Bay Biosciences provides high quality, clinical grade, cryogenically preserved tumor tissue samples with matched K2EDTA plasma, sera (serum) and peripheral blood mononuclear cells (PBMC), bio-fluid samples from cutaneous B-Cell lymphoma patients.

The K2EDTA plasma, sera (serum) and PBMC bio-fluid specimens are processed from Cutaneous B-Cell Lymphoma patient’s peripheral whole-blood using customized collection and processing protocols.

Cutaneous B-Cell Lymphoma Overview

Cutaneous B-cell lymphoma (CBCL) is a type of non-Hodgkin’s lymphoma. This is a rare type of cancer that begins in the white blood cells. This cancer attacks the skin and causes lesions that look like a rash or bumps.. Cutaneous B-cell lymphoma starts in one type of germ-fighting white blood cell called B cells. These cells are also called B lymphocytes.

Treatment ranges from “watch and wait” to radiation, chemotherapy or surgical removal. Most cases of CBCL grow slowly and rarely affect other parts of your body, but some types can spread.

Doctors don’t understand what causes CBCL, but it’s not inherited or contagious. They do know that it starts in white blood cells called lymphocytes, part of your immune system.

Lymphocytes can be classified as T cells or B cells. This type of lymphoma involves B cells growing out of control. Most cases of CBCL can be treated and cured, but the condition may come back (recur).

Types of B-Cell Lymphoma

Following are the types of cutaneous B-cell lymphoma include:

Cutaneous B-cell lymphoma symptoms include a firm bump under the skin. The bump might be the same color as your skin. Or it might be a darker color or look pink or purple.

Anyone can develop CBCL. It’s known to occur in all genders/sexes and age groups, and many racial backgrounds. BCL is rare, affecting only about 4 of every 1 million people.

Stages of Cutaneous B-Cell Lymphoma

CBCL stage describes whether the cancer has spread and how much. The stage is important because it guides treatment decisions. Your healthcare provider will explain what stage the cancer is in and what it means for you.

Stage 1E (for extranodal) affects only your skin and hasn’t spread anywhere else. It may also be called stage 1AE if you have no additional “B” symptoms, such as weight loss.

If CBCL has spread, Doctors use the TNM staging system for diagnosis:

  • Tumor: “T” documents the number of papules, nodules or tumors, how big they are and where they are. The numbered scale ranges from less to more serious (1 to 3).
  • Nodes: “N” indicates whether lymph nodes are involved, how many and where they are. The scale ranges from less to more serious (0 to 3).
  • Metastasis: “M” refers to whether lymphoma has metastasized (spread) beyond your skin or lymph nodes (M1) or not spread (M0).

Other staging criteria include:

Bulky vs. Nonbulky

Bulky cancer means that a person has large cancer tumors in their chest. This type of lymphoma demands more aggressive treatment.

Addition of E

Cancers in stage 1 or 2 that also affect an organ outside of the lymphatic system may require more aggressive treatment. Doctors add an E for “extranodal organ” to indicate this stage, e.g., stage 2E.

Binet Staging System

Doctors use slightly different staging systems for small lymphocytic lymphoma and chronic lymphocytic leukemia. One system is the Binet staging system:

  • Stage A: There are fewer than three affected areas of lymphoid tissue, and the person does not have thrombocytopenia or anemia.
  • Stage B: The person has three or more enlarged areas of lymphoid tissue but has neither thrombocytopenia nor anemia.
  • Stage C: The person has either anemia or thrombocytopenia with any number of affected lymphoid tissue areas.


Signs and Symptoms of Cutaneous B-Cell Lymphoma

CBCL causes a rash, lump, bump, nodule or tumor on your skin (often called lesions). They may look red, purple or brown.

Lesions may be slightly raised and solid but smooth (called papules). They also may be flat, thickened areas of skin (called plaques). Larger bumps are often called nodules or tumors.

The condition may involve only one lesion or several. And lesions may appear on only one part of your body or multiple areas. They may be close together or spread out.

Rarely, some people also experience other symptoms, sometimes referred to as “B” symptoms, including:


Diagnosis of Cutaneous B-Cell Lymphoma

CBCL lesions can look like pimples, bug bites, allergic reactions, scabs or skin conditions (such as eczema or psoriasis). Because of this, many patients wait to seek medical attention. But if you have any skin abnormalities, you should talk to a healthcare provider, such as your primary care provider or a dermatologist.

Your healthcare provider can diagnose CBCL with a physical examination and skin biopsy. During a physical exam, your healthcare provider will look at your skin all over your body, carefully assessing any abnormalities. During a skin biopsy, they’ll remove a small piece of tissue so an expert can look at it under a microscope. A biopsy can identify skin lymphoma and its subtype.

Your healthcare provider might order staging tests to determine whether the cancer has spread. These tests might include:


Treatment of Cutaneous B-Cell Lymphoma

Treatment for CBCL depends on the subtype and stage. Treatment options include:

  • Active surveillance, or “watch and wait,” which involves monitoring the condition until treatment is necessary.

  • Chemotherapy

  • Medications rubbed on your skin (topical) or injected, such as corticosteroids

  • Radiation therapy

  • Monoclonal antibodies such as rituximab

  • Surgical removal.


Survival rate of cutaneous B-cell Lymphoma

Prognosis depends on several factors, especially subtype and stage.

The two slow-growing subtypes have a five-year survival rate of about 95%. That means 95% of people are alive five years after diagnosis. But the more aggressive subtypes have a five-year survival rate of 60%.

Bay Biosciences is a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens, and human bio-fluid collections.

Samples available include cancer (tumor) tissue, cancer serum, cancer plasma, cancer, peripheral blood mononuclear cells (PBMC). and human tissue samples from most other therapeutic areas and diseases.

Bay Biosciences maintains and manages its own biorepository, the human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and from normal healthy donors available in all formats and types.

Our biobank procures and stores fully consented, deidentified and institutional review boards (IRB) approved human tissue samples and matched controls.

All our human tissue collections, human specimens and human bio-fluids are provided with detailed, samples associated patient’s clinical data.

This critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers, and genetic information.

Patient’s data is extremely valuable for researchers and is used to help identify new effective treatments (drug discovery & development) in oncology, and other therapeutic areas and diseases.

Bay Biosciences banks wide variety of human tissue samples and biological samples, including cryogenically preserved at – 80°C.

Including fresh frozen tissue samples, tumor tissue samples, formalin-fixed paraffin-embedded (FFPE), tissue slides, with matching human bio-fluids, whole blood and blood-derived products such as serum, plasma and PBMC.

Bay Biosciences is a global leader in collecting and providing human tissue samples according to the specified requirements and customized, tailor-made collection protocols.

Please contact us anytime to discuss your special research projects and customized human tissue sample requirements.

Bay Biosciences provides human tissue samples (human specimens) from diseased and normal healthy donors which includes:

We can also procure most human bio-specimens, special collections and requests for human samples that are difficult to find. All our human tissue samples are procured through IRB-approved clinical protocols and procedures.

In addition to the standard processing protocols, Bay Biosciences can also provide human plasma, serum, and PBMC bio-fluid samples using custom processing protocols; you buy donor-specific collections in higher volumes and specified sample aliquots from us.

Bay Biosciences also provides human samples from normal healthy donors; volunteers, for controls and clinical research, contact us Now.

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