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COPD Bronchoalveolar Lavage (BAL) Samples

by | Apr 24, 2019 | Updates | 0 comments

Bay Biosciences provides fresh frozen bronchoalveolar lavage (BAL) samples from unique patients diagnosed with chronic obstructive pulmonary disease (COPD).

Detailed clinical data, serology, pathology, biomarkers annotations and drug information associated with the Chronic Obstructive Pulmonary Disease Patients (COPD) is provided to a valued pharmaceutical customer for development, discovery and research.

Chronic respiratory diseases (CRDs) are diseases of the airways and other structures of the lung. Some of the most common are chronic obstructive pulmonary disease (COPD), asthma, occupational lung diseases and pulmonary hypertension. According to the World Health Organization (WHO) more than 3 million people die each year from COPD an estimated 6% deaths worldwide. WHO predicts that COPD will become the third leading cause of death worldwide by 2030. In the United States COPD effects estimated 30 million people. Chronic lower respiratory disease, primarily COPD, was the third leading cause of death in the United States. The 20-year discounted direct medical costs attributable to COPD were estimated to be $800.90 billion, with an expected $337.13 billion in male subjects and $463.77 billion in female subjects.

Smoking both current smoking and smoking in the past, is the main cause of COPD in men and women in the U.S. Almost 15.7 million Americans (6.4%) reported that they have been diagnosed with COPD.  Although millions more may have COPD and not know it. About 85 to 90 percent of all COPD  cases are caused by cigarette smoking. When a cigarette burns, it creates more than 7,000 chemicals, many of which are harmful. The toxins in cigarette smoke weaken the lungs defense against infections, narrow air passages, cause swelling in air tubes and destroy air sacs, all contributing factors for COPD.

COPD Overview

Chronic obstructive pulmonary disease (COPD) is a primary, third leading cause of morbidity and mortality globally. COPD is the third leading cause of hospital readmissions in the United States. Chronic obstructive pulmonary disease (COPD) is a group of progressive lung diseases. COPD can cause serious long-term disability and early death. Deaths resulting from COPD in women are higher than in men. The most common of these diseases are emphysema and chronic bronchitis. Most COPD patients have both of these conditions. Emphysema slowly destroys air sacs in the lungs, which interferes with outward air flow. Emphysema causes shortness of breath, In patients with emphysema, the air sacs in the lungs (alveoli) are damaged. Over time, the inner walls of the air sacs weaken and rupture, creating larger air spaces instead of many small ones. This reduces the surface area of the lungs and, in turn, the amount of oxygen that reaches the bloodstream. Chronic bronchitis is inflammation and narrowing of the tubes that carry air to the lungs (bronchial tubes), which allows mucus to build up and leads to a persistent cough.

It’s estimated that about 30 million people in the United States have COPD. As many as half are unaware that they have it. Untreated, COPD can lead to a faster progression of disease, heart problems, and worsening respiratory infections.

Signs and Symptoms of COPD

Chronic obstructive pulmonary disease (COPD) makes it harder for patients to breathe. Symptoms may be mild at first, beginning with intermittent coughing and shortness of breath. As it progresses, symptoms can become more constant to where it can become increasingly difficult to breathe.

COPD patients experience wheezing and tightness in the chest or have excess sputum production. Some patients with COPD have acute exacerbations, which are flare-ups of severe symptoms.

Signs and Symptoms of COPD

Many patients don’t recognize the symptoms of COPD until later stages of the disease. Sometimes patients think they are short of breath or less able to go about their normal activities because they are “just getting older.” Shortness of breath can be an important symptom of lung disease. Following are some of the common signs and symptoms of COPD:

Causes of COPD

Exact cause of COPD is unknown, following are the causes that contribute to COPD:

  • Smoking: Both current smoking and smoking in the past and exposure to second hand smoke is the main cause of COPD in men and women in the United States.
  • However, as many as 1 out of 4 Americans with COPD never smoked. Long-term exposure at home or work to air pollution, including secondhand smoke, chemical fumes and industrial dusts may cause COPD.
  • Respiratory infections may play a role in developing COPD.
  • A rare, inherited disorder called alpha-1-antitrypsin deficiency (AATD)

 

Bay Biosciences is a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens and human bio-fluid collections from cancer (tumor) tissue, cancer serum, cancer plasma cancer PBMC and human tissue samples from most other therapeutic areas and diseases.

Bay Biosciences maintains and manages it’s own bio-repository, human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and from normal healthy donors available in all formats and types. Our biobank procures and stores fully consented, deidentified and institutional review boards (IRB) approved human tissue samples and matched controls.

All our human human tissue collections, human specimens and human bio-fluids are provided with detailed samples associated patient’s clinical data. This critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers and genetic information. Patient’s data is extremely valuable for researchers and is used to help identify new effective treatments (drug discovery & development) in oncology, other therapeutic areas and diseases. This clinical information is critical to demonstrate their impact, monitor the safety of medicines, testing & diagnostics, and generate new knowledge about the causes of disease and illness. 

Bay Biosciences banks wide variety of human tissue samples and biological samples including cryogenically preserved -80°C, fresh, fresh frozen tissue samples, tumor tissue samples, FFPE’s, tissue slides, with matching human bio-fluids, whole blood and blood derived products such as serum, plasma and PBMC’s.

Bay Biosciences is a global leader in collecting and providing human tissue samples according to the researchers specified requirements and customized, tailor made collection protocols. Please contact us anytime to discuss your special research projects and customized human tissue sample requirements.

Bay Biosciences provides human tissue samples (human specimens) from diseased and normal healthy donors; including peripheral whole-blood, amniotic fluid, bronchoalveolar lavage fluid (BAL), sputum, pleural effusion, cerebrospinal fluid (CSF), serum (sera), plasma, peripheral blood mononuclear cells (PBMC’s), saliva, Buffy coat, urine, stool samples, aqueous humor, vitreous humor, kidney stones, renal calculi, nephrolithiasis, urolithiasis and other bodily fluids from most diseases including cancer. We can also procure most human bio-specimens and can do special collections and requests of human samples that are difficult to find. All our human tissue samples are procured through IRB approved clinical protocols and procedures. 

In addition to the standard processing protocols Bay Biosciences can also provide human plasma, serum, PBMC bio-fluid samples using custom processing protocols, you can buy donor specific sample collections in higher volumes and specified sample aliquoting from us. Bay Biosciences also provides human samples from normal healthy donors, volunteers, for controls and clinical research, contact us Now.

 

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