Bay Biosciences provides high quality, clinical grade, frozen sera (serum) with matched K2-EDTA plasma and peripheral blood mononuclear cells (PBMC) samples from unique epilepsy patients.

The sera (serum), K2-EDTA plasma and PBMCs are processed from epilepsy patient’s peripheral whole-blood using customized collection and processing protocols.

Epilepsy Overview

Epilepsy, which is also known as a seizure disorder, is a brain condition that causes recurring seizures. There are many types of epilepsy. In some people, the cause can be identified, but In other cases, the cause is unknown.

The Centers for Disease Control and Prevention (CDC) describe epilepsy as “a common brain condition that causes repeated seizures.”

In fact, patients with epilepsy usually experience recurrent seizures. However, these seizures occur due to a disruption of electrical activity in the brain, which temporarily disturbs the messaging systems between brain cells.

Also, it is estimated that 1.2% of people in the United States have active epilepsy, according to the Centers for Disease Control and Prevention. The disease affects people of all genders, races, ethnic backgrounds and ages.

Although, the symptoms of seizures can vary widely. Some people may lose awareness during a seizure while others don’t. Some people stare blankly for a few seconds during a seizure. Others may repeatedly twitch their arms or legs, movements known as convulsions.

However, having a single seizure doesn’t mean you have epilepsy. Epilepsy is diagnosed if you’ve had at least two unprovoked seizures at least 24 hours apart. Unprovoked seizures don’t have a clear cause.

Although, treatment with medicines or sometimes surgery can control seizures for most people with epilepsy. However, some patients require lifelong treatment. For others, seizures go away. Some children with epilepsy may outgrow the condition with age.

How Common is Epilepsy?

In 2015, the CDC stated that epilepsy affected around 1.2% of the United States population. That amounts to approximately 3.4 million people, including 3 million adults and 470,000 children.

The World Health Organization (WHO) estimate that epilepsy affects approximately 50 million people worldwide.


Symptoms of Epilepsy

The main symptom of epilepsy is recurrent seizures. However, if a person experiences one or more of the following symptoms, they should seek medical attention, as it may indicate epilepsy:

  • A convulsion with no fever
  • Short blackouts or confused memory
  • Intermittent fainting spells, during which they lose bowel or bladder control, frequently followed by extreme tiredness
  • Sudden falling for no apparent reason
  • Temporary unresponsiveness to instructions or questions
  • Sudden bouts of chewing without any clear reason
  • Temporarily seeming dazed and unable to communicate
  • Repetitive movements that seem involuntary
  • Fearfulness for no apparent reason
  • Panic or anger
  • Sudden stiffness for no apparent reason
  • Peculiar changes in senses, such as smell, touch, and sound
  • Sudden bouts of blinking without apparent stimuli
  • Jerking arms, legs, or body, which will appear as a cluster of rapid jerking movements in babies

It is vital to seek consultation with a doctor if any of these symptoms occur repeatedly.

Other Conditions Similar to Epilepsy

The following conditions may cause similar symptoms to those above, so some people can mistake them for those of epilepsy:

  • Cataplexy, or periods of extreme muscle weakness
  • Fainting
  • High fever with epilepsy-like symptoms
  • Nightmares
  • Panic attacks
  • Sleep disorders
  • Fugue state, a rare psychiatric condition in which a person forgets details about their identity
  • Nacrolepsy, or recurring episodes of sleep during the day
  • Psychogenic seizures, or seizures with a psychological or psychiatric cause


Treatment of Epilepsy

There is currently no cure for most types of epilepsy.

A doctor may prescribe antiepileptic drugs (AEDs) to help prevent seizures. If these drugs do not work, some other potential options include surgery, vagus nerve stimulation, or a special diet.

Doctors’ objective is to prevent further seizures. They also aim to prevent side effects so that the person can lead an active and productive life.


AEDs

AEDs appear to help control seizures in around 60–70% of cases, according to the American Epilepsy Society. The type of seizure a person has will decide which specific drug the doctor will prescribe.

People take the majority of AEDs by mouth. Common medications for treating epilepsy include:

  • Carbamazepine
  • Lamotrigine
  • Levetiracetam
  • Valproic acid

It is important to note that some drugs may prevent seizures in one person but not in another. Also, even when a person finds the right drug, it may take some time to find the ideal dosage.

Surgery

If at least two medications have been ineffective in controlling seizures, a doctor may consider recommending epilepsy surgery. A 2013 study from Sweden found that 62% of adults and 50% of children with epilepsy had no seizures for around 7 years after epilepsy surgery.

According to the National Institute of Neurological Disorders and Stroke, some surgical options include:

  • Lobectomy: During this procedure, a surgeon will remove the section of the brain in which seizures start. This is the oldest type of epilepsy surgery.
  • Multiple subpial transection: During this procedure, a surgeon will make several cuts to limit seizures to one part of the brain.
  • Corpus callosotomy: A surgeon will cut the neural connections between the two halves of the brain. This prevents seizures from spreading from one side of the brain to the other.
  • Hemispherectomy: In extreme cases, a surgeon may need to cut out a hemisphere, which is one half of the cerebral cortex of the brain.

For some patients, undergoing surgery may reduce the frequency and severity of their seizures. However, it is often important to continue taking antiseizure medication for several years following the procedure.

Another surgical option is the implantation of a device in the chest to stimulate the vagus nerve in the lower neck. The device sends preprogrammed electrical stimulation to the brain to help reduce seizures.

Diet

Diet may play a role in reducing seizures. A 2014 review of research that appeared in the journal Neurology suggested that high fat, low  carbohydrate diets could benefit children and adults with epilepsy.

Five of the studies in the review used the ketogenic diet, while another five used a modified Atkins diet. Typical foods in these diets include eggs, bacon, avocados, cheese, nuts, fish, and certain fruits and vegetables.

The review found that 32% of study participants adhering to the ketogenic diet and 29% of those following the modified Atkins diet experienced at least a 50% drop in the regularity of seizures. However, many participants had difficulty maintaining these diets.

Specific diets may be beneficial in some cases, but more research is needed to confirm this.


Causes of Epilepsy

Messaging systems in the brain control every function in the human body. Epilepsy develops due to a disruption in this system, which may result from brain dysfunction.

In many cases, healthcare professionals will not know the exact cause. Some people inherit genetic factors that make epilepsy more likely to occur. Other factors that may increase the risk include:

  • AIDS
  • Brain conditions, including stroke and tumors 
  • Cysticercosis
  • Developmental conditions, including autism and neurofibromatosis
  • Head trauma, such as from a vehicle accident
  • Infectious diseases, such as viral  encephalitis
  • Prenatal injury or brain damage that occurs before birth

According to the CDC, epilepsy is most likely to develop in children under 2 years and adults over 65 years.


Types of Epilepsy

Doctors can sometimes identify the cause of a person’s seizures. There are two main types of seizure based on whether or not they can determine the cause:

  • Idiopathic, or cryptogenic: There is no apparent cause, or the doctor cannot pinpoint one.
  • Symptomatic: The doctor knows what the cause is.

Also, there are three seizure descriptors — partial, generalized, and secondary generalized — depending on which area of the brain the seizure originates in.

However, a person’s experience during a seizure will depend on the affected brain area and how widely and quickly the electrical activity in the brain spreads from that initial area.

Partial Seizure

A partial seizure occurs when the epileptic activity takes place in one part of a person’s brain.

There are two subtypes of partial seizure:

  • Simple partial seizure: During this type of seizure, the person is conscious. In most cases, they are also aware of their surroundings, even when the seizure is in progress.
  • Complex partial seizure: During this type, the seizure impairs a person’s consciousness. They will generally not remember the seizure. If they do, their memory of it will be vague.

Generalized Seizure

A generalized seizure occurs when the epileptic activity affects both halves of the brain. The person will usually lose consciousness while the seizure is in progress.

In fact, there are several subtypes of generalized seizure, including:

Tonic-clonic seizures: Perhaps the best-known type of generalized seizure, tonic-clonic seizures cause loss of consciousness, body stiffness, and shaking. Doctors previously called these grand mal seizures.

  • Absence seizures: Previously known as petit mal seizures, these involve short lapses of consciousness wherein the individual appears to be staring off into space. Absence seizures often respond well to treatment.
  • Tonic seizures: In tonic seizures, the muscles become stiff, and the person may fall.
  • Atonic seizures: A loss of muscle tone causes the individual to drop suddenly.
  • Clonic seizures: This subtype causes rhythmic, jerking movements, often in the face or one arm or leg.
  • Myoclonic seizures: This subtype causes the upper body or legs to suddenly jerk or twitch.

Secondary Generalized Seizure

A secondary generalized seizure occurs when the epileptic activity starts as a partial seizure but spreads to both halves of the brain. As this seizure progresses, the person will lose consciousness.


Diagnosis of Epilepsy

A doctor will review an individual’s medical history and the symptoms they have experienced, including a description and timeline of past seizures, to diagnose epilepsy.

They may also request tests to determine the type of epilepsy and the type of seizures the person has. Based on these results, the doctor will be able to recommend treatment options, such as anti-seizure medications.

Diagnostic Tests for Epilepsy

Several types of imaging test can help a doctor diagnose epilepsy. These tests include:

  • An EEG, to look for abnormal brain waves
  • CT and MRI scans to detect tumors or other structural irregularities
  • Functional MRI scans, which can identify normal and abnormal brain function in specific areas
  • Single-photon emission CT scans, which may be able to find the original site of a seizure in the brain
  • A magnetoencephalogram, which can identify irregularities in brain function using magnetic signals

The doctor may also use blood tests to identify any underlying conditions that could be causing the epilepsy. Neurological tests may also help a doctor determine the type of epilepsy the person has.


Is Epilepsy Genetic?

According to one 2015 research review, around 70–80% of epilepsy cases occur as a result of genetics.

A 2017 review of research linked over 900 genes to epilepsy. This number continues to grow as more studies take place.

Genes may link to epilepsy directly, to brain anomalies that can lead to epilepsy, or to other genetic conditions that can cause seizures.

Some people inherit genetic factors. However, certain genetic mutations may also cause epilepsy in people without a family history of the condition.

A doctor may sometimes request genetic testing to determine the cause of epilepsy.


Triggers of Epilepsy

A variety of factors can lead to seizures. One 2014 study identified stress, sleep deprivation, and fatigue as the most frequent triggers among 104 participants. Although, flickering lights and high levels of alcohol consumption can also cause seizures.

Also, stress is a common cause of seizures, but the reason is unclear. Research from 2016 in the journal Science Signaling focused on this trigger. The team found that the brain’s stress response worked differently in rats with epilepsy than in those without.

However, the study also found that the molecule that typically suppresses brain activity in response to stress enhanced activity instead. This may contribute to seizures.

Epilepsy vs. Seizures

Seizures are the main symptom of epilepsy. In fact, Johns Hopkins Medicine define epilepsy as having “two or more unprovoked seizures.”

Although, some people may have a single seizure, or they may experience seizures that are not due to epilepsy.

However, it is even possible for doctors to misdiagnose nonepileptic seizures as epilepsy. However, nonepileptic seizures do not stem from abnormal electrical activity in the brain. The causes of these can be physical, emotional, or psychological.

Also, there are also different types of seizure, which may vary among people with epilepsy. In two people with epilepsy, for example, the condition may look different.

Accordingly, for this reason, the CDC describe epilepsy as a spectrum disorder.


Is Epilepsy a Disability?

The Americans with Disabilities Act (ADA) prohibits discrimination against people with disabilities, including epilepsy. This applies whether or not the person is able to manage their seizures with medication or surgery.

Patients with epilepsy have certain employment-related protections under the ADA, including the following:

  • Employers may not ask about job applicants’ medical conditions, including epilepsy.
  • Job applicants do not need to inform an employer that they have epilepsy unless they need reasonable accommodation during the application period.
  • Employers may not cancel a job offer if the person can complete the primary functions of the job.

According to the Social Security Administration, people with epilepsy may be eligible for disability benefits. Also, this requires that people document their seizure type and frequency while taking all the prescribed medications.


Warning Devices for Epilepsy

Some devices can monitor seizures and alert caregivers, potentially benefiting treatment and helping prevent sudden unexpected death in epilepsy (SUDEP).

A 2018 study involving 28 participants, the results of which appeared in the journal Neurology, compared one such multimodality device, the Nightwatch, to an Emfit bed sensor. The Nightwatch detected 85% of all severe seizures, compared with 21% for the bed sensor. It also only missed one serious attack every 25 nights.

Nearly 70% of SUDEP cases occur during sleep, according to one 2017 study. This indicates that there may be potential benefits of using accurate nighttime warning systems.


Is Epilepsy Contagious?

Anyone can develop epilepsy, but it is not contagious. A 2016 review of research highlighted some misconceptions and stigma about epilepsy, including the false belief that epilepsy can transmit between people.

Although, the study authors note that people with lower education levels and socioeconomic status had a high rate of misconceptions, as did those who did not know any people with epilepsy.

As a result, interventions and other educational efforts may be useful to reduce stigma around epilepsy and increase understanding of the condition.


Prognosis

Epilepsy can impair a person’s life in multiple ways, and the outlook will depend on various factors.

Although, seizures can sometimes be fatal, depending on the circumstances. However, many people with epilepsy can manage their seizures using antiseizure medications.

While, more research is necessary to confirm the alleged relationship between seizures and brain damage.


Is Epilepsy Fatal?

Seizures can lead to drowning, falling, vehicle accidents, or other injuries that could be fatal. Although it is rare, SUDEP can also occur.

Cases of SUDEP typically occur during a seizure or immediately after it. For example, the seizure may cause the person to go too long without breathing, or it could result in heart failure.

The exact cause of SUDEP is unclear, but a 2018 animal study suggested that acid reflux  could explain it.

After blocking acid from reaching the esophagus, SUDEP did not occur in the rats the researchers tested. It is not clear whether this has any relevance to humans, however.

According to the CDC, people are at more risk of SUDEP if they have had epilepsy for many years, or if they have regular seizures. Following these steps can help reduce the risk of SUDEP:

  • Getting sufficient sleep 
  • Limiting alcohol intake
  • Taking all doses of antiseizure medication

Although, regularly taking prescribed medication may also help prevent status epilepticus, a condition wherein seizures last for longer than 5 minutes.

A 2016 study found that treating status epilepticus within 30 minutes reduced the risk of death.


Remission of Seizures

A 2013 review of research in the journal Brain indicated that 65–85% of people may experience long-term remission of seizures.

Seizures with an identifiable cause, however, are more likely to continue.

Other factors affecting the chances of remission include:

  • Access to treatment
  • Response to treatment
  • Other health conditions a person may have

With the correct use of anti-seizure medications, the majority of people with epilepsy may be able to control their seizures.


Epilepsy Leading to Brain Damage

Research into whether or not seizures can cause brain damage has shown mixed outcomes.

A 2018 study examined postsurgical brain tissue from people with recurrent seizures. The researchers found no brain damage markers in patients with certain types of epilepsy.

However, several other studies have suggested that severe, long lasting seizures could lead to brain injury. For example, one 2013 study found that seizures could result in brain abnormalities, with status epilepticus causing irreversible brain lesions.

Although, other studies have looked at cognitive changes in children as they get older, either with or without epilepsy. Results suggest that epilepsy is associated with worse cognitive outcomes.

However, it is unclear whether:

  • epilepsy causes the impairment
  • a similar structural change causes both epilepsy and the impairment
  • antiepileptic drugs have an effect

Further research is required in this area.

Other Effects

Epilepsy can affect various aspects of a person’s life, including their:

  • Ability to study and work
  • Emotions and behavior
  • Social development and interaction

The scale of impact on these areas of life will depend largely on the frequency and severity of their seizures.


Life Expectancy of Epilepsy Patients

In 2013, researchers from the University of Oxford and University College London, both in the United Kingdom, reported that people with epilepsy are 11 times more likely to experience premature death than people without it..

In fact, the risk appears to be greater if the person also has a mental health condition. Suicide, accidents, and assaults accounted for 15.8% of early deaths. However, most patients affected by these had also received a diagnosis of a mental health condition.

Lead researcher Seena Fazel says, “Our results have significant public health implications, as around 70 million people worldwide have epilepsy, and they emphasize that carefully assessing and treating psychiatric disorders as part of standard checks in [patients] with epilepsy could help reduce the risk of premature death in these patients.”

“Our study,” he adds, “also highlights the importance of suicide and nonvehicle accidents as major preventable causes of death in people with epilepsy.”


Risk Factors of Epilepsy

Several factors may have links to an increased risk of epilepsy. According to a 2017 research in the journal NeuroToxicology, these factors include:

  • Age, with new cases occurring more frequently in young children and older adults
  • Alcohol consumption
  • Brain injuries and tumors
  • Genetics and family history
  • Perinatal factors, such as stroke and preterm birth
  • Central nervous system (CNS) infections, such as bacterial meningitis, viral encephalitis, and neurocysticercosis

Some risk factors, such as alcohol consumption, are modifiable when trying to prevent the development of epilepsy.


Is Epilepsy Curable?

There is currently no cure for epilepsy, but people with the condition can usually manage their symptoms.

According to the WHO, up to 70% of people with epilepsy can experience a reduction in their seizure frequency and severity with anti-seizure medications. Around half of all people with epilepsy may be able to stop taking medications after 2 years without a seizure.

Also, in some cases, surgery can also reduce or eliminate seizures when drugs are ineffective.

Although, this can have long-term benefits. In one 2018 study, 47% of the participants reported no debilitating seizures 5 years after surgery, and 38% reported the same after 10 years.


Complications of Epilepsy

Depending on the situation, seizures may lead to negative outcomes such as drowning or vehicle accidents. Long lasting seizures, or status epilepticus, may also cause brain damage or death.

In fact, patients with epilepsy are eight times more likely than people without it to experience certain other chronic conditions, including dementia, migraine, heart disease, and depression. However, some of these conditions could also make seizures worse.

Although. other complications may occur due to the side effects of antiseizure medications. For example, one 2015 study found that 9.98% of people taking the antiseizure drug lamotrigine (Lamictal) developed a skin rash.

Also, rash can also occur with other AEDs, including phenytoin (Dilantin) and phenobarbital. The rash usually disappears once the person stops taking the medication. However, 0.8%–1.3% of adults developed a serious rash that could be fatal.


Prevention of Epilepsy

The WHO explain that around 25% of epilepsy cases are preventable. People can reduce the risk of developing epilepsy by following these steps:

  • Managing risk factors for stroke and heart disease, which could cause brain damage that results in epilepsy
  • practicing good hygiene and preventative methods to avoid cysticercosis, an infection that is the most common cause of epilepsy around the world, according to the CDC.
  • Seeking perinatal care, to prevent epilepsy from birth injuries
  • Wearing a helmet when riding a bicycle or motorcycle, to help prevent head injuries

A 2015 review of research in the journal Seizure also suggested that regular physical activity may help prevent the development of epilepsy and reduce how often seizures occur.

Although, it is not possible to prevent all cases of epilepsy. However, taking the above steps may help reduce the risk.


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Samples available include cancer (tumor) tissue, cancer serum, cancer plasma, cancer, peripheral blood mononuclear cells (PBMC). and human tissue samples from most other therapeutic areas and diseases.

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In fact, our biobank procures and stores fully consented, de-identified and institutional review boards (IRB) approved human tissue samples and matched controls.

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So this critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers, and genetic information.

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Bay Biosciences also provides human samples from normal healthy donors; volunteers, for controls and clinical research, contact us Now.

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