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Excessive Sleepiness Overview

There are various reasons a person may experience excessive sleepiness also known as hypersomnia. These include poor sleep quality and conditions like sleep apnea.

Also, it is natural for people to feel sleepy from time to time, particularly after a long day. Furthermore, excessive sleepiness can be disruptive and make it difficult for a person to go about their normal daily activities.

Because some of the more common causes of excessive sleepiness include not sleeping long enough and having poor quality sleep.

As in some cases, excessive sleepiness may be due to a sleep disorder or another underlying health condition.

Causes of Excessive Sleepiness

However, excessive sleepiness can be difficult to quantify, as it may mean different things to different people.

Although, in general it is a feeling of fatigue or sleepiness that lasts throughout the day or for many days.

Also, excessive sleepiness is a relatively common issue. A 2019 study in Nature Communications notes that 10–20% of people deal with excessive sleepiness to some degree.

There are several possible causes of excessive sleepiness, each of which has different treatments.

Sleep Deprivation

Sleep deprivation occurs when a person does not get enough sleep. The American Academy of Sleep Medicine (AASM) note that adults need between 7 and 8 hours of sleep each night to feel alert and well-rested the following day.

However, according to the AASM, about 20% of adults fail to get enough sleep.

A person who does not get enough sleep during the night is likely to experience excessive sleepiness the next day. People who regularly fail to get enough sleep may feel constantly tired.

Some common causes of sleep deprivation include:

  • An underlying medical condition
  • Excessive or inconsistent work hours
  • Personal obligations

Underlying medical causes require their own specific treatments. In most other cases, simple lifestyle changes can usually improve the duration and quality of a person’s sleep.

Insomnia

Insomnia is a sleep condition in which people have difficulty sleeping. People who have insomnia tend to feel excessively sleepy but are unable to fall or stay asleep.

People may experience insomnia in different ways. Some common symptoms include:

  • Waking continually throughout the night
  • Being unable to get to sleep
  • Waking very early in the morning and being unable to fall back to sleep

Insomnia can be difficult to diagnose. The Centers for Disease Control and Prevention (CDC) note that doctors generally only diagnose insomnia by ruling out other potential sleep disorders.

Treatment

Treatment for insomnia may involve a combination of therapies. Examples include:

  • Antidepressants 
  • Behavioral techniques to promote regular sleep
  • Sedative-hypnotic medications

Obstructive Sleep Apnea

Sleep apnea is a disorder in which a person temporarily stops breathing during sleep. It is a relatively common cause of excessive daytime sleepiness.

There are two types of sleep apnea:

  • Obstructive sleep apnea (OSA): OSA occurs when the soft tissues in the back of the throat collapse, blocking the airflow.
  • Central sleep apnea (CSA): CSA occurs when the brain fails to signal to the respiratory muscles to breathe.

Some people experience mixed sleep apnea, which is a combination of OSA and CSA.

Episodes of sleep apnea may occur dozens or even hundreds of times in a single night. As a result, they can greatly disturb a person’s sleep cycle.

Symptoms

Common symptoms of sleep apnea include very loud snoring and gasping for air throughout the night.

During an episode of sleep apnea, a person’s body becomes temporarily starved of oxygen. This lack of oxygen may lead to other issues, such as an irregular heartbeat. Over time, this can lead to serious chronic conditions, such as high blood pressure and heart disease.

Sleep apnea commonly occurs when a person is overweight. When this is the case, weight loss will be the first recommended treatment.

Treatment

Two common treatments for sleep apnea include:

  • Positive airway pressure devices: These devices consist of a machine that attaches to a mask, which the person wears over their face. The machine supplies pressurized air into a person’s throat while they sleep. The air prevents the throat from collapsing.
  • Oral appliances: These are similar to a mouthguard or orthodontic appliance. The devices hold the lower jaw forward slightly during sleep. This positioning prevents the soft tissues in the back of the throat from collapsing and blocking the airways.

Restless Legs Syndrome

Restless legs syndrome (RLS) refers to an uncontrollable urge to move the legs when they are at rest. The condition usually also causes uncomfortable sensations in the legs.

Also, RLS may occur during both wakefulness and sleep. People who experience RLS when awake may have difficulty getting to sleep.

If RLS happens during sleep, it may cause a person’s legs to spasm or jerk repeatedly throughout the night. While this may not be enough to wake the person, it can prevent them from reaching the stages of deep, restful sleep. As a result, the person may feel sluggish and tired the following day.

Some scientists believe that RLS is due to abnormalities in the neurotransmitter dopamine, which plays a role in controlling muscle movements.

Treatment

Certain lifestyle changes may be beneficial for people with milder cases of RLS. These include:

  • Adopting good sleeping habits
  • Exercising regularly
  • Quitting smoking

However, people with more severe cases of RLS may need medication to regulate the levels of dopamine and iron in the body.

Narcolepsy

Narcolepsy is a neurological condition that causes a person to fall asleep suddenly and at inappropriate times.

Although, people with narcolepsy usually experience extreme and persistent sleepiness throughout the day. Most people with this condition will also have one or more of the following symptoms:

Treatment

Treatment usually involves stimulant medications, which help the person stay awake. Antidepressant medications may help control hallucinations and episodes of sleep paralysis.

Moreover, doctors may also recommend that people take a few good naps throughout the day, as this can improve narcolepsy symptoms.

Depression

Depression may contribute to sleep issues, including excessive daytime sleepiness, as well as oversleeping, or sleep that is not restful. Likewise, sleep issues may contribute to symptoms of depression.

Also, general fatigue and daytime tiredness are common among people with depression. Other symptoms of depression include:

  • Feelings of sadness
  • Difficulty concentrating
  • Feelings of hopelessness or despair
  • Difficulty remembering details
  • Feelings of anxiety

Treatment

Treatment for depression may involve drug therapy, psychotherapy, or a combination of the two.

However, several different types of antidepressant medication are available. A person can talk to their doctor about which medication would be most appropriate for them.

For example, common psychotherapies for depression include cognitive behavioral therapy (CBT) and interpersonal therapy. According to the Anxiety and Depression Association of America, these therapies appear to be particularly effective in treating depression.

Certain Medications

In some cases, daytime sleepiness may be a side effect of a particular medication, such as:

  • Antihistamines
  • Anxiety medications
  • Antipsychotics
  • High blood pressure medications
  • Antidepressants

It is important to discuss the side effects of any medication with a doctor. If side effects such as sleepiness are too difficult to deal with, the doctor may recommend a change in medication or dosage.

Symptoms of Excessive Sleepiness

Excessive sleepiness is not a disorder in itself but a symptom of insufficient sleep or an underlying health condition.

People who experience excessive sleepiness may notice the following:

  • Fatigue
  • Mental fog
  • Inability to focus
  • Grogginess
  • Sluggishness

Additional Symptoms

Also, excessive sleepiness may also cause:

  • Difficulty waking up or getting out of bed in the morning
  • Feeling sluggish and unmotivated throughout the day
  • Difficulty concentrating
  • irritation
  • Difficulty remembering events throughout the day
  • Lapses in attention
  • Napping frequently throughout the day
  • Poor performance in work or school activities
  • Falling asleep at inappropriate times, such as while driving or during meals
  • Loss of appetite

However, a person may experience additional symptoms if their excessive sleepiness is the result of an underlying health condition.


Diagnosis of Excessive Sleepiness

Correctly diagnosing the underlying cause of excessive sleepiness is important for establishing the best treatment.

Furthermore, during the diagnostic procedure, a doctor may ask questions about a person’s lifestyle habits and any medications that they are taking. The doctor may also ask questions relating to mental health.

In some cases, a doctor may order the following diagnostic tests:

  • A sleep study called a polysomnography: This test records a person’s brain waves, oxygen levels, and body movements during sleep to assess their sleep cycle.
  • Electroencephalogram: This noninvasive test records electrical activity in the brain.


Treatment of Excessive Sleepiness

The specific treatment for excessive sleepiness will depend entirely on the cause.

Most healthcare professionals will not want to prescribe highly addictive drugs to assist with sleep, and people who receive a prescription for sleep medications should not take them every day.

However, some general lifestyle changes may help people get a better night’s sleep. These include:

  • Creating a relaxing sleep environment
  • Eating a healthful, balanced diet
  • Keeping a consistent sleep schedule
  • Limiting caffeine and alcohol intake
  • Exercising regularly
  • Taking a warm bath before bedtime

Summary

Excessive sleepiness is normal after a night of poor or insufficient sleep. However, persistent sleepiness could be a symptom of a sleep disorder or some other underlying health condition.

Anyone who regularly experiences excessive sleepiness should visit their doctor for a diagnosis. Treating the underlying cause can improve sleep quality, and it may reduce the risk of other complications.

Many treatment plans incorporate simple lifestyle changes that can help improve sleep quality.

Biospecimens

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Samples available include cancer (tumor) tissue, cancer serum, cancer plasma, cancer, peripheral blood mononuclear cells (PBMC). and human tissue samples from most other therapeutic areas and diseases.

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This critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers, and genetic information.

Patient’s data is extremely valuable for researchers and is used to help identify new effective treatments (drug discovery & development) in oncology, and other therapeutic areas and diseases.

Bay Biosciences banks wide variety of human tissue samples and biological samples, including cryogenically preserved at – 80°C.

For example fresh frozen tissue samplestumor tissue samples, formalin-fixed paraffin-embedded (FFPE), tissue slides, with matching human bio-fluids, whole blood and blood-derived products such as serumplasma and PBMC.

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Please contact us anytime to discuss your special research projects and customized human tissue sample requirements.

Types of Biospecimens

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In addition to the standard processing protocols, Bay Biosciences can also provide human plasmaserum, and PBMC bio-fluid samples using custom processing protocols; you buy donor-specific collections in higher volumes and specified sample aliquots from us.

Bay Biosciences also provides human samples from normal healthy donors; volunteers, for controls and clinical research, contact us Now.

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