Bay Biosciences provides high quality, clinical grade bio-samples, sera (serum), plasma and peripheral blood mononuclear cells (PBMC) bio-fluid specimens from patients diagnosed with Type-I Diabetes disease. The PBMC, sera (serum) and plasma samples are processed from patient’s peripheral whole-blood using customized processing protocols.
The human diabetes bio-specimens are collected from unique patients suffering from Type-I diabetes disease and provided to a valued pharmaceutical customer for genomics, proteomics and biomarker research, development and drug discovery.
Diabetes
Diabetes mellitus, commonly known as diabetes, is a metabolic disorder that causes high blood sugar. The hormone insulin moves sugar from the blood into the cells to be stored or used for energy. With diabetes, the body either doesn’t make enough insulin or can’t effectively use the insulin it does make. Untreated high blood sugar from diabetes can damage the nerves, eyes, kidneys, and other organs.
Types of Diabetes
There are a several different types of diabetes:
- Type-1 Diabetes is an autoimmune disease. The immune system attacks and destroys cells in the pancreas, where insulin is made. It’s unclear what causes this attack. Usually, the body’s own immune system, which normally fights harmful bacteria and viruses, mistakenly destroys the insulin-producing (islet, or islets of Langerhans) cells in the pancreas. Other possible causes include genetics and exposure to viruses and other environmental factors.
Type-1 diabetes is an insulin-dependent diabetes, it is a chronic condition in which the pancreas produces little or no insulin. Insulin is a hormone needed to allow sugar (glucose) to enter cells to produce energy.
- Type-2 Diabetes occurs when the body becomes resistant to insulin, and sugar builds up in the blood.
- Pre-Diabetes occurs when your blood sugar is higher than normal, but it’s not high enough for a diagnosis of type-2 diabetes.
- Gestational Diabetes is high blood sugar during pregnancy. Insulin-blocking hormones produced by the placenta cause this type of diabetes.
Symptoms
Diabetes signs and symptoms can appear relatively suddenly and may include:
- Increased thirst
- Frequent urination
- Bed-wetting in children who previously didn’t wet the bed during the night
- Extreme hunger
- Unintended weight loss
- Irritability and other mood changes
- Fatigue and weakness
- Blurred vision
The role of Insulin
Once a significant number of islet cells are destroyed, the body produce little or no insulin. Insulin is a hormone that comes from a gland situated behind and below the stomach (pancreas).
- The pancreas secretes insulin into the bloodstream.
- Insulin circulates, allowing sugar to enter your cells.
- Insulin lowers the amount of sugar in your bloodstream.
- As your blood sugar level drops, so does the secretion of insulin from your pancreas.
The role of glucose
Glucose, a sugar is a main source of energy for the cells that make up muscles and other tissues.
- Glucose comes from two major sources, food and the liver.
- Sugar is absorbed into the bloodstream, where it enters cells with the help of insulin.
- The liver stores glucose as glycogen.
- When the glucose levels are low, such as when you haven’t eaten in a while, the liver breaks down the stored glycogen into glucose to keep your glucose levels within a normal range.
In Type-1 Diabetes, there’s no insulin to let glucose into the cells, so sugar builds up in the bloodstream. This can cause life-threatening complications.
Detailed clinical data, elevated levels of antibodies, serology, biomarkers, HLA DR-DQ, IAA, IA2, ZnT8A, genetic info, pathology annotations, associated with the Type-1 Diabetes patient’s specimens is provided to a valued customer for drug discovery, development and research. The Type-1 Diabetes disease PBMC’s, sera and plasma samples were processed from patients peripheral blood using customized processing protocols provided by the researcher.
Bay Biosciences is a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens and human bio-fluid collections from cancer (tumor) tissue, cancer sera (serum), cancer plasma, cancer PBMC and human tissue samples from most other therapeutic areas and diseases.
Bay Biosciences maintains and manages it’s own bio-repository, human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and from normal healthy donors available in all formats and types. Our biobank procures and stores fully consented, deidentified and institutional review boards (IRB) approved human tissue samples and matched controls.
All our human human tissue collections, human specimens and human bio-fluids are provided with detailed samples associated patient’s clinical data. This critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers and genetic information. Patient’s data is extremely valuable for researchers and is used to help identify new effective treatments (drug discovery & development) in oncology, other therapeutic areas and diseases. This clinical information is critical to demonstrate their impact, monitor the safety of medicines, testing & diagnostics, and generate new knowledge about the causes of disease and illness.
Bay Biosciences banks wide variety of human tissue samples and biological samples including cryogenically preserved -80°C, fresh, fresh frozen tissue samples, tumor tissue samples, FFPE’s, tissue slides, with matching human bio-fluids, whole blood and blood derived products such as serum, plasma and PBMC’s.
Bay Biosciences is a global leader in collecting and providing human tissue samples according to the researchers specified requirements and customized, tailor made collection protocols. Please contact us anytime to discuss your special research projects and customized human tissue sample requirements.
Bay Biosciences provides human tissue samples (human specimens) from diseased and normal healthy donors; including peripheral whole-blood, amniotic fluid, bronchoalveolar lavage fluid (BAL), sputum, pleural effusion, cerebrospinal fluid (CSF), serum (sera), plasma, peripheral blood mononuclear cells (PBMC’s), saliva, Buffy coat, urine, stool samples, aqueous humor, vitreous humor, kidney stones, renal calculi, nephrolithiasis, urolithiasis and other bodily fluids from most diseases including cancer. We can also procure most human bio-specimens and can do special collections and requests of human samples that are difficult to find. All our human tissue samples are procured through IRB approved clinical protocols and procedures.
In addition to the standard processing protocols Bay Biosciences can also provide human plasma, serum, PBMC bio-fluid samples using custom processing protocols, you can buy donor specific sample collections in higher volumes and specified sample aliquoting from us. Bay Biosciences also provides human samples from normal healthy donors, volunteers, for controls and clinical research, contact us Now.
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