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Back Pain Overview

Back pain is one of the most common problem which affect people at some point during our lives and it is a leading cause of disability worldwide.

Back pain often develops without a cause, doctors can identify the reason with a test or an imaging study. Back pain can range from a muscle aching to a shooting, burning or stabbing sensation. In addition, the pain may radiate down your leg or worsen with bending, twisting, lifting, standing or walking.

Most acute low back pain results from injury to the muscles, ligaments, joints, or discs. The body also reacts to injury by mobilizing an inflammatory healing response. While inflammation sounds minor, it can cause severe pain.

There is a significant overlap of nerve supply to many of the discs, muscles, ligaments, and other spinal structures, and it can be difficult for the brain to accurately sense which is the cause of the pain.

Causes of Back Pain

The single most common cause of lower back pain is a torn or pulled muscle and/or ligament. Following are some of the common conditions linked to back pain:

Muscle Strain and Ligament Sprain

A lower back sprain or strain can happen suddenly, or can develop slowly over time from repetitive movements. Strains occur when a muscle is stretched too far and tears, damaging the muscle itself.
Sprains happen when over-stretching and tearing affects ligaments, which connect the bones together.

Common causes of sprain and strain include:

  • Lifting a heavy object, or twisting the spine while lifting
  • Sudden movements that place too much stress on the low back, such as a fall
  • Poor posture over time
  • Sports injuries, especially in sports that involve twisting or large forces of impact

Other causes of Chronic Lower Back Pain

Pain is considered chronic once it lasts for more than three months and exceeds the body’s natural healing process. Chronic pain in the low back often involves a disc problem, a joint problem, and an irritated nerve root.

Following are the common causes of lower back pain:

  • Compression fracture
  • Deformity
  • Degenerative disc disease
  • Facet joint dysfunction
  • Lumbar herniated disc
  • Osteoarthritis
  • Sacroiliac joint dysfunction
  • Spinal stenosis
  • Spondylolisthesis
  • Trauma

Signs and Symptoms of Back Pain

Back pain can have many symptoms, following are some of the common signs and symptoms of back pain:

  • Decrease range of movement and motion
  • Reduced ability to flex the back without pain
  • Stabbing or shooting pain that may radiate down the leg and to the food
  • Pain and aching sensation in the lower back
  • Being not able to stand up straight

Bay Biosciences is a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens and human bio-fluid collections. 

Samples available are cancer (tumor) tissue, cancer serum, cancer plasma cancer PBMC and human tissue samples from most other therapeutic areas and diseases.

Bay Biosciences maintains and manages its own bio-repository, human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and from normal healthy donors available in all formats and types.

Our biobank procures and stores fully consented, deidentified and institutional review boards (IRB) approved human tissue samples and matched controls.

All our human tissue collections, human specimens and human bio-fluids are provided with detailed samples associated patient’s clinical data.

This critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers and genetic information.

Patient’s data is extremely valuable for researchers and is used to help identify new effective treatments (drug discovery & development) in oncology, other therapeutic areas and diseases. 

This clinical information is critical to demonstrate their impact, monitor the safety of medicines, testing & diagnostics, and generate new knowledge about the causes of disease and illness. 

Bay Biosciences banks wide variety of human tissue samples and biological samples including cryogenically preserved at – 80°C.

Including fresh frozen tissue samplestumor tissue samples, FFPE’s, tissue slides, with matching human bio-fluids, whole blood and blood derived products such as serumplasma and PBMC’s.

Bay Biosciences is a global leader in collecting and providing human tissue samples according to the researchers specified requirements and customized, tailor-made collection protocols.

Please contact us anytime to discuss your special research projects and customized human tissue sample requirements.

Bay Biosciences provides human tissue samples (human specimens) from diseased and normal healthy donors which includes:

  • Peripheral whole-blood,
  • Amniotic fluid
  • Bronchoalveolar lavage fluid (BAL)
  • Sputum
  • Pleural effusion
  • Cerebrospinal fluid (CSF)
  • Serum (sera)
  • Plasma
  • Peripheral blood mononuclear cells (PBMC’s)
  • Saliva
  • Buffy coat
  • Urine
  • Stool samples
  • Aqueous humor
  • Vitreous humor
  • Kidney stones (renal calculi)
  • Other bodily fluids from most diseases including cancer.

We can also procure most human bio-specimens and can-do special collections and requests of human samples that are difficult to find. All our human tissue samples are procured through IRB approved clinical protocols and procedures. 

In addition to the standard processing protocols Bay Biosciences can also provide human plasmaserum, PBMC bio-fluid samples using custom processing protocols, you can buy donor specific sample collections in higher volumes and specified sample aliquoting from us.

 Bay Biosciences also provides human samples from normal healthy donors, volunteers, for controls and clinical research, contact us Now.

 

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