Bay Biosciences provides fresh frozen (-80°) serum, plasma, peripheral blood mononuclear cells (PBMC) biofluid samples from unique patients diagnosed with Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) disease. The serum, plasma, peripheral blood mononuclear cells (PBMC) specimens were collected from unique CIDP patients before and after Intravenous Immunoglobulin (IVIG) treatment.
Chronic inflammatory demyelinating polyneuropathy (CIDP) is a neurological disorder a condition that targets patients body’s nerves, CIDP is characterized by progressive weakness and impaired sensory function in the legs and arms. CIDP disorder is sometimes called chronic relapsing polyneuropathy.
Chronic inflammatory demyelinating polyneuropathy, or CIDP, is a rare and progressive autoimmune disease that affects the nerves in the arms and legs. In patients with CIDP, the protective covering of the peripheral nerves called myelin is damaged by body’s own immune system. Myelin sheath is the fatty covering that wraps around and protects nerve fibers of the peripheral nerves. Damage to nerves and their myelin covering means that messages from the brain to various parts of the body get disrupted, and this can cause weakness and gradual loss of sensations and reflexes. Over time, this damage may lead to disability in the arms and legs.
CIDP can occur at any age and in both male and female patients. CIDP is more common in young adults, and more so in men than women. It often presents with symptoms that include tingling or numbness (beginning in the toes and fingers), weakness of the arms and legs, loss of deep tendon reflexes (areflexia), fatigue and abnormal sensations in the body.
There is no definitive test to diagnose CIDP, and it often requires a referral to a specialists to confirm diagnosis. But there are some tests and tools doctors use to help assess patients for the disease. CIDP progresses over time and often takes longer to diagnose. It is treatable but there is also possibility of relapse.
Signs and Symptoms of Chronic inflammatory demyelinating polyneuropathy (CIDP)
CIDP has a variety of signs and symptoms that differ from person to person Following are some of the common signs and symptoms of CIDP:
- Weakness
- Numbness
- Tingling in the legs, arms, fingers and hands
- Fatigue
- Pain
- Balance issues
- Impairment of ability to walk
- Burning sensation in the fingers, hands, toes and feet
- Impaired condition
- Trouble walking, bending over, reaching and squatting
Symptoms usually occur on both sides of the body at the same time. But sometimes only one side is involved. CIDP patients may experience symptoms in the head, arms fingers, hands, legs, toes and feet. CIDP symptoms can be mild, moderate and severe and change in severity over time.
Causes of Chronic inflammatory demyelinating polyneuropathy (CIDP)
Causes of chronic inflammatory demyelinating polyneuropathy (CIDP) are unknown or why people get the disorder. Researchers believe that CIDP is caused by inflammation of nerves and nerve roots. The swelling can destroy the protective covering around nerves, known as myelin. That can hurt nerve fibers and slow the nerves’ ability to send signals. This is what causes the weakness, pain, fatigue and numbness.
Diagnosis of Chronic inflammatory demyelinating polyneuropathy (CIDP)
It can be a challenge to diagnose CIDP because its symptoms resemble those of other nervous system disorders, because of the similarities with symptoms of other disorders. It can take several months to obtain an accurate diagnosis of CIDP. However, there are some tests and tools doctors use to help assess patients. In most cases a diagnosis will come from a neurologist or a neuromuscular specialist whom you will have been referred to by another doctor. If CIDP is caught early enough, it can be treated, depending on your specific case. An accurate CIDP diagnosis is dependent on tests like an EMG, MRI, or nerve conduction test,
Following tests may be performed to diagnose CIDP:
- Physical Exam – Usually a doctor will perform a physical exam to evaluate the symptoms and may also collect blood samples for laboratory testing. The physical exam will evaluate things such as your strength, sensations, reflexes, gait, and coordination.
- Nerve Conduction Study (NCS) – NCS is an important test that measures how well the patients nerves send signals to different parts of the body. During the test, the nerve is stimulated with mild electrical impulses, usually with surface electrode patches attached to the skin.
- Electromyography (EMG) – This procedure measures the health of muscles and the nerves that control them. During a needle EMG, a needle electrode inserted directly into a muscle records the electrical activity in that muscle. The test results help reveal how severe the nerve damage is and how much recovery may be expected.
- Lumbar Puncture/Spinal Tap – In this medical procedure a needle is inserted into the lower part of the spine to obtain a small sample of the liquid surrounding the spinal cord. This procedure tests for conditions affecting the brain, spinal cord, or other parts of the nervous system.
- Magnetic Resonance Imaging (MRI) – MRI scan test uses a powerful magnetic field and radio waves to make pictures of the spinal cord and nerve bundles. An MRI can help in the diagnosis of CIDP by detecting damage to the nerves.
- Nerve Biopsy – This is an optional and rarely performed procedure where a sample of a nerve is taken from the body and looked at under a microscope. A nerve biopsy can be done to either confirm CIDP or rule out other conditions.
Treatment of Chronic inflammatory demyelinating polyneuropathy (CIDP)
Early treatment of CIDP is very important, it can help prevent the nerve damage that can help stop symptoms from becoming severe. Treatment of CIDP may include:
- Corticosteroids: Corticosteroids are medications that bring down inflammation and slow the immune system.
- Intravenous immunoglobulin (IVIG): Intravenous immunoglobulin (IVIG) is the treatment of choice for patients with antibody deficiencies. CIDP patients may be given IVIG injections of concentrated antibodies from healthy donors to slow the body’s immune response.
- Plasma exchange (PE): Plasma exchange (PE) treatment involves receiving a part of blood called plasma through an intravenous (IV) to slow down the immune system.
- Immunotherapy: Immunotherapy drugs interrupt the immune system to help stop it from attacking the myelin.
- Stem cell transplant. In rare cases, the doctor may inject healthy stem cells, either yours or donated by someone else to reset your immune system.
In addition to the above treatments for CIDP, physical therapy and moderate exercise will help the CIDP patients and make them feel more energetic. CIDP symptoms such as pain are manageable sometimes and hard to deal with at other times. Usually pain is treated with over-the-counter painkillers and other prescription medications.
Detailed clinical data and pathology annotations including patient’s corresponding diagnostic test values, INCAT-ODSS score, Creatine Kinase test data are provided to a valued pharmaceutical customer for research and drug discovery.
Bay Biosciences is a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens and human bio-fluid collections from cancer (tumor) tissue, cancer–serum, cancer–plasma cancer-PBMC and human tissue samples from most other therapeutic areas and diseases.
Bay Biosciences maintains and manages it’s own bio-repository, human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and from normal healthy donors available in all formats and types. Our biobank procures and stores fully consented, deidentified and institutional review boards (IRB) approved human tissue samples and matched controls.
All our human human tissue collections, human specimens and human bio-fluids are provided with detailed samples associated patient’s clinical data. This critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers and genetic information. Patient’s data is extremely valuable for researchers and is used to help identify new effective treatments (drug discovery & development) in oncology, other therapeutic areas and diseases. This clinical information is critical to demonstrate their impact, monitor the safety of medicines, testing & diagnostics, and generate new knowledge about the causes of disease and illness.
Bay Biosciences banks wide variety of human tissue samples and biological samples including cryogenically preserved -80°C, fresh, fresh frozen tissue samples, tumor tissue samples, FFPE’s, tissue slides, with matching human bio-fluids, whole blood and blood derived products such as serum, plasma and PBMC’s.
Bay Biosciences is a global leader in collecting and providing human tissue samples according to the researchers specified requirements and customized, tailor made collection protocols. Please contact us anytime to discuss your special research projects and customized human tissue sample requirements.
Bay Biosciences provides human tissue samples (human specimens) from diseased and normal healthy donors; including peripheral whole-blood, amniotic fluid, bronchoalveolar lavage fluid (BAL), sputum, pleural effusion, cerebrospinal fluid (CSF), serum (sera), plasma, peripheral blood mononuclear cells (PBMC’s), saliva, Buffy coat, urine, stool samples, aqueous humor, vitreous humor, kidney stones, renal calculi, nephrolithiasis, urolithiasis and other bodily fluids from most diseases including cancer. We can also procure most human bio-specimens and can do special collections and requests of human samples that are difficult to find. All our human tissue samples are procured through IRB approved clinical protocols and procedures.
In addition to the standard processing protocols Bay Biosciences can also provide human plasma, serum, PBMC bio-fluid samples using custom processing protocols, you can buy donor specific sample collections in higher volumes and specified sample aliquoting from us. Bay Biosciences also provides human samples from normal healthy donors, volunteers, for controls and clinical research, contact us Now.
日本のお客様は、ベイバイオサイエンスジャパンBay Biosciences Japanまたはhttp://baybiosciences-jp.com/contact/までご連絡ください。