Bay Biosciences provides high quality, clinical grade, fresh frozen sera (serum), plasma and peripheral blood mononuclear cells (PBMC) biofluid samples from patients diagnosed with chronic inflammatory demyelinating polyneuropathy (CIDP).

Moreover, the serum, plasma and PBMCs are processed from cerebral lupus patient’s peripheral whole-blood using customized collection and processing protocols.

Furthermore, the bio-fluid samples are collected from CIDP patients and are provided to a valued pharmaceutical customer for research and drug development.

In addition, detailed clinical information associated with CIDP specimens is provided to a valued customer for research, development and drug discovery.

Chronic inflammatory demyelinating polyneuropathy (CIDP) Overview

Chronic inflammatory demyelinating polyneuropathy (CIDP) is a rare type of autoimmune neurological disorder that causes nerve swelling or inflammation. Specifically, this inflammation destroys the protective coating that is wrapped around nerves and fibers. CIDP is also known as Chronic Relapsing Polyneuropathy (CRP) or Chronic Inflammatory Demyelinating Polyradiculoneuropathy because it involves the nerve roots.

In particular, in an autoimmune disease, the body attacks its own tissues. Consequently, in Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), the body attacks the myelin sheaths. Notably, myelin are the fatty coverings on the fibers that insulate and protect the nerves. As a result, CIDP leads to symptoms such as tingling sensations in the feet and hands. As well as loss of muscle strength.

Moreover, chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is a type of acquired immune-mediated inflammatory disorder. Although it is not contagious, it’s chronic, which means that it is a long-term disease. In addition, patients are likely to live with symptoms and complications of the disorder for the remainder of their life.

Furthermore, CIDP, like the other inflammatory disorders that are similar to it, affects the peripheral nervous system. In summary, this includes the nerves outside the brain and spinal cord.

Causes of Chronic inflammatory demyelinating polyneuropathy (CIDP)

Although experts do not know the exact cause of CIDP, they believe, nonetheless, it is an autoimmune disorder where, in particular, the body’s defense systems attack healthy tissues.

In the case of CIDP, these healthy tissues are, specifically, the myelin sheaths that protect the peripheral nerves and enable the nervous system to transmit signals more quickly. Consequently, nerve inflammation may cause, or, conversely, be caused by the myelin damage.

Furthermore, the disorder is rare, occurring in, on average, around 5–7 people per 100,000 in the United States.

Symptoms of Chronic inflammatory demyelinating polyneuropathy (CIDP)

Symptoms associated with CIDP can recur as flares or episodes; moreover, they may be progressive during an episode, or alternatively, they may remain stable. Some of the condition’s potential symptoms include:

  • Clumsiness
  • Dysphagia or difficulty swallowing
  • Double vision
  • Foot drop
  • Numbness in the hands or feet
  • Tingling or pain in the extremities
  • Loss of sensation in the arms or legs
  • Shortness of breath
  • Unexplained fatigue

Furthermore, the condition’s symptoms tend to occur on both sides of the body — for example, in both legs. However, some people may only notice changes in sensory function, such as tingling and numbness, without experiencing changes in their walking or movement. In addition, these symptoms usually develop gradually and progress over days or sometimes weeks.

Treatment of of Chronic inflammatory demyelinating polyneuropathy (CIDP)

Treatment for CIDP involves aiming to reduce the inflammation and demyelination that cause the nerve-related symptoms. In addition, although there is no cure for the condition, medications that help regulate the immune system can help reduce myelin and nerve inflammation. Specifically, the Food and Drug Administration (FDA) has approved two drugs to treat CIDP: Gamunex and Privigen.

Moreover, these drugs decrease the immune system activity that causes nerve-related symptoms. Notably, both are in the IVIg class, meaning that immunoglobulins are injected intravenously over several hours. Consequently, it works by reducing the effect of the antibodies causing the condition.

Furthermore, both Gamunex and Privigen contain antibodies — immunoglobulins — that help prevent other immunoglobulins from damaging myelin and nerves.

Additionally, another effective option to treat CIDP is plasma exchange or plasmapheresis.

Specifically, this procedure involves removing blood from an individual and separating the red blood cells and components, such as antibodies, from the plasma that contributes to CIDP. Then, donor plasma is added to the blood and transfused back into the individual.

New Treatments

Newer treatments with preparations of higher concentrations of immunoglobulins are available. Consequently, this can be given under the skin — subcutaneously.

While these medications can help to reduce inflammation in CIDP, they do not cure it. Nevertheless, another new treatment option is hematopoietic stem cell transplant (HSCT), which can potentially lead to long-term remission.

Medications

In addition, a doctor may also prescribe medications called immunomodulators that are known to suppress the immune system and improve signs and symptoms of CIDP.

These drugs include:

  • Azathioprine
  • Cyclophosphamide
  • Cyclosporine
  • Methotrexate
  • Mycophenolate

Additional Treatments

Furthermore, in addition to the medications that treat inflammation, there are also treatments that can help reduce the uncomfortable sensory symptoms of CIDP. They include:

  • Amitryptiline
  • Carbamazepine
  • Doxetine
  • Gabapentin
  • Pregabalin

Moreover, some people may have trouble breathing; thus, respiratory support may be necessary until they regain the strength of their respiratory muscles.

 

Biospecimens

biospecimens

Bay Biosciences is a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens, and human bio-fluid collections.

Moreover, human biospecimens are available including tumor tissue, serum, plasma and PBMC samples from most other therapeutic areas.

Furthermore, Bay Biosciences maintains and manages its own biorepository, the human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and likewise normal healthy donors for controls. Additionally, available in all formats and types.

In fact, our biobank procures and stores fully consented, de-identified and institutional review boards (IRB) approved human tissue samples, human biofluids such as serum samples, plasma samples from various diseases and matched controls.

Also, all our human tissue collections, human biospecimens and human biofluids are provided with detailed, samples associated patient’s clinical data.

In fact, this critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers, and genetic information.

Additionally, researchers find the patient’s data associated with the human biospecimens extremely valuable and use it to help identify new effective treatments (drug discovery & development) in oncology, as well as in other therapeutic areas and diseases.

Bay Biosciences banks wide variety of human tissue samples and human biological samples, including fresh frozen human biospecimens cryogenically preserved at – 80°C.

For example fresh frozen tissue samples, tumor tissue samples, formalin-fixed paraffin-embedded (FFPE), tissue slides, with matching human bio-fluids, whole blood and blood-derived products such as human serum, human plasma and human PBMCs.

Bay Biosciences is a global leader in collecting and providing human tissue samples according to the specified requirements and customized, tailor-made collection protocols.

Please contact us anytime to discuss your special research projects and customized human tissue sample requirements.

Types of Biospecimens

Bay Biosciences provides human tissue samples (human specimens) and human biofluids from diseased and normal healthy donors which includes:

Moreover, we can also procure most human biospecimens and human biofluids, special collections and requests for human samples that are difficult to find. All our human tissue samples and human biofluids are procured through IRB-approved clinical protocols and procedures.

In addition to the standard processing protocols, Bay Biosciences can also provide human biofluids such as  human plasma, human serum, and human PBMCs bio-fluid samples using custom processing protocols; you buy donor-specific collections in higher volumes and specified sample aliquots from us.

Bay Biosciences also provides human biospecimens from normal healthy donors; volunteers, for controls and clinical research, Contact us Now.