Bay Biosciences provides cryogenically frozen (-80) fresh frozen, high quality, clinical  serum (sera), plasma and peripheral blood mononuclear cells (PBMC) biofluid samples from unique chronic hypersensitivity pneumonitis (CHP) patients.

A valued pharmaceutical customer is provided with detailed clinical data and pathology annotations, drug information, smoking history, and other clinical information associated with the serum (sera), plasma, and PBMC bio-fluid samples of Chronic Hypersensitivity Pneumonitis (CHP) patients for research, development, and discovery.

 

Chronic Hypersensitivity Pneumonitis Overview

Hypersensitivity pneumonitis (HP), also called extrinsic allergic alveolitis, is a common form of interstitial lung disease (ILD) that results from repeated inhalation exposure to a variety of antigens. However, in chronic HP, a history of acute episodes is often lacking in patients. Consequently, an insidious onset of cough, progressive dyspnea, fatigue, and weight loss occurs.

Moreover, this condition is associated with partial to complete but gradual reversibility. In addition, clubbing, tachypnea, respiratory distress, and inspiratory crackles over lower lung fields are present in over half of the hypersensitivity pneumonitis (HP) patients.

An allergic reaction occurs in the lungs after certain substances are inhaled; consequently, this leads to pneumonitis, also known as hypersensitivity pneumonitis. Furthermore, inflammation in the air sacs in one or both lungs can be caused by this reaction.

If not treated, the lungs can suffer long-term damage. However, pneumonitis can be completely reversed with quick action. 

Symptoms of Chronic Hypersensitivity Pneumonitis

The intensity, frequency, and areas of the body affected by the symptoms of pneumonitis can vary. **In addition**, the following symptoms may be present:

  • Fatigue
  • Coughing or a rattling sound in the lungs
  • Shortness of breath
  • Clubbing of fingers or toes
  • Fever, chills, and headaches
  • Muscle or joint pain
  • Coughing or a rattling sound in the lungs
  • Severe weight loss

Furthermore, if fluid fills the lungs, it can become a deadly complication of pneumonitis if not caught early and treated. Therefore, people should be vigilant for any of these symptoms if they suspect someone may be suffering from pneumonitis.

Moreover, respiratory issues can be caused by certain complications of pneumonitis or severe flares of symptoms in the lungs. Consequently, scarred tissue in the lungs can prevent them from functioning properly.

Additionally, the amount of oxygen reaching the bloodstream may be reduced. If left untreated, pneumonitis can become life-threatening, making it more difficult for the heart to pump blood through the lungs.

Causes of Chronic Hypersensitivity Pneumonitis

When an irritating substance of any kind is introduced to the lungs, pneumonitis tends to occur. Consequently, this introduction leads to the inflammation of tiny air sacs in the lungs, making it difficult to breathe and causing other symptoms.

In most cases, however, the irritants that cause pneumonitis in the first place are never identified.

Moreover, factors such as occupation, location, gender, and age can all contribute to the risk of pneumonitis. For example, individuals who work with harsh chemicals or irritants are, in fact, more likely to develop pneumonitis than others.

Furthermore, pneumonitis is caused by various factors, which can include:

  • Drugs and antibiotics, including some used in chemotherapy or to control the heartbeat
  • Exposure to birds, bird feathers, or excrement
  • Molds and bacteria
  • Radiation treatment, usually when targeting the chest area

Risk Factors for Chronic Hypersensitivity Pneumonitis

Pneumonitis has many risk factors associated with it.

Due to the ease with which it can develop, pneumonitis is often linked to some specific risk factors. These vary but largely come down to the location and living conditions of an individual.

A person who works with birds for a living, or someone who deals with harsh chemicals, can be more at risk than someone who works in an office, for example.

Risk factors include:

  • Age, as it usually affects those between 50-55 years of age
  • Bird-handling
  • Certain cancer treatments
  • Environment and job, such as working around irritants or large public crowds
  • Genetics
  • Hot tubs and humidifiers
  • Lifestyle habits, such as smoking
  • Sex, as the condition may be slightly more common in women than men

Biospecimens

biospecimens

Bay Biosciences is a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens, and human bio-fluid collections.

Human biospecimens are available including cancer (tumor) tissue, cancer serum, cancer plasma, cancer peripheral blood mononuclear cells (PBMC). and human tissue samples from most other therapeutic areas and diseases.

Bay Biosciences maintains and manages its own biorepository, the human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and from normal healthy donors for controls, available in all formats and types.

In fact, our biobank procures and stores fully consented, de-identified and institutional review boards (IRB) approved human tissue samples, human biofluids such as serum samples, plasma samples from various diseases and matched controls.

Also, all our human tissue collections, human biospecimens and human biofluids are provided with detailed, samples associated patient’s clinical data.

In fact, this critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers, and genetic information.

Additionally, researchers find the patient’s data associated with the human biospecimens extremely valuable and use it to help identify new effective treatments (drug discovery & development) in oncology, as well as in other therapeutic areas and diseases.

Bay Biosciences banks wide variety of human tissue samples and human biological samples, including fresh frozen human biospecimens cryogenically preserved at – 80°C.

For example fresh frozen tissue samples, tumor tissue samples, formalin-fixed paraffin-embedded (FFPE), tissue slides, with matching human bio-fluids, whole blood and blood-derived products such as human serum, human plasma and human PBMCs.

Bay Biosciences is a global leader in collecting and providing human tissue samples according to the specified requirements and customized, tailor-made collection protocols.

Please contact us anytime to discuss your special research projects and customized human tissue sample requirements.

Types of Biospecimens

Bay Biosciences provides human tissue samples (human specimens) and human biofluids from diseased and normal healthy donors which includes:

Moreover, we can also procure most human biospecimens and human biofluids, special collections and requests for human samples that are difficult to find. All our human tissue samples and human biofluids are procured through IRB-approved clinical protocols and procedures.

In addition to the standard processing protocols, Bay Biosciences can also provide human biofluids such as  human plasma, human serum, and human PBMCs bio-fluid samples using custom processing protocols; you buy donor-specific collections in higher volumes and specified sample aliquots from us.

Bay Biosciences also provides human biospecimens from normal healthy donors; volunteers, for controls and clinical research, Contact us Now.