

Types of Glaucoma

Following are the are two main types of Glaucoma:

Open-angle glaucoma: This is the most common type of glaucoma. It happens gradually, when the eye does not drain fluid as well as it normally should. As a result, eye pressure builds and starts to damage the optic nerve. This type of glaucoma is painless and causes no vision changes at first.
Angle-closure glaucoma: This type happens when someone’s iris is very close to the drainage angle in their eye. The iris  can end up blocking the drainage angle.  The eye doesn’t drain like it should because the drain space between the iris and cornea becomes too narrow. This can cause a sudden buildup of pressure in the eye. It’s also linked to farsightedness and cataracts in the eyes which can cloud the lens inside the eye.

Following are the other less common types of glaucoma:

  • Secondary glaucoma: This is when another disease, like cataracts or diabetes, causes added pressure in the eye.
  • Normal-tension glaucoma: This is when you have blind spots in your vision or your optic nerve is damaged even though your eye pressure is within the average range.
  • Pigmentary glaucoma: With this form, tiny bits of pigment from the iris, the colored part of the eye, get into the fluid inside the eye and clog the drainage canals.

Signs and Symptoms of Glaucoma

Most patients with open-angle glaucoma don’t have symptoms. Usually the symptoms develop late in the disease, if they develop. The main sign is usually a loss of side, or peripheral, vision.

Symptoms of angle-closure glaucoma usually come on faster and are more obvious. Damage can happen quickly. Following are some of the signs and symptoms of angle-closure glaucoma:

  • Eye pain
  • Eye that looks hazy
  • Redness in the eye
  • Upset stomach or vomiting
  • Seeing halos around lights
  • Vision loss

Biospecimens

biospecimens

Bay Biosciences is a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens, and human bio-fluid collections.

Moreover, human biospecimens are available including tumor tissue, serum, plasma and PBMC Samples from most other therapeutic areas.

Furthermore, Bay Biosciences maintains and manages its own biorepository, the human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and likewise normal healthy donors for controls. Additionally, available in all formats and types.

In fact, our biobank procures and stores fully consented, de-identified and institutional review boards (IRB) approved human tissue samples, human biofluids such as serum samples, plasma samples from various diseases and matched controls.

Also, all our human tissue collections, human biospecimens and human biofluids are provided with detailed, samples associated patient’s clinical data.

In fact, this critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers, and genetic information.

Additionally, researchers find the patient’s data associated with the human biospecimens extremely valuable and use it to help identify new effective treatments (drug discovery & development) in oncology, as well as in other therapeutic areas and diseases.

Bay Biosciences banks wide variety of human tissue samples and human biological samples, including fresh frozen human biospecimens cryogenically preserved at – 80°C.

For example fresh frozen tissue samples, tumor tissue samples, formalin-fixed paraffin-embedded (FFPE), tissue slides, with matching human bio-fluids, whole blood and blood-derived products such as human serum, human plasma and human PBMCs.

Bay Biosciences is a global leader in collecting and providing human tissue samples according to the specified requirements and customized, tailor-made collection protocols.

Please contact us anytime to discuss your special research projects and customized human tissue sample requirements.

Types of Biospecimens

Bay Biosciences provides human tissue samples (human specimens) and human bio-fluids from diseased and normal healthy donors which includes:

  • Firstly, peripheral whole-blood
  • Secondly, amniotic fluid
  • Thirdly, bronchoalveolar lavage fluid (BAL)
  • Next, sputum
  • Also, pleural effusion
  • Moreover, cerebrospinal fluid (CSF)
  • Likewise, serum (sera)
  • In addition, plasma
  • Moreover, peripheral blood mononuclear cells (PBMC) 
  • Furthermore, saliva
  • Next, buffy coat
  • Accordingly, urine
  • For example, Stool samples
  • Also, aqueous humor
  • And, vitreous humor
  • Lastly, kidney stones (renal calculi)
  • Finally, other bodily fluids from most diseases including cancer.

Moreover, we can also procure most human biospecimens and human biofluids, special collections and requests for human samples that are difficult to find. All our human tissue samples and human biofluids are procured through IRB-approved clinical protocols and procedures.

In addition to the standard processing protocols, Bay Biosciences can also provide human biofluids such as  human plasma, human serum, and human PBMCs bio-fluid samples using custom processing protocols. you buy donor-specific collections in higher volumes and specified sample aliquots from us in multiple format and sets.

Bay Biosciences also provides human biospecimens from normal healthy donors; volunteers, for controls and clinical research, Contact us Now.