Atopic Dermatitis Samples for Research

Bay Biosciences provides fresh frozen (-80°) high quality, clinical grade sera (serum) and plasma biofluid samples from atopic dermatitis patients for research.

The atopic dermatitis samples for research are processed from patient’s whole-blood using customized collection and processing protocols.

Atopic Dermatitis Overview

Atopic dermatitis also known as eczema is a chronic skin condition involving patches of dry, inflamed, and itchy skin. Furthermore, it can affect both children and adults. Fortunately, various treatments can help manage symptoms.

To clarify, “eczema” refers to a broader group of skin conditions. In addition, dermatitis relates to skin conditions, and atopic diseases are diseases caused by allergic reactions.

Typically, atopic dermatitis often starts in childhood and tends to flare up periodically. During flare-ups, people with atopic dermatitis often scratch the affected area. Consequently, this scratching can lead to more skin inflammation and worsen symptoms.

Currently, there’s no cure for atopic dermatitis; however, you can manage symptoms effectively. Specifically, treatment involves avoiding triggers, making lifestyle changes, and taking medications to ease symptoms.

Therefore, keep reading to learn more about atopic dermatitis, including what it looks like, its causes, treatments, and potential complications.

Symptoms of Atopic Dermatitis

The primary symptom of atopic dermatitis is itchy skin.

Additionally, other symptoms can include the following:

  • Dryness
  • Hardening or thickening of the skin
  • Redness or discoloration

Furthermore, eczema flares are part of the itch-scratch cycle. This means that the more you scratch, the more the skin itches, and that can lead to more scratching.

Moreover, atopic dermatitis can have different symptoms depending on a person’s age.

Symptoms in Infants

Atopic dermatitis symptoms in infants can include:

– A a rash on the scalp or cheeks
– Dry, itchy, scaly skin
– Oozing and crusting

Additionally, infants with these symptoms may have trouble sleeping due to itchy skin.

Furthermore, infants with atopic dermatitis may also develop skin infections from scratching.

Symptoms in Children

Atopic dermatitis symptoms in children from the age of around 2 years can include:

  • A rash in the creases of the elbows, knees, or both
  • Extremely dry and scaly skin
  • Lightened or darkened skin spots
  • Rashes on the neck and face, especially around the eyes
  • Scaly patches of skin at the site of the rash
  • Thick, leathery skin

Symptoms in Adults

In adults, atopic dermatitis is more likely to affect the hands. Moreover, adults are also more likely to have symptoms around their eyes.

Furthermore, adults who had atopic dermatitis as children or who have had the condition for a long time may, consequently, have discolored or leathery patches of skin that are easily irritated.

Causes of Atopic Dermatitis

The exact cause of atopic dermatitis is unclear. Furthermore, atopic dermatitis is not contagious, so you can’t give the rash to someone else.

In addition, the basic understanding of atopic dermatitis is that inflammation results from a misdirected immune reaction. Consequently, this immune reaction causes too many inflammatory cells in your skin. Moreover these cells cause many of the condition’s symptoms.

As a result, people with atopic dermatitis tend to have dry skin because of an altered skin barrier. Furthermore, with atopic dermatitis, the skin is more prone to water loss and the entry of irritants.

Triggers of Atopic Dermatitis

Atopic dermatitis flare-ups can have various triggers. For instance, examples of lifestyle and environmental triggers of atopic dermatitis flares include:

  • Cigarette smoke
  • Dander
  • Frequent or lengthy exposure to hot water, such as hot showers or baths
  • Heat
  • Pollen
  • Scratching
  • Sweat
  • Soaps, detergents, and cleaners
  • Stress
  • wool

Furthermore, avoiding known triggers may help manage the frequency of flares or severity of symptoms. Therefore, you can work with your doctor to identify what triggers may cause an atopic dermatitis flare.

Diagnosis of Atopic Dermatitis

Doctors can diagnose atopic dermatitis by asking questions about symptoms, taking your medical history, and performing a physical exam.

Furthermore, in some cases, they may order tests to confirm the diagnosis and rule out other types of eczema. For instance, tests that can help includeTrusted Source:

Treatment of Atopic Dermatitis

While there’s no cure for atopic dermatitis, treatments can help manage symptoms.

In fact, doctors may recommend a combination of home remedies and medical treatments.

Home Remedies

Specifically home remedies for atopic dermatitis can include:

  • Avoiding fragranced soaps and washes
  • Applying moisturizer, particularly after bathing
  • Taking oatmeal baths
  • Keeping fingernails short or wearing gloves to avoid scratching
  • Taking baking soda baths

Over-the-counter (OTC) treatments

OTC treatments for atopic dermatitis can include:

  • Antihistamines
  • Pain relievers such as ibuprofen and acetaminophen
  • Topical corticosteroids, such as hydrocortisone

Medical Treatment

A doctor may prescribe more powerful corticosteroids than those available OTC to help you manage inflammation and itchiness.

Moreover, the injectable biologic medication dupilumab may help treat atopic dermatitis that does not respond to other treatments. Specifically, it works by reducing the release of signaling molecules called interleukins that promote inflammation. Consequently, doctors may recommend it for adults and children ages 6 months and up.

In addition, your doctor may also prescribe medicated bandages or wet wraps to apply over affected areas to keep your skin moist and prevent itchiness.

Detailed clinical data and pathology annotations including patient’s corresponding diagnostic test values associated with the biospecimens are provided to a valued pharmaceutical customer for diagnostics, research, development and drug discovery.

Furthermore, Bay Biosciences is a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples. We provide biospecimens and human bio-fluid collections from cancer (tumor) tissue, cancer serum, cancer plasma cancer PBMC and human tissue samples from most other therapeutic areas and diseases.

In addition, Bay Biosciences maintains and manages it’s own bio-repository, human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and from normal healthy donors available in all formats and types. Our biobank procures and stores fully consented, deidentified and institutional review boards (IRB) approved human tissue samples and matched controls.

All our human human tissue collections, human specimens and human bio-fluids are provided with detailed samples associated patient’s clinical data.

Moreover, this critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers and genetic information.

Furthermore, patient’s data is extremely valuable for researchers and is used to help identify new effective treatments (drug discovery & development) in oncology, other therapeutic areas and diseases. This clinical information is critical to demonstrate their impact, monitor the safety of medicines, testing & diagnostics, and generate new knowledge about the causes of disease and illness. 

We bank wide variety of human tissue samples and biological samples including cryogenically preserved -80°C, fresh, fresh frozen tissue samples, tumor tissue samples, FFPE’s, tissue slides, with matching human bio-fluids, whole blood and blood derived products such as serum, plasma and PBMC’s.

Bay Biosciences specializes in collecting and providing human tissue samples according to the researchers specified requirements and customized, tailor made collection protocols. Please contact us anytime to discuss your special research projects and customized human tissue sample requirements.

Bay Biosciences provides human tissue samples (human specimens) from diseased and normal healthy donors; including the following

  • Aqueous humor
  • Amniotic fluid
  • Bronchoalveolar lavage fluid (BAL)
  • Buffy coat
  • Cerebrospinal fluid (CSF)
  • Kidney stones
  • Sputum
  • Nephrolithiasis
  • Pleural effusion 
  • Peripheral whole-blood
  • Plasma
  • Renal calculi
  • Serum (sera)
  • Peripheral blood mononuclear cells (PBMC’s)
  •  Saliva
  •  Stool samples,
  • Vitreous humor
  • Urolithiasis and other bodily fluids from most diseases including cancer.

Moreover, we can also procure most human bio-specimens and can do special collections and requests of human samples that are difficult to find. All our human tissue samples are procured through IRB approved clinical protocols and procedures. 

In addition to the standard processing protocols Bay Biosciences can also provide human plasma, serum, PBMC bio-fluid samples using custom processing protocols, you can buy donor specific sample collections in higher volumes and specified sample aliquoting from us. Bay Biosciences also provides human samples from normal healthy donors, volunteers, for controls and clinical research, contact us Now.

 

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