Back Pain Overview

In fact, back pain is one of the most common problem which affect people at some point during our lives and it is a leading cause of disability worldwide.

Moreover, back pain often develops without a cause, doctors can identify the reason with a test or an imaging study. Furthermore, back pain can range from a muscle aching to a shooting, burning or stabbing sensation. In addition, the pain may radiate down your leg or worsen with bending, twisting, lifting, standing or walking.

Therefore, most acute low back pain results from injury to the muscles, ligaments, joints, or discs. Consequently, the body also reacts to injury by mobilizing an inflammatory healing response. However, while inflammation sounds minor, it can cause severe pain.

Additionally, there is a significant overlap of nerve supply to many of the discs, muscles, ligaments, and other spinal structures, and it can be difficult for the brain to accurately sense which is the cause of the pain.

Causes of Back Pain

The single most common cause of lower back pain is a torn or pulled muscle and/or ligament. Following are some of the common conditions linked to back pain:

Muscle Strain and Ligament Sprain

A lower back sprain or strain can happen suddenly, or can develop slowly over time from repetitive movements. Strains occur when a muscle is stretched too far and tears, damaging the muscle itself.
Sprains happen when over-stretching and tearing affects ligaments, which connect the bones together.

Common causes of sprain and strain include:

  • Lifting a heavy object, or twisting the spine while lifting
  • Sudden movements that place too much stress on the low back, such as a fall
  • Poor posture over time
  • Sports injuries, especially in sports that involve twisting or large forces of impact

Other causes of Chronic Lower Back Pain

Pain is considered chronic once it lasts for more than three months and exceeds the body’s natural healing process. Chronic pain in the low back often involves a disc problem, a joint problem, and an irritated nerve root.

Following are the common causes of lower back pain:

  • Compression fracture
  • Deformity
  • Degenerative disc disease
  • Facet joint dysfunction
  • Lumbar herniated disc
  • Osteoarthritis
  • Sacroiliac joint dysfunction
  • Spinal stenosis
  • Spondylolisthesis
  • Trauma

Signs and Symptoms of Back Pain

Back pain can have many symptoms, following are some of the common signs and symptoms of back pain:

  • Decrease range of movement and motion
  • Reduced ability to flex the back without pain
  • Stabbing or shooting pain that may radiate down the leg and to the food
  • Pain and aching sensation in the lower back
  • Being not able to stand up straight

Biospecimens

biospecimens

Bay Biosciences is a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens, and human bio-fluid collections.

Moreover, human biospecimens are available including tumor tissue, serum, plasma and PBMC Samples from most other therapeutic areas.

Furthermore, Bay Biosciences maintains and manages its own biorepository, the human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and likewise normal healthy donors for controls. Additionally, available in all formats and types.

In fact, our biobank procures and stores fully consented, de-identified and institutional review boards (IRB) approved human tissue samples, human biofluids such as serum samples, plasma samples from various diseases and matched controls.

Also, all our human tissue collections, human biospecimens and human biofluids are provided with detailed, samples associated patient’s clinical data.

In fact, this critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers, and genetic information.

Additionally, researchers find the patient’s data associated with the human biospecimens extremely valuable and use it to help identify new effective treatments (drug discovery & development) in oncology, as well as in other therapeutic areas and diseases.

Bay Biosciences banks wide variety of human tissue samples and human biological samples, including fresh frozen human biospecimens cryogenically preserved at – 80°C.

For example fresh frozen tissue samples, tumor tissue samples, formalin-fixed paraffin-embedded (FFPE), tissue slides, with matching human bio-fluids, whole blood and blood-derived products such as human serum, human plasma and human PBMCs.

Bay Biosciences is a global leader in collecting and providing human tissue samples according to the specified requirements and customized, tailor-made collection protocols.

Please contact us anytime to discuss your special research projects and customized human tissue sample requirements.

Types of Biospecimens

Bay Biosciences provides human tissue samples (human specimens) and human biofluids from diseased and normal healthy donors which includes:

Moreover, we can also procure most human biospecimens and human biofluids, special collections and requests for human samples that are difficult to find. All our human tissue samples and human biofluids are procured through IRB-approved clinical protocols and procedures.

In addition to the standard processing protocols, Bay Biosciences can also provide human biofluids such as  human plasma, human serum, and human PBMCs bio-fluid samples using custom processing protocols. you buy donor-specific collections in higher volumes and specified sample aliquots from us in multiple format and sets.

Bay Biosciences also provides human biospecimens from normal healthy donors; volunteers, for controls and clinical research, Contact us Now.