Bay Biosciences provides high quality, clinical grade bio-samples, liver biopsy tissue, sera (serum), plasma, peripheral blood mononuclear cells (PBMC) bio-fluid specimens from patients diagnosed with Type-1 autoimmune hepatitis disease.

Moreover, the serum, plasma and PBMCs are processed from patient’s peripheral whole-blood using customized processing protocols.

Furthermore, the samples are collected from patients diagnosed with from autoimmune hepatitis and provided to a valued pharmaceutical customer for research.

In addition, detailed clinical annotations, associated with the samples are provided to a valued customer for drug discovery, development and research.

Finally, the autoimmune hepatitis disease samples are processed from patients peripheral blood using customized processing protocols provided by the researcher.

Autoimmune Hepatitis Overview

Autoimmune hepatitis is a liver inflammation disease in which the body’s immune system attacks liver cells. Consequently, this immune response causes inflammation of the liver, also called hepatitis.

Furthermore, the disease can be very serious and, if not treated, it gets worse over time, ultimately leading to cirrhosis of the liver, which can result in liver failure. In addition, autoimmune hepatitis likely results from a combination of autoimmunity, environmental triggers, and a genetic predisposition.

Symptoms

Signs and symptoms of autoimmune hepatitis vary from person to person and may come on suddenly. Some patients have few, if any, recognized problems in the early stages of the disease, whereas others experience signs and symptoms that may include:

  • Abdominal pain, discomfort
  • Abnormal blood vessels on the skin (spider angiomas)
  • Enlarged liver
  • Fatigue
  • Skin rashes
  • Joint pains
  • Loss of menstrual periods
  • Yellowing of the skin and whites of the eyes (jaundice)

Types of Autoimmune Hepatitis

There are two main forms of autoimmune hepatitis:

  • Type-1 Autoimmune Hepatitis- This is the most common type of autoimmune
    hepatitis. It can occur at any age. About half the people with type-1 autoimmune hepatitis have other autoimmune disorders, such as celiac disease, rheumatoid arthritis or ulcerative colitis.
  • Type 2 autoimmune hepatitis- Although adults can develop type 2 autoimmune hepatitis, it’s most common in children and young people. Other autoimmune diseases may accompany this type of autoimmune hepatitis.

Causes of Autoimmune Hepatitis

Autoimmune hepatitis occurs when the body’s immune system, which usually attacks viruses, bacteria, and other causes of disease, instead targets the liver. Consequently, this attack on the liver can lead to long-lasting inflammation and serious damage to liver cells. Just why the body turns against itself is unclear.

However, researchers think that the interaction of genes controlling immune system function and exposure to viruses or medicines could cause autoimmune hepatitis.

Risk Factors

Furthermore, factors that may increase your risk of autoimmune hepatitis include:

  • First, being female: Although both males and females can develop autoimmune hepatitis, the disease is most common in females.
  • Next, Genetics: In addition, evidence suggests that families may carry a predisposition to autoimmune hepatitis.
  • In addition, having an autoimmune disease: Moreover, people who already have an autoimmune disease, such as celiac disease, rheumatoid arthritis (RA), or hyperthyroidism (Grave’s disease
    or Hashimoto thyroiditis), may be more likely to develop autoimmune hepatitis.

Complications

Autoimmune hepatitis that goes untreated can cause permanent scarring of the liver tissue (cirrhosis) and other following complications of liver cirrhosis include:

  • First, Enlarged Veins in the esophagus (esophageal varices): When circulation through the portal vein is blocked, blood may back up into other blood vessels, mainly those in the stomach and esophagus. The blood vessels are thin walled, and because they’re filled with more blood than they’re meant to carry, they’re likely to bleed. Massive bleeding in the esophagus or stomach from these blood vessels is a life-threatening emergency that requires immediate medical care.
  • Next, Fluid in the Abdomen (ascites): Liver disease can cause large amounts of fluid to accumulate in the abdomen. Ascites can be uncomfortable and may interfere with breathing and is usually a sign of advanced cirrhosis.
  • Additionally, Liver Failure: This occurs when extensive damage to liver cells makes it impossible for the liver to function adequately. At this point, a liver transplant is needed.
  • Finally, Liver Cancer: Patients with cirrhosis have an increased risk of liver cancer.

Biospecimens

biospecimens

Bay Biosciences is a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens, and human bio-fluid collections.

Moreover, human biospecimens are available including tumor tissue, serum, plasma and PBMC samples from most other therapeutic areas.

Furthermore, Bay Biosciences maintains and manages its own biorepository, the human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and likewise normal healthy donors for controls. Additionally, available in all formats and types.

In fact, our biobank procures and stores fully consented, de-identified and institutional review boards (IRB) approved human tissue samples, human biofluids such as serum samples, plasma samples from various diseases and matched controls.

Also, all our human tissue collections, human biospecimens and human biofluids are provided with detailed, samples associated patient’s clinical data.

In fact, this critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers, and genetic information.

Additionally, researchers find the patient’s data associated with the human biospecimens extremely valuable and use it to help identify new effective treatments (drug discovery & development) in oncology, as well as in other therapeutic areas and diseases.

Bay Biosciences banks wide variety of human tissue samples and human biological samples, including fresh frozen human biospecimens cryogenically preserved at – 80°C.

For example fresh frozen tissue samples, tumor tissue samples, formalin-fixed paraffin-embedded (FFPE), tissue slides, with matching human bio-fluids, whole blood and blood-derived products such as human serum, human plasma and human PBMCs.

Bay Biosciences is a global leader in collecting and providing human tissue samples according to the specified requirements and customized, tailor-made collection protocols.

Please contact us anytime to discuss your special research projects and customized human tissue sample requirements.

Types of Biospecimens

Bay Biosciences provides human tissue samples (human specimens) and human biofluids from diseased and normal healthy donors which includes:

Moreover, we can also procure most human biospecimens and human biofluids, special collections and requests for human samples that are difficult to find. All our human tissue samples and human biofluids are procured through IRB-approved clinical protocols and procedures.

In addition to the standard processing protocols, Bay Biosciences can also provide human biofluids such as  human plasma, human serum, and human PBMCs bio-fluid samples using custom processing protocols; you buy donor-specific collections in higher volumes and specified sample aliquots from us.

Bay Biosciences also provides human biospecimens from normal healthy donors; volunteers, for controls and clinical research, Contact us Now.